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New Concepts in Neurotransmitter Regulation

Proceedings of a Symposium on Drug Abuse and Metabolic Regulation of Neurotransmitters held in La Jolla, Californina, in July 1972

  • Conference proceedings
  • © 1973

Overview

Editors:
  1. Arnold J. Mandell

    1. Department of Psychiatry, School of Medicine, University of California at San Diego, La Jolla, USA

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Table of contents (15 papers)

  1. Front Matter

    Pages i-xii
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  3. Neurotransmitter Regulation and Enzyme Activity

    1. Some Characteristics of Brain Tyrosine Hydroxylase

      • Edith G. McGeer, Paul L. McGeer
      Pages 53-68

    2. Tyrosine Hydroxylase: Subcellular Distribution and Molecular and Kinetic Characteristics of the Different Enzyme Forms

      • José M. Musacchio, Charlene A. McQueen, Gale L. Craviso
      Pages 69-88

    3. Norepinephrine Biosynthesis in Relationship to Neural Activation

      • Norman Weiner, Frank C. Bove, Richard Bjur, Gilles Cloutier, Salomon Z. Langer
      Pages 89-113

  4. New Approaches to Neurotransmitter Regulation

    1. Use of Single Unit Recording in Correlating Transmitter Turnover with Impulse Flow in Monoamine Neurons

      • George K. Aghajanian, Benjamin S. Bunney, Michael J. Kuhar
      Pages 115-134

    2. The Role Of 3′,5′-Cyclic Adenosine Monophosphate in the Regulation of Adrenal Medullary Function

      • Ermino Costa, Alessandro Guidotti
      Pages 135-152

    3. The Use of Autoradiographic Techniques for the Identification and Mapping of Transmitter-Specific Neurones in CNS

      • Leslie L. Iversen, Frederick E. Schon
      Pages 153-193

    4. Neuronal Uptake of Neurotransmitters and their Precursors: Studies with “Transmitter” Amino Acids and Choline

      • Solomon H. Snyder, Henry I. Yamamura, Candace B. Pert, William J. Logan, James P. Bennett
      Pages 195-222

  5. Multivariate Considerations in Neurotransmitter Regulation

    1. Central Noradrenergic Receptors: Localization, Function and Molecular Mechanisms

      • Floyd E. Bloom, Barry J. Hoffer, George R. Siggins
      Pages 223-238

    2. Regulation of 5-HT Synthesis in Central Serotoninergic Neurons

      • Jacques Glowinski, Michel Hamon, Francis Héry
      Pages 239-257

    3. Redundant Macromolecular Mechanisms in Central Synaptic Regulation

      • Arnold J. Mandell
      Pages 259-277

  6. Opiate Drug Effects and Neurotransmitter Regulation

    1. Relation of Brain Serotonin to the Inhibition and Enhancement of Morphine Tolerance and Physical Dependence

      • E. Leong Way, Ing K. Ho, Horace H. Lob
      Pages 279-295

    2. Recent Studies on the Binding of Opiate Narcotics to Possible Receptor Sites

      • Avram Goldstein
      Pages 297-309

  7. Back Matter

    Pages 311-316
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Keywords

About this book

Historically, the development of biological science has proceeded from the anatomy to the physiology of particular systems. Knowledge about neurotransmitters in the brain has evolved from the discovery of the compounds per set through the elucidation of their biosynthetic and degradative pathways, and finally to the current focus, the regulation of these processes. Regulation in a biological system implies the capacity to respond to perturbations. The introduction of standard and speci­ fiable disturbances in a biological system followed by examination of the mechanisms involved in response, i.e. that dampen and/or cancel the induced changes, has proved to be a successful way to elucidate regulatory mechanisms. Psychotropic drugs have been most useful to students of regula­ tory mechanisms in that calvarial prisoner, the brain, for they allow prospective manipulation of variables like dosage and time. Those of us interested in the biological substrata of behavior are especially excited that disturbance induced by drugs leaves the organism intact and behaving, and we can observe behavioral correlates. The pharmacological strategy is, of course, not unique to brain scientists. The relationship between psychotropic drugs and our emerging knowledge of neurotransmitter regulation is, for example, akin to the development of anticancer agents in company with the uncovering of many mysteries of molecular biology.

Editors and Affiliations

  • Department of Psychiatry, School of Medicine, University of California at San Diego, La Jolla, USA

    Arnold J. Mandell

Bibliographic Information

  • Book Title: New Concepts in Neurotransmitter Regulation

  • Book Subtitle: Proceedings of a Symposium on Drug Abuse and Metabolic Regulation of Neurotransmitters held in La Jolla, Californina, in July 1972

  • Editors: Arnold J. Mandell

  • DOI: https://doi.org/10.1007/978-1-4613-4574-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1973

  • Softcover ISBN: 978-1-4613-4576-3Published: 09 October 2011

  • eBook ISBN: 978-1-4613-4574-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 316

  • Topics: Neurology

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