Cancer. A Comprehensive Treatise

1. Front Matter

   Pages i-xx

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2. General Concepts

   1. Front Matter

      Pages 1-1

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   2. Cytogenetics

      • Peter C. Nowell

      Pages 3-31

   3. Genetics: Animal Tumors

      • W. E. Heston

      Pages 33-57

   4. Genetic Influences in Human Tumors

      • Alfred G. Knudson Jr.

      Pages 59-74

   5. Hormones as Etiological Agents in Neoplasia

      • Jacob Furth

      Pages 75-120

   6. Immunocompetence and Malignancy

      • Cornelis J. M. Melief, Robert S. Schwartz

      Pages 121-159

   7. Pathogenesis of Plasmacytomas in Mice

      • Michael Potter

      Pages 161-182

3. Chemical Carcinogenesis

   1. Front Matter

      Pages 183-183

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   2. Metabolism of Chemical Carcinogens

      • J. H. Weisburger, G. M. Williams

      Pages 185-234

   3. Chemical Carcinogenesis: Interactions of Carcinogens with Nucleic Acids

      • D. S. R. Sarma, S. Rajalakshmi, Emmanuel Farber

      Pages 235-287

   4. Some Effects of Chemical Carcinogens on Cell Organelles

      • Donald Svoboda, Janardan Reddy

      Pages 289-322

   5. Sequential Aspects of Chemical Carcinogenesis: Skin

      • Isaac Berenblum

      Pages 323-344

   6. Sequential Aspects of Liver Carcinogenesis

      • George Teebor

      Pages 345-351

   7. Neoantigen Expression in Chemical Carcinogenesis

      • Robert W. Baldwin, Michael R. Price

      Pages 353-383

4. Physical Carcinogenesis

   1. Front Matter

      Pages 385-385

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   2. Physical Carcinogenesis: Radiation—History and Sources

      • Arthur C. Upton

      Pages 387-403

   3. Biophysical Aspects of Radiation Carcinogenesis

      • Albrecht M. Kellerer, Harald H. Rossi

      Pages 405-439

   4. Ultraviolet Radiation: Interaction with Biological Molecules

      • Frederick Urbach

      Pages 441-451

   5. Radiation Carcinogenesis

      • John B. Storer

      Pages 453-483

This series of books attempts to present, in a comprehensive manner, the field of oncology divided into three major areas; etiology, biology, and therapy. These books should serve as landmarks in the rapidly expanding experimental and clinical "universe" of this field. To some, they will be introductory; to others, a summary; for all, critical comments on the futuI'e of research. In l'ecognition of the difficulties inherent in attempting to pause and reflect while experimental data emerge with ever-increasing rapidity, the presentations take the form of overviews rather than reviews. Where possible, an historical perspective on observations and experimentation which led to our present understanding is presented, the state of the art in technique and approach is reviewed, and the gaps in knowledge and in technique are indicated. The aim throughout is integration-using the findings from one approach for comparison with others. The tremendous expansion of interest in oncology as a medical-biological discipline stimulated the publication of these volumes. This expansion, well warranted in terms of the impact of oncology on human morbidity, has been characterized by at least three phenomena. First, there has been an enormous increase in money and manpower devoted to the investigation and treatment of malignancy. That the research has become more and more "directed" or program-oriented signals the interest of those beyond the scientific community in the management of the eHort. Second, increasing numbers of students are entering the field of oncology as their major training program.

• aging
• cancer
• cancer research
• carcinogenesis
• cytogenetics
• histopathology
• hormones
• leukemia
• liver
• morbidity
• mutagen
• oncology
• pathology
• tumor
• tumor growth

• New York University School of Medicine, USA

  Frederick F. Becker

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