Chemoreception

1. Front Matter

   Pages i-xviii

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2. Honoring Pierre Dejours : His Contribution to the Study of the Role of the Arterial Chemoreceptors in the Regulation of Breathing in Humans

   1. Honoring Pierre Dejours : His Contribution to the Study of the Role of the Arterial Chemoreceptors in the Regulation of Breathing in Humans

      • Henry Gautier

      Pages 1-7

3. O2 and CO2 Sensing Mechanisms in the Peripheral Arterial Chemoreceptors: Membrane Properties, Intracellular Metabolic and Genomic Events

   1. 2P Domain K+ Channels: Novel Pharmacological Targets for Volatile General Anesthetics

      • Amanda J. Patel, Eric Honore

      Pages 9-23

   2. Ca2+ responses to hypoxia are mediated by IP3-R on Ca2+ store depletion

      • Sukhamay Lahiri, Arijit Roy, Jinquing Li, Anil Mokashi, Santhosh M. Baby

      Pages 25-32

   3. Functional Identification of Kvα Subunits Contributing to the O2-Sensitive K+ Current in Rabbit Carotid Body Chemoreceptor Cells

      • J. R. López-López, M. T. Pérez-GARCía, G. Sanz-Alfayate, Ana Obeso, Constancio Gonzalez

      Pages 33-39

   4. Carotid Body Chemoreceptor Activity in Mice Deficient in Selected Subunits of NADPH Oxidase

      • L. He, J. Chen, B. Dinger, K. Sanders, K. Sundar, J. Hoidal et al.

      Pages 41-46

   5. Glucose Sensing Cells in the Carotid Body

      • María García-Fernández, Patricia Ortega-Sáenz, Ricardo Pardal, JosÉ LÓpez-Barneo

      Pages 47-53

   6. Effect of Mitochondrial Inhibitors on Type I Cells

      • Christopher N. Wyatt, Keith J. Buckler

      Pages 55-58

   7. Ascorbate in the Carotid Body

      • Aneta Dymecka, Magdalena Marczak, Ahlam Ramadan, Piotr Suchocki, Mieczysław Pokorski

      Pages 59-64

   8. Studies on Glomus Cell Sensitivity to Hypoxia in Carotid Body Slices

      • Patricia Ortega-Sáenz, María García-Fernández, Ricardo Pardal, Eleuterio Alvarez, José LÓpez-Barneo

      Pages 65-73

   9. An Unusual Cytochrome a592 with Low PO2 Affinity correlates with Afferent Discharge in the Carotid Body

      • Christine Huckstorf, Tino Streller, Helmut Acker

      Pages 75-83

   10. A Reevaluation of the Mechanisms Involved in the Secretion of Catecholamine Evoked by 2, 4-Dinitro Phenol from Chemoreceptor Cells of the Rabbit Carotid Body

       • A. Rocher, E. Geijo, A. I. Caceres, Constancio Gonzalez, L. Almaraz

       Pages 85-93

   11. Enhancing Effect of Vasopressin on the Hyperglycemic Response to Carotid Body Chemoreceptor Stimulation

       • Sergio A. Montero, Alexander Yarkov, Mónica Lemus, Herón Mendoza, Victoria Valles, Elena R. De Álvarez-Buylla et al.

       Pages 95-107

   12. Immunohistochemical Study of the Carotid Body During Acute Hypoxia

       • Kazuo Ohtomo, Yoshiaki Hayashida, Kohko Fukuhara, Hideki Nanri, Masaharu Ikeda, Katsuaki Yoshizaki

       Pages 109-116

   13. Effect of HERG-like Potassium Channel Blocker on the Carotid Body Chemoreception

       • Shinobu Osanai, Toru Takahashi, Hitoshi Nakano, Yoshinobu Ohsaki, Kenjiro Kikuchi

       Pages 117-122

   14. The Effect of Methanandamide on Isolated Type I Cells

       • Christopher N. Wyatt, Keith J. Buckler

       Pages 123-127

   15. Doxapram Stimulates Carotid Body with Different Mechanisms from Hypoxic Chemotransduction

       • Toru Takahashi, Shinobu Osanai, Hitoshi Nakano, Yoshinobu Ohsaki, Kenjiro Kikuchi

       Pages 129-134

   16. Neuromuscular Blocking Agents and Carotid Body Oxygen Sensing

       • Malin Jonsson, Sten G. E. Lindahl, Lars I. Eriksson

       Pages 135-140

4. O2 and CO2 Sensing Mechanisms in Airway Chemoreceptors, Pulmonary Artery Smooth Muscle Cells and Other Oxygen-sensing Systems: Membrane Properties, Intracellular Metabolic and Genomic Events

   1. The Pulmonary Interstitium: an Introductory Review

      • Giuseppe Miserocchi

      Pages 141-145

   2. Regulation of K+ Currents by CO in Carotid Body type I Cells and Pulmonary Artery Smooth Muscle Cells

      • Prem Kumar, Eric Dubuis, Christophe Vandier

      Pages 147-154

Since 1959, the International Society of Arterial Chemoreception (ISAC) has organized in a variety of countries fifteen scientific meetings devoted to the mechanisms of peripheral arterial chemoreception and chemoreceptor reflexes. After the meeting held in Philadelphia with Sukhamay Lahiri as president, ISAC membership elected Lyon (CNRS, University Claude Bernard, France) as the site of the xv" ISAC Symposium. The Symposium was effectively held in Lyon from the 18th to the 22nd of November 2002 and Jean-Marc Pequignot was its president. The organizers were Jean-Marc Pequignot and Yvette Dalmaz Lyon (CNRS, University Claude Bernard, France) and the Scientific Committee was formed by John Carroll (University of Arkansas for Medical Sciences, USA), Constancio Gonzalez (University of Valladolid, Spain), Prem Kumar (University of Birmingham, U. K. ), Sukhamay Lahiri (University of Pennsylvania, Philadelphia, USA), Colin Nurse (McMaster University, Hamilton, Ontario, Canada), and Nanduri Prabhakar (Case Western University, Cleveland, Ohio, USA). The Symposium in Lyon intended to follow the path opened in Philadelphia gathering people working at the interface of cellular and molecular biology with researchers in the more classical topics of chemoreception pathways and reflexes. The aim was to join experts with different perspectives. Along these lines, some participants are engaged in the exploration of the intimate mechanisms of oxygen sensing and cellular responses, with their work centered in a great number of preparations covering a broad spectrum from bacteria, to chemoreceptor cells or to central nervous systems neurons.

• Calcium
• NADPH
• RNA
• cells
• neurons
• pathophysiology
• physiology
• smooth muscle
• tissue
• transcription

• CNRS-University Claude Bernard, Lyon, France

  Jean-Marc Pequignot, Yvette Dalmaz

• University of Valladolid, Valladolid, Spain

  Constancio Gonzalez

• McMaster University, Hamilton, Canada

  Colin A. Nurse

• Case Western Reserve University, Cleveland

  Nanduri R. Prabhakar

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