Avian Immunology

1. Front Matter

   Pages i-xv

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2. Lymphoid Development

   1. Front Matter

      Pages 1-1

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   2. Ontogeny

      1. Ontogeny of Myelopoietic Precursor Cells in the Chicken Embryo

         • A. Szenberg

         Pages 3-11

      2. Ontogeny of Hemopoietic Colony-Forming Units in the Chick Embryo Spleen

         • Gordon Keller, Calliopi Havele, Michael Longenecker, Erwin Diener

         Pages 13-28

      3. Differentiation of the Primary Lymphoid Organs in Avian Embryos: Origin and Homing of the Lymphoid Stem Cells

         • N. M. Le Douarin, E. Houssaint, F. Jotereau

         Pages 29-37

      4. Cell Transplantation into Immunodeficient Chicken Embryos Reconstituting Capacity of Different Embryonic Cells

         • Jussi Eskola, Paavo Toivanen

         Pages 39-45

      5. Migration Patterns of Avian Embryonic Bone Marrow Cells and Their Differentiation to Functional T and B Cells

         • W. T. Weber, R. Mausner

         Pages 47-59

   3. B Cell Maturation

      1. Unique Aspects of Immunoglobulin Expression During Early B Cell Differentiation in the Chicken

         • C. E. Grossi, P. M. Lydyard, M. D. Cooper

         Pages 61-72

      2. Analysis of Immunoglobulin Receptors during Antigen-Induced Maturation of B Cells

         • Juraj Ivanyi

         Pages 73-83

3. Lymphocyte Antigens, Receptors, and Factors

   1. Front Matter

      Pages 85-85

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   2. The Production of a Lymphocyte Inhibitory Factor (LyIF) by Bursal and Thymic Lymphocytes

      • D. S. V. Subba Rao, Bruce Glick

      Pages 87-98

   3. Detergent Solubilization of B-Lymphocyte Immunoglobulin

      • John Lifter, Yong Sung Choi

      Pages 99-107

   4. Association of Lymphocyte Alloantigen Genotypes with Levels of Immune Responses

      • D. G. Gilmour, M. A. Palladino, A. R. Scafuri, L. W. Pollard, A. A. Benedict

      Pages 109-120

   5. Rosette Formation in Chicks: With Special Reference to QRBC-Rosettes

      • Koji Sato, Makoto Itoh

      Pages 121-133

4. Regulation of the Immune Responce

   1. Front Matter

      Pages 135-135

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   2. Tolerance

      1. Protein-Induced Neonatal Specific and Non-Specific Immunosuppression

         • Mary Lofy Rodrick, Constantine H. Tempelis

         Pages 137-145

      2. The Role of the Adherent Cell in Antigen-Antibody Complex Induced Immune Unresponsiveness

         • Edward L. Morgan, Hans A. Abplanalp, Constantine H. Tempelis

         Pages 147-154

   3. Suppressor Cells

      1. Infectious Agammaglobulinemia: Suppressor T Cells with Specificity for Individual Immunoglobulin Classes

         • R. Michael Blaese, Andrew V. Muchmore, Irma Koski, Nancy J. Dooley

         Pages 155-159

      2. Further Characterization of the Sensitizing Bursa Cells and of the Target for Suppression in the Transfer of Agammaglobulinemia

         • S. P. Lerman, M. D. Grebenau, M. A. Palladino, G. J. Thorbecke

         Pages 161-173

      3. Regulatory Lymphocytes from Anti-μ Bursectomized Agammaglobulinemic Chickens

         • Gerrie A. Leslie, Vali Kermani-Arab

         Pages 175-185

The ontogeny of lymphoid cells seems the most appropriate place to start. The early events in T and B cell ontogeny are still confusing. There seems to be no agreement on the data and on the semantics of the question of progenitor vs. stem cells. Nevertheless, we are beginning to understand more about progenitor cells which are committed to particular cell lines, and about stem cells in the sense of having almost unlimited capability of giving rise to undifferentiated progeny. An important future development will be to determine the nature of the substances that attract stem cells and which are produced by specialized thymus epithelium, and perhaps by the bursa. The way stem cells recognize these signals is an important question to answer. Not predictable from mammalian models has been the observation that there is a lack of cells called into the bursa even before the signal for entry of stem cells has been shut off. A likely model suggested that after a certain point in development there were no longer any cells capable of migrating into the bursa and becoming B cells. A fascinating possibility is the suggestion that a cell comes into the bursa, is not committed, then can still wander into the thymus. This cell does not appear to have B cell characteris­ tics; that is, immunoglobulin is not expressed on its surface.

• T cell
• antibody
• antigen
• genetics
• histocompatibility
• immune response
• immunity
• immunodeficiency
• immunoglobulin
• immunology
• immunosuppression
• lymphocytes
• resistance
• transplantation
• vaccine

• University of Hawaii at Manoa, USA

  Albert A. Benedict

Policies and ethics