Editors:
Commemorates the 30th anniversary of the discovery in 1971 of the first DNA topoisomerases, i.e topoisomerase I in E. coli
Pioneer Jim Wang at Harvard University, contributed an article: `Reflections on an accidental discovery' of the enzyme
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Table of contents (9 chapters)
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Front Matter
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Back Matter
About this book
In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators, especially Leroy Liu and his collaborators at Johns Hopkins University. Readers will find a series of chapters written by researchers actively engaged in the expanding field of topoisomerase and their inhibitors. The series of chapters cover review articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer drugs in mammals and in the yeast Saccharomyces cerevisiae, which has proved to be a superb model organism for studies of anticancer drugs. This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology.
Editors and Affiliations
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Department of Bioengineering Faculty of Engineering, Soka University, Hachioji, Tokyo, Japan
Toshiwo Andoh
Bibliographic Information
Book Title: DNA Topoisomerases in Cancer Therapy
Book Subtitle: Present and Future
Editors: Toshiwo Andoh
DOI: https://doi.org/10.1007/978-1-4615-0141-1
Publisher: Springer New York, NY
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eBook Packages: Springer Book Archive
Copyright Information: Springer Science+Business Media New York 2003
Hardcover ISBN: 978-0-306-47744-7Published: 30 June 2003
Softcover ISBN: 978-1-4613-4941-9Published: 23 October 2012
eBook ISBN: 978-1-4615-0141-1Published: 06 December 2012
Edition Number: 1
Number of Pages: XII, 202
Topics: Biochemistry, general, Oncology, Medical Biochemistry