Oxygen Transport to Tissue XXIV

1. Front Matter

   Pages i-xxi

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2. Methods for Assessing Oxygen in Tissues

   1. Measurements of Oxygen in Tissues: Overview and Perspectives on Methods

      • Harold M. Swartz, Jeff F. Dunn

      Pages 1-12

   2. Quantitative Brain Tissue Oximetry, Phase Spectroscopy and Imaging the Range of Homeostasis in Piglet Brain

      • Britton Chance, Hong Yan Ma, Shoko Nioka

      Pages 13-18

   3. Tumor Oximetry: Comparison of 19F MR EPI and Electrodes

      • Ralph P. Mason, Sandeep Hunjan, Anca Constantinescu, Yulin Song, Dawen Zhao, Eric W. Hahn et al.

      Pages 19-27

   4. Mapping Cerebral Glutamate ¹³C Turnover and Oxygen Consumption by in Vivo NMR

      • Fahmeed Hyder, Peter Brown, Terennce W. Nixon, Kevin L. Behar

      Pages 29-39

   5. Monte-Carlo Simulation of Light Transport for NIRS Measurements in Tumors of Elliptic Geometry

      • Mojca Pavlin, Tomaž Jarm, Damijan Miklavčič

      Pages 41-49

   6. Arterial Pulsations are Present in One Third of the Human Cranial Vascular Volume Penetrated by Near Infrared Light

      • Robert Stingele, Emanuela Keller, Benedicht P. Wagner, Thorsten Steiner, Karoline Stingele, Werner Hacke

      Pages 51-59

   7. Absolute Frequency-Domain Pulse Oximetry of the Brain: Methodology and Measurements

      • Martin Wolf, Maria A. Franceschini, Lelia A. Paunescu, Vlad Toronov, Antonios Michalos, Ursula Wolf et al.

      Pages 61-73

   8. The Influence of a Clear Layer on Near Infrared Spectrophotometry: Comparison of Measurements in a Liquid Neonatal Head Phantom to Infants In Vivo

      • Martin Wolf, Matthias Keel, Vera Dietz, Kurt von Siebenthal, Jan Teller, Hans-Ulrich Bucher et al.

      Pages 75-84

   9. Strategies for Absolute Calibration of Near Infrared Tomographic Tissue Imaging

      • Troy O. McBride, Brian W. Pogue, Ulf L. Österberg, Keith D. Paulsen

      Pages 85-99

   10. Brain Tissue and Sagittal Sinus pO2 Measurements Using the Lifetimes of Oxygen-Quenched Luminescence of a Ruthenium Compound

       • Casmiar I. Nwaigwe, Marcie A. Roche, Oleg Grinberg, Jeff F. Dunn

       Pages 101-111

   11. Preliminary Studies on the Photon Path in Breast Tissue Model by NIR-TRS

       • Arshia L. Honar, Cory Ricks, Kyung A. Kang

       Pages 113-121

   12. EPR Spectroscopy and Imaging of Oxygen: Applications to the Gastrointestinal Tract

       • Jay L. Zweier, Guanglong He, Alexandre Samouilov, Periannan Kuppusamy

       Pages 123-131

3. Protein C Engineering Issues

   1. Effects of Blocking Buffers and Plasma Proteins on the Protein C Biosensor Performance

      • Heath I. Balcer, James O. Spiker, Kyung A. Kang

      Pages 133-141

   2. Protein C Separation from Human Blood Plasma Derivatives Using Low Cost Chromatography

      • Huiping Wu, Duane F. Bruley

      Pages 143-151

4. Oxygen in Tumors

   1. Glutathione Depletion or Radiation Treatment Alters Respiration and Induces Apoptosis in R3230Ac Mammary Carcinoma

      • John E. Biaglow, Intae Lee, Jerry Donahue, Kathy Held, John Mieyal, Mark Dewhirst et al.

      Pages 153-164

   2. Oxygenation and Vascular Perfusion in Spontaneous and Transplanted Tumor Models

      • Bruce M. Fenton, Scott F. Paoni

      Pages 165-176

   3. Effect of Mild Hyperglycemia ± Meta-Iodo-Benzylguanidine on the Radiation Response of R3230 Ac Tumors

      • Intae Lee, Jerry D. Glickson, Mark W. Dewhirst, Dennis B. Leeper, Randy Burd, Harish Poptani et al.

      Pages 177-186

   4. Effect of Onconase ± Tamoxifen on ASPC-1 Human Pancreatic Tumors in Nude Mice

      • Intae Lee, Young H. Lee, Stanislaw M. Mikulski, Kuslima Shogen

      Pages 187-196

   5. Oxygenation in a Human Tumor Xenograft: Manipulation Through Respiratory Challenge and Antibody-Directed Infarction

      • Ralph P. Mason, Anca Constantinescu, Sophia Ran, Philip E. Thorpe

      Pages 197-204

This volume contains refereed manuscripts prepared from presentations made at the 2ih annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT). The meeting was held in Hanover, NH, USA, at Dartmouth Medical School, the 3rd oldest medical school in the USA. ISOTT attempts to produce high quality pUblications on cutting edge topics relating to oxygen in living systerns. The goal is to allow contributors to contribute original data, as with a main-stream journal article, but also to voice individual opinions and ideas in a more relaxed scientific forum. The meeting brought together an international group of scientists who share a common interest in the measurement and role of oxygen in living systems. The organizers of ISOTT99 made a special effort to bring together people from industry, medicine, and basic sciences in order to improve the links in the chain of discovery through to application. As a result, this volume contains publications on a range of subjects. There are contributions from companies on modifiers of oxygen carrying capacity (allosteric modifiers of hemoglobin and infusible oxygen carriers or blood substitutes); technical reports on oxygen measurement devices including advances in near-infrared spectroscopy and imaging, oxygen electrodes, magnetic resonance spectroscopy and imaging, and fluorescence based measurements. There are medically related sections on modifying and measuring tumor oxygenation in order to improve therapy, assessment and interpretation of oxygenation in the central nervous system, and general issues relating oxygen to pathological conditions.

• Peptide
• blood vessel
• endothelium
• enzymes
• erythrocyte
• gene expression
• kidney
• metabolism
• pathophysiology
• pharmacology
• physiology
• skeletal muscle
• spectroscopy
• surgery
• tissue

• Dartmouth Medical School, Hanover, USA

  Jeffrey F. Dunn, Harold M. Swartz

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