Hormonal Regulation of Spermatogenesis

1. Front Matter

   Pages i-xi

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2. Steroid Synthesis and Metabolism: in Vitro Studies

   1. Front Matter

      Pages 1-1

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   2. Distribution of Steroids, Steroid Production and Steroid Metabolizing Enzymes in Rat Testis

      • H. J. van der Molen, J. A. Grootegoed, M. J. de Greef-Bijleveld, F. F. G. Rommerts, G. J. van der Vusse

      Pages 3-23

   3. Androgen Metabolism in the Seminiferous Tubule

      • M. A. Rivarola, E. J. Podesta, H. E. Chemes, S. Cigorraga

      Pages 25-35

   4. Androgen Synthesis and Metabolism by Preparations from the Seminiferous Tubule of the Rat Testis

      • Jennifer H. Dorrington, Irving B. Fritz

      Pages 37-52

   5. Gonadotropic Regulation of 5α-Reductase Activity in the Interstitial Cells and Whole Testis Homogenate of the Immature Rat

      • S. N. Nayfeh, J. C. Coffey, N. J. Kotite, F. S. French

      Pages 53-64

   6. Compartmentation of Microsomal Cytochrome P-450 and 17α-Hydroxylase Activity in the Rat Testis

      • J. L. Purvis, R. H. Menard

      Pages 65-84

   7. Synthesis of Estradiol -17β by Sertoli Cells in Culture: Stimulation by FSH and Dibutyryl Cyclic AMP

      • David T. Armstrong, Young S. Moon, Irving B. Fritz, Jennifer H. Dorrington

      Pages 85-96

   8. Comparison of Steroid Metabolism in Testicular Compartments of Human and Rat Testes

      • Anita H. Payne, Robert P. Kelch

      Pages 97-108

   9. Biosynthesis and Metabolism of Testosterone in Isolated Germ Cells of the Rat and the Ram and in the Sertoli Cells of the Rat

      • M. A. Drosdowsky, M. Tence, J. F. Tence, I. Barral

      Pages 109-121

   10. Testicular Enzymes Related to Steroid Metabolism

       • Bun-ichi Tamaoki, Hiroshi Inano, Keiko Suzuki

       Pages 123-132

3. Steroid Synthesis and Metabolism: Perfusion and Superfusion Studies

   1. Front Matter

      Pages 133-133

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   2. Perfusion of the Male Rat Reproductive Tract: A Model for the Study of Androgen Secretion and Action

      • H. W. G. Baker, C. W. Bardin, G. J. Eichner, L. S. Jefferson, R. J. Santen

      Pages 135-144

   3. Some Factors Affecting Testosterone, Dihydrotestosterone, 5α-Andro­stan-3α,17β-Diol and 5α-Androstan-3β,17β-Diol Secretion by in Vitro Perfused Rabbit Testes

      • Larry L. Ewing

      Pages 145-164

   4. Metabolism and Secretion of Androgens by Rat Seminiferous Tubules: Tracer Superfusion Studies

      • P. G. Satyaswaroop, Erlio Gurpide

      Pages 165-179

   5. Local Increase in Concentration of Steroids by Venous-Arterial Transfer in the Pampiniform Plexus

      • Michael J. Free, Stephen A. Tillson

      Pages 181-194

4. Steroid Hormones in the Seminiferous Tubule

   1. Front Matter

      Pages 195-195

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   2. Regulation of Testosterone and Dihydrotestosterone Levels in Rete Testis Fluid. Evidence for Androgen Biosynthesis in Seminiferous Tubules in Vivo

      • A. Bartke, M. E. Harris, J. K. Voglmayr

      Pages 197-212

   3. Concentration of Steroid Hormones and Androgen Binding Protein (ABP) in Rabbit Efferent Duct Fluid

      • R. Guerrero, E. M. Ritzen, K. Purvis, V. Hansson, F. S. French

      Pages 213-221

   4. The Blood — Testis Barrier and Steroids

      • B. P. Setchell, S. J. Main

      Pages 223-233

The conference represented by this book was made possible by support from NICHD and a planning committee headed by Dr. Richard Sherins. Two general areas of research are included: the first encompasses steroid hormone synthesis, metabolism and transport in the testis; and the second relates to hormonal regula­ tion of the seminiferous tubule with special emphasis on the con­ trol of Sertoli cell function. In addition, there are sections on the purification of unique testicular proteins and morpho­ logical studies with particular emphasis on the Sertoli cell. We would like to express our sincere thanks to Dr. Sherins and his staff at NICHD and to all of the people at the University of North Carolina who participated in the Conference arrangements, to Dr. Judson J. Van Wyk, Chief of the Pediatric Endocrinology Division, and Dr. H. Stanley Bennett, Director of the Laboratories for Reproductive Biology. Our very special thanks to Mrs. Carolyn Jaros for her help in handling the local arrangements. Mrs. Martha Byrd and Mrs. Linda Rollins typed the manuscripts. Miss Leslie Wells and Mr. Albert Smith kindly assisted in proof reading, and Dr. Elizabeth Wilson gave much help with the final editing process. To all of these people, we are most grateful.

• endocrinology
• hormone
• metabolism
• protein
• spermatogenesis
• steroid
• testis
• diabetes

• University of Carolina, USA

  Frank S. French

• Rikshospitalet, Oslo, Norway

  Vidar Hansson

• Karolinska Sjukhuset, Stockholm, Sweden

  E. Martin Ritzen

• University of North Carolina, USA

  Shihadeh N. Nayfeh

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