Handbook of Psychopharmacology

1. Front Matter

   Pages i-xv

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2. Methods for Studying Unconditioned and Conditioned Behavior

   1. Front Matter

      Pages 1-1

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   2. The Contribution of Ethological Techniques to the Study of Drug Effects

      • J. H. Mackintosh, M. R. A. Chance, A. P. Silverman

      Pages 3-35

   3. A Critique of the Methods Available for the Measurement of Spontaneous Motor Activity

      • T. W. Robbins

      Pages 37-82

   4. The Study of Sequences of Motor Behavior

      • Stata Norton

      Pages 83-105

   5. Schedules of Reinforcement

      • P. B. Dews, Jo DeWeese

      Pages 107-150

   6. Control of Behavior by Noxious Stimuli

      • W. H. Morse, J. W. McKearney, R. T. Kelleher

      Pages 151-180

   7. Theories of Reinforcement, Drive, and Motivation

      • Peter M. Milner

      Pages 181-200

   8. New Considerations in the Neuropsychology of Motivated Behaviors

      • John F. Marshall, Philip Teitelbaum

      Pages 201-229

   9. Animal Behavioral Models of Relevance to Psychiatry

      • R. Kumar

      Pages 231-261

3. Factors that Influence Behavioral Responses to Drugs

   1. Front Matter

      Pages 263-263

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   2. Pharmacogenetics

      • P. L. Broadhurst

      Pages 265-320

   3. Experimental and Clinical Aspects of Drug Dependence

      • R. Kumar, I. P. Stolerman

      Pages 321-367

   4. Social Experience as a Determinant of Normal Behavior and Drug Effect

      • Luigi Valzelli

      Pages 369-392

   5. Developmental Psychopharmacology

      • Paul D. Mabry, Byron A. Campbell

      Pages 393-444

4. Back Matter

   Pages 445-453

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The first six volumes of the Handbook reviewed basic neuropharmacology, drawing on expertise in biochemistry, pharmacology and electrophysiology. The next three volumes focus attention on the functional importance of these basic neuropharmacological mechanisms for normal behavior. In order to study this interface in the intact functioning organism, appropriate methods for describing and quantifying behavior must be developed. The past twenty years have witnessed a revolution in the study of behavior which has taken us away from the often fruitless theoretical arguments to descriptive behaviorism. Technical achievements in the design of apparatus and the recording of behavior played an important role in these developments, and the resultant behavioral methods have been accepted and found useful in studying the effects of drugs. The development of psycho­ pharmacology as a discipline owes as much to these behavioral methods as it does to the basic neuropharmacological techniques pioneered for in vitro studies. In the first section of Volume 7, an effort has been made to provide reviews both of theory and practice in behavioral science. Milner's chapter deals with the concept of motivation in a theoretical framework. By contrast, the chapters by Morse et al. and Dews and DeWeese provide a more descriptive view of the various ways in which aversive stimuli control behavior and the importance of schedules of reinforcement in determining the profile of responding in the animal. The equal importance of observational behav­ ioral methods is well illustrated by Mackintosh et al.

• biochemistry
• motivation
• neuropharmacology
• physiology
• psychopharmacology

• Department of Pharmacology, University of Cambridge, USA

  Leslie L. Iversen

• Department of Psychology, University of Cambridge, USA

  Susan D. Iversen

• Departments of Pharmacology and Psychiatry, The Johns Hopkins University School of Medicine, USA

  Solomon H. Snyder

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