Proteases in Tissue Remodelling of Lung and Heart

1. Front Matter

   Pages i-xvi

   PDF

2. Human leukocyte elastase and cystic fibrosis

   • André M. Cantin, Amélie Fournier, Richard Leduc

   Pages 1-33

3. Matrix Metalloproteinases in inflammation of the lung

   • Yves St-Pierre, Céline Van Themsche

   Pages 35-56

4. Proteases in interstitial lung diseases

   • Aline Wille, Tobias Welte, Frank Bühling

   Pages 57-73

5. Matrix Metalloproteinase Inhibitors in Cancer Therapy

   • W. Thomas Purcell, Manuel Hidalgo

   Pages 75-118

6. The Role of Proteases in the Pathogenesis of Lung Emphysema

   • Heiko Golpon, Thomas Köhnlein, Tobias Welte

   Pages 119-126

7. Cardiac Remodelling in Pressure Overload Hypertrophy

   • Ute Seeland, Michael Böhm

   Pages 127-137

8. Ischemia / Myocardial Infarction

   • Tomosaburo Takahashi, Richard T. Lee

   Pages 139-155

9. Matrix Metalloproteinases and Myocardial Remodeling in Heart Failure

   • Yun You Li, Arthur M. Feldman

   Pages 157-189

10. Proteases and Arrhythmias

    • Andreas Goette, Christoph Röcken, Karen Nepple, Uwe Lendeckel

    Pages 191-218

11. Impact of Proteases in Tissue Engineering and Regeneration

    • Heike Mertsching, Carmen Puschmann

    Pages 219-228

12. Back Matter

    Pages 229-237

    PDF

Proteases in Tissue Remodelling of Lung and Heart is unique for its comprehensive presentation of protease function in lung and heart under both physiological conditions and major diseases manifesting in these two organs. The individual chapters have been written by leaders in the field who paid much attention to outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Available animal models (of disease, transgenic, or knock-out) are extensively referred to and experimental data obtained thereby are discussed in the context of patient-derived data.

Proteases in Tissue Remodelling of Lung and Heart:
*is devoted to proteases in lung and heart specifically and extensively,
*covers major diseases of the lung and heart,
*extensively introduces individual proteases (or families thereof),
*presents up-to-date patient-derived and experimental data,
*covers most aspects of protease function in disease.

• cancer
• diagnosis
• experiment
• leukocyte
• pathogenesis
• protein
• regeneration
• therapy
• tissue

• Otto-von-Guericke University Magdeburg, Germany

  Uwe Lendeckel

• University of Leeds Leeds, UK

  Nigel M. Hooper

Uwe Lendeckel is a Reader at the Institute of Experimental Internal Medicine at the Otto-von-Guericke University of Magdeburg, Germany. After his study of pharmacology and toxicology he received his Ph.D in biochemistry in 1990 from the Ernst-Moritz-Arndt University of Greifswald. His thesis on the "expression of the pro-opiomelanocortin gene in rat Islets of Langerhans and other tissues" stimulated his interest in the neuro-immunological cross-talk and the regulatory roles of cell surface proteases therein. In 1989 he joined the ectopeptidase research group at the University of Magdeburg and since then continues to study regulation of expression and the function of T cell ectopeptidases in the normal and pathological immune response, with special focus on the membrane alanyl-aminopeptidase. He has published over 40 research papers. Nigel Hooper is Professor of Biochemistry in the School of Biochemistry and Molecular Biology at the University of Leeds, UK. He received his Ph.D in 1984 from the University of Leeds with a thesis on the "Metabolism of Neuropeptides by Cell-surface Peptidases" which stimulated his interest in proteases and paved the way for much of his subsequent research. He currently co-leads the Proteolysis Research Group at Leeds and among other topics, continues to study the structure and function of several cell-surface proteases, with a particular interest in their mode of attachment to the membrane. He has published over 90 research papers, edited 4 books and co-authored the widely acclaimed undergraduate textbook Instant Notes Biochemistry.

Policies and ethics