Angiogenesis in Brain Tumors

1. Front Matter

   Pages i-xiii

   PDF

2. Principles of Angiogenesis in the Central Nervous System

   1. Front Matter

      Pages 1-1

      PDF

   2. Vasculogenesis and Angiogenesis

      • Sybill Patan

      Pages 3-32

   3. Morphogenesis of Embryonic CNS Vessels

      • Haymo Kurz, Johannes Korn, Bodo Christ

      Pages 33-50

   4. Mathematical Modelling of Tumour-induced Angiogenesis: Network Growth and Structure

      • Mark Chaplain, Alexander Anderson

      Pages 51-75

3. Assessment of Angiogenesis in Neuro-Oncology

   1. Front Matter

      Pages 77-77

      PDF

   2. Histologic Measures of Angiogenesis in Human Primary Brain Tumors

      • Rebecca D. Folkerth

      Pages 79-95

   3. Angiogenesis in transgenic models of multistep angiogenesis

      • Ivan Radovanovic, Maria G. D’Angelo, Adriano Aguzzi

      Pages 97-114

   4. Models for Angiogenesis in Gliomas

      • Roland H. Goldbrunner, Martin Bendszus, Jörg-Christian Tonn

      Pages 115-135

   5. Protocol for Isolation of HCEC

      • Roland H. Goldbrunner, Martin Bendszus, Jörg-Christian Tonn

      Pages 137-138

   6. Protocol for MRI Monitoring of Orthotopic Glioma Growth in the Rat Brain

      • Roland H. Goldbrunner, Martin Bendszus, Jörg-Christian Tonn

      Pages 139-140

   7. Methods to Study Angiogenesis in vitro

      • Katrin Lamszus, Oliver Heese, Manfred Westphal

      Pages 141-146

   8. The Rabbit Corneal Pocket Assay for the Study of Angiogenesis

      • Lucia Morbidelli, Marina Ziche

      Pages 147-151

4. Brain Tumor Related Angiogenesis

   1. Front Matter

      Pages 153-153

      PDF

   2. Role of Nitric Oxide in Tumor Angiogenesis

      • Lucia Morbidelli, Sandra Donnini, Marina Ziche

      Pages 155-167

   3. Angiogenesis-related Growth Factors in Brain Tumors

      • Katrin Lamszus, Oliver Heese, Manfred Westphal

      Pages 169-190

   4. Role of VEGF in Developmental Angiogenesis and in Tumor Angiogenesis in the Brain

      • Marcia Regina Machein, Karl Heinz Plate

      Pages 191-218

   5. Hypoxia and Hypoxia Inducible Factors (HIF) as Important Regulators of Tumor Physiology

      • Till Acker, Karl H. Plate

      Pages 219-248

   6. Vascular Microenvironment in Gliomas

      • Peter Vajkoczy, Michael D. Menger

      Pages 249-262

   7. Angiogenesis and Invasion in Gliomas

      • Lorenzo Bello, Carlo Giussani, Giorgio Carrabba, Mauro Pluderi, Francesco Costa, Andreas Bikfalvi

      Pages 263-284

This volume "Angiogenesis in Brain Tumors" is part of the book series "Cancer Treatment and Research" and offers a detailed overview of the biology of angiogenesis in the central nervous system, the role of angiogenesis in brain tumor development and growth, and anti-angiogenic therapeutic applications. Our understanding of the mutual relationship between tumor growth and concomitant neovascularization has provided important insights into the biology of brain tumors and contributed to the development of new treatment strategies. Many of the early experimental findings on angiogenesis were made using brain tumor models. This was largely due to the fact that brain tumors are among the highest vascularized tumors. In addition, until to date all efforts to develop efficient therapies for these highly malignant tumors have met with little if any success . The scientific evidence on the role of angiogenesis in tumor development accumulated until today has already let to the initiation of several clinical trials. Despite the fact that not all expectations have been fulfilled, the results available so far are promising and suggest that anti­ angiogenic therapeutic strategies may be of benefit to our brain tumor patients in the near future. The volume is comprised of four sections . The first section is dedicated to the principles of angiogenesis in the central nervous system and gives an overview on the cellular, physiological and developmental processes of angiogenesis.

• angiogenesis
• brain tumors
• cancer treatment
• clinical trial
• magnetic resonance imaging (MRI)
• metastasis
• tumor
• tumor growth

• Neurosurgery Carl Gustav Carus Hospital, Technical University of Dresden, Dresden, Germany

  Matthias Kirsch

• Neurosurgery Children’s Hospital Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

  Peter McL. Black

Policies and ethics