Overview
- Editors:
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Stefan I. McDonough
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Marine Biological Laboratory, Woods Hole, USA
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Table of contents (11 chapters)
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- Evgeni N. Timin, Stanislav Berjukow, Steffen Hering
Pages 1-19
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- Charles J. Cohen, Richard L. Kraus
Pages 73-93
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- Raymond S. Norton, Jonathan B. Baell, James A. Angus
Pages 143-181
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- Erika S. Piedras-RenterÃa, Paul G. Mermelstein, Geoffrey S. Pitt
Pages 237-275
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- Hironao Saegusa, Tsutomu Tanabe
Pages 277-302
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- Yasuo Mori, Yuko Itsukaichi, Motohiro Nishida, Hiroaki Oka
Pages 303-330
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- Aaron M. Beedle, Gerald W. Zamponi
Pages 331-367
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- Diane Lipscombe, Andrew J. Castiglioni
Pages 369-409
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Back Matter
Pages 411-418
About this book
Voltage-gated calcium channels are critical regulators of cytoplasmic levels of calcium, the universal signaling ion. As such, calcium channels trigger a wide range of cellular functions, from muscle contraction to neurotransmitter secretion, and are important players in human disease. Prominent in the nervous, cardiovascular, and endocrine systems, members of the calcium channel family are targets for existing antihypertensive and anticonvulsant drugs. In addition, they are emerging targets for drugs to treat an extraordinarily diverse group of disorders, including pain, cerebral ischemia, cardiac arrhythmia, and migraine. This book reviews the compounds that target individual calcium channel subtypes and the cellular and behavioral functions governed by each different channel. It contains information for basic scientists using calcium channel antagonists as experimental tools, for behavioralists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel-targeted drugs. Several factors make an entire book on calcium channel pharmacology timely.
Editors and Affiliations
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Marine Biological Laboratory, Woods Hole, USA
Stefan I. McDonough
