Developments in Tryptophan and Serotonin Metabolism

1. Front Matter

   Pages i-xxi

   PDF

2. Musajo memorial award lecture

   1. Musajo memorial award lecture

      • Osamu Hayaishi’

      Pages 1-11

3. Tryptophan Catabolism and Immunobiology

   1. Front Matter

      Pages 13-13

      PDF

   2. Role Of Ido Activation In Anti-Microbial Defense in Human Native Astrocytes

      • Claudia Oberdörfer, Ortwin Adams, Colin R. MacKenzie, J. A. De Corline, Groot Däubener, Walter Däubener

      Pages 15-26

   3. Tryptophan Catabolism and T Cell Responses

      • Andrew L. Mellor, David Munn, Phillip Chandler, Derin Keskin, Theodore Johnson, Brendan Marshall et al.

      Pages 27-35

   4. Quinolinic Acid Up-Regulates Chemokine Production and Chemokine Receptor Expression in Astrocytes

      • Juliana Croitoru-Lamoury, Gilles J. Guillemin, D. Dormont, Bruce J. Brew

      Pages 37-45

   5. Tryptophan Catabolism in Nonobese Diabetic Mice

      • Ursula Grohmann, Francesca Fallarino, Roberta Bianchi, Carmine Vacca, Ciriana Orabona, Maria Laura Belladonna et al.

      Pages 47-54

   6. Macrophage Activating Properties of The Tryptophan Catabolite Picolinic Acid

      • Maria Carla Bosco, Annamaria Rapisarda, Gioia Reffo, Stefano Massazza, Sandra Pastorino, Luigi Varesio

      Pages 55-65

   7. Regulation of Ido-Mediated Bacteriostasis In Macrophages: Role of Antibiotics And Anti-Inflammatory Agents

      • Colin R. MacKenzie, Daniel Worku, Walter Däubener

      Pages 67-76

   8. Tryptophan Degradation During And After Gestation

      • Katharina Schröcksnadel, Bernhard Widner, Gabriele Neurauter, Dietmar Fuchs, Hans Schröcksnadel, Anton Bergant

      Pages 77-83

   9. Increased mRNA Expression of Kynurenine Pathway Enzymes in Human Placentae Exposed To Bacterial Endotoxin

      • Ursula Manuelpillai, Euan M. Wallace, Trisha Nicholls, Gilles Guillemin, David J Phillips, David Walker

      Pages 85-89

   10. Expression of Indoleamine 2,3-Dioxygenase In Carcinoma of Human Endometrium And Uterine Cervix

       • Peter Sedlmayr, Michaela Semlitsch, Osamu Takikawa, Gottfried Dohr, Girmai Gebrut, Eva Karpf et al.

       Pages 91-95

   11. The Mechanism of Interferon-Gamma Induced Anti Toxoplasma Gondh By Indoleamine 2,3-Dioxygenase And/Or Inducible Nitric Oxide Synthase Vary Among Tissues

       • Suwako Fujigaki, Masao Takemura, Hidetsugu Hamakawa, Mitsuru Seishima, Kuniaki Saito

       Pages 97-103

   12. Expression of The Kynurenine Pathway Enzymes in Human Microglia and Macrophages

       • Gilles J. Guillemin, Danielle G. Smith, George A. Smythe, Patricia J. Armati, George J. Brew

       Pages 105-112

   13. Ido (indolamine 2,3-dioxygenase) Expression and Function in the CNS

       • Erik Kwidzinski, Jörg Bunse, Adam D. Kovac, Oliver Ullrich, Frauke Zipps, Robert Nitsch et al.

       Pages 113-118

4. Kynurenines in Neurobiology

   1. Front Matter

      Pages 119-119

      PDF

   2. Neurokynurenines (Neky) as Common Neurochemical Links of Stress and Anxiety

      • Lapin I.P.

      Pages 121-125

   3. Studies on the Neuroprotective Action of Kynurenine Mono-Oxygenase Inhibitors in Post-Ischemic Brain Damage

      • Flavio Moroni, Raffaella Carpenedo, Andrea Cozzi, Elena Meli, Alberto Chiarugi, Domenico E. Pellegrini-Giampietro

      Pages 127-136

   4. 3-Hydroxykynurenine and Quinolinate: Pathogenic Synergism in Early Grade Huntington’s Disease?

      • Paolo Guidetti, Robert Schwarcz

      Pages 137-145

   5. Accumulation of Quinolinic Acid With Neuroinflammation: Does It Mean Excitotoxicity?

      • Tiho P. Obrenovitch, Jutta Urenjak

      Pages 147-154

This volume contains the proceedings of the Tenth International Meeting of the International Study Group for Tryptophan Research (ISTR V), held at the University of Padova, Padova, Italy, from 25-29 June, 2002 under the auspices of the Ministry of Education, University and Research (MIUR) in Roma, the University of Padova, the Italian Chemical Society - Division of Pharmaceutical Chemistry, the Veneto Region and the City of Padova. The meeting was organized to cover the recent developments in the field of tryptophan research. Weare very honoured that so many speakers accepted our invitation to give plenary lectures which, with the other communications, demonstrated the high scientific value of the Meeting. The publications in this volume are subdivided into nine main chapters, and cover all the major aspects in immunology, neurobiology, psychiatry, pathology, clinics, metabolism, enzymology, pharmacology, toxicology, melatonin, exercise and analytical chemistry. The volume includes the contributions of 325 scientists from 24 countries, and the Musajo Memorial Lecture delivered by Prof. Osamu Hayaishi during the Opening Ceremony.

• Alanin
• Amino acid
• Filtration
• Lipid
• Mutant
• Oxidation
• Purine
• Termination
• enzymes
• gene expression
• metabolism

• University of Padova, Padova, Italy

  Graziella Allegri, Carlo V. L. Costa, Eugenio Ragazzi

• University of Hamburg, Hamburg, Germany

  Hans Steinhart

• Istituto G. Gaslini, Genova Quarto, Italy

  Luigi Varesio

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