Cellular Lipid Binding Proteins

1. Front Matter

   Pages i-1

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2. Cellular lipid binding proteins as facilitators and regulators of lipid metabolism

   • Jan F. C. Glatz, Joost J. F. P. Luiken, Marc van Bilsen, Ger J. van der Vusse

   Pages 3-7

3. Critical steps in cellular fatty acid uptake and utilization

   • Ger J. van der Vusse, Marc van Bilsen, Jan F. C. Glatz, Danny M. Hasselbaink, Joost J. F. P. Luiken

   Pages 9-15

4. Mechanism of cellular uptake of long-chain fatty acids: Do we need cellular proteins?

   • James A. Hamilton, Wen Guo, Frits Kamp

   Pages 17-23

5. Similar mechanisms of fatty acid transfer from human anal rodent fatty acid-binding proteins to membranes: Liver, intestine, heart muscle, and adipose tissue FABPs

   • Judith Storch, Jacques H. Veerkamp, Kuo-Tung Hsu

   Pages 25-33

6. Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of their ligands

   • Richard A. Weisiger

   Pages 35-43

7. Insights into binding of fatty acids by fatty acid binding proteins

   • Thorsten Hanhoff, Christian Lücke, Friedrich Spener

   Pages 45-54

8. The effect of charge reversal mutations in the α-helical region of liver fatty acid binding protein on the binding of fatty-acyl CoAs, lysophospholipids and bile acids

   • Robert M. Hagan, Joanna K. Davies, David C. Wilton

   Pages 55-60

9. Solution structure of fatty acid-binding protein from human brain

   • Martin Rademacher, Aukje W. Zimmerman, Heinz Rüterjans, Jacques H. Veerkamp, Christian Lücke

   Pages 61-68

10. Evolution of the family of intracellular lipid binding proteins in vertebrates

    • Frank G. Schaap, Ger J. van der Vusse, Jan F. C. Glatz

    Pages 69-77

11. Intracellular lipid binding proteins of the small intestine

    • Luis B. Agellon, Matthew J. Toth, Alan B. R. Thomson

    Pages 79-82

12. Analysis on the phenotype of E-FABP-gene knockout mice

    • Yuji Owada, Ichiro Suzuki, Tetsuo Noda, Hisatake Kondo

    Pages 83-86

13. Sterol carrier protein-2: Not just for cholesterol any more

    • Eric J. Murphy

    Pages 87-93

14. Fatty acid binding protein expression in different human adipose tissue depots in relation to rates of lipolysis and insulin concentration in obese individuals

    • R. M. Fisher, A. Thörne, A. Hamsten, P. Arner

    Pages 95-100

15. Protein acylation in the cardiac muscle like cell line, H9c2

    • Danny M. Hasselbaink, Theo H. M. Roemen, Ger J. van der Vusse

    Pages 101-112

16. Alternative lipid mobilization: The insect shuttle system

    • Dick J. van der Horst, Dennis van Hoof, Wil J. A. van Marrewijk, Kees W. Rodenburg

    Pages 113-119

17. Giant membrane vesicles as a model to study cellular substrate uptake dissected from metabolism

    • D. P. Y. Koonen, W. A. Coumans, Y. Arumugam, A. Bonen, J. F. C. Glatz, J. J. F. P. Luiken

    Pages 121-130

18. Peroxisome proliferator-activated receptors: Lipid binding proteins controling gene expression

    • Marc van Bilsen, Ger J. van der Vusse, Andries J. Gilde, Martijn Lindhout, Karin A. J. M. van der Lee

    Pages 131-138

19. New insights into the fatty acid-binding protein (FABP) family in the small intestine

    • Philippe Besnard, Isabelle Niot, Hélène Poirier, Lionel Clément, André Bernard

    Pages 139-147

20. Regulation of the ileal bile acid-binding protein gene: An approach to determine its physiological function(s)

    • Jean-François Landrier, Jacques Grober, Isabelle Zaghini, Philippe Besnard

    Pages 149-155

It is well established that cellular lipid binding proteins serve central roles in cellular lipid uptake and metabolism. Evidence has been presented that various metabolic diseases, such as hyperlipidemia, atherosclerosis, insulin resistance, and diabetes, are characterized by malfunctioning or deficiencies in cellular lipid binding proteins. For better understanding of the action of lipids as signaling compounds and the role of lipids in intermediary metabolism, it is essential to have detailed knowledge of the interactions between lipids and their cognant binding proteins. In view of this growing interest in lipid-protein interaction, the 4th International Conference on Lipid Binding Proteins was held in Maastricht, The Netherlands, in June 2001. The proceedings of the previous three meetings have been published in Molecular and Cellular Biochemistry. The present focused issue of Molecular and Cellular Biochemistry comprises selected papers based on the lectures and posters presented during the 4th conference, and provides insight into the significance of these proteins for the functioning of the cell.

• DNA
• Lipid
• biochemistry
• gene expression
• metabolism
• proteins

• Department of Physiology Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands

  Jan F. C. Glatz

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