Riboflavin

1. Front Matter

   Pages i-xiii

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2. Physical and Chemical Properties of Flavins; Binding of Flavins to Protein and Conformational Effects; Biosynthesis of Riboflavin

   • William R. Weimar, Allen H. Neims

   Pages 1-47

3. Analysis of Riboflavin and its Derivatives in Biologic Fluids and Tissues

   • Herman Baker, Oscar Frank

   Pages 49-79

4. Chromatographic and Radioisotopic Methods for the Analysis of Riboflavin and the Flavin Coenzymes

   • Arpad G. Fazekas

   Pages 81-98

5. Absorption, Protein Binding, and Elimination of Riboflavin

   • William J. Jusko, Gerhard Levy

   Pages 99-152

6. Metabolism of Riboflavin

   • Donald B. McCormick

   Pages 153-198

7. Nutritional Intake of Riboflavin

   • Sara M. Hunt

   Pages 199-219

8. Riboflavin Deficiency

   • Grace A. Goldsmith

   Pages 221-244

9. Experimental Dietary and Antagonist-Induced Human Riboflavin Deficiency

   • Montague Lane, Frank E. Smith, Clarence P. Alfrey Jr.

   Pages 245-277

10. Riboflavin Deficiency and Congenital Malformations

    • Josef Warkany

    Pages 279-302

11. Biological Activities of Analogs of Riboflavin

    • John P. Lambooy

    Pages 303-367

12. Riboflavin and Cancer

    • Richard S. Rivlin

    Pages 369-391

13. Hormonal Regulation of Riboflavin Metabolism

    • Richard S. Rivlin

    Pages 393-426

14. Back Matter

    Pages 427-433

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This volume represents an interdisciplinary approach to an understanding of the chemistry, physiology, and medical significance of the vitamin riboflavin. Information has been reviewed on the physiological role of the vitamin, the metabolic effects of riboflavin deficiency in animals and man, and the regulation of riboflavin metabolism. In each chapter early background material has been included, but the major emphasis has been on the many recent advances that have been made. The early chapters of the book are concerned with the physical and chemical properties of riboflavin and its coenzyme derivatives and the nature of the interactions between flavoprotein apoenzymes and their coenzymes. The various methods currently available for measuring f1avins in biological tissues, particularly in man, have been described in detail, together with newer procedures that appear to have certain advantages over existing techniques. Chapters dealing with the absorption, excretion, and metabolism of riboflavin provide basic data on the processes involved in vitamin uptake and in metabolic transformations.

• Absorption
• Riboflavin
• Vitamin
• chemistry
• physiology

• Department of Medicine and Institute of Human Nutrition, College of Physicians and Surgeons of Columbia University, New York, USA

  Richard S. Rivlin

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