Skip to main content
SpringerLink
Log in

Mass Spectrometry in Drug Metabolism

  • Book
  • © 1977

Overview

Editors:
  1. Alberto Frigerio

    1. “Mario Negri” Institute for Pharmacological Research, Milan, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Emilio L. Ghisalberti

    1. Department of Organic Chemistry, University of Western Australia, Nedlands, Australia

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (32 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Identification of Drugs and Drug Metabolites

    1. A Study on the Metabolism of Feprazone Utilising Mass Spectrometry

      • A. Donetti, L. G. Dring, P. C. Hirom, R. T. Williams
      Pages 1-11

    2. Identification of Some Urinary Metabolites of Iopronic Acid in Human, Rat and Dog

      • D. Pitrè, A. Frigerio, R. Maffei-Facino
      Pages 13-30

    3. Metabolite Identification by GC-MS: Species Differences in the Metabolic Patterns of Isopropylbiphenyl

      • H. R. Sullivan, R. E. McMahon, D. G. Hoffman, S. Ridolfo
      Pages 31-43

    4. Structural Elucidation of an S-Oxidized Metabolite of Trithiozine in Rat and Dog

      • G. Pifferi, P. Ventura, C. Farina, A. Frigerio
      Pages 45-59

    5. Some Metabolites of 9-Hydroxy-19,20-Bis-Nor-Prostanoic Acid

      • R. Caponi, R. Fumagalli, S. Innocenti, P. Martelli, U. Valcavi
      Pages 61-72

    6. Formation of a New Amino Acid as a Metabolic Intermediate of Sodium Dipropylacetate

      • I. Matsumoto, T. Kuhara, M. Yoshino, M. Tetsuo
      Pages 73-80

    7. Identification of the N-Acetyl-β-Aryloxyalanines from Rats Treated with 3-(p-Tolyloxy)-1,2-Propanediol and 3-Phenoxy-1,2-Propanediol

      • T. Kuhara, Y. Inoue, I. Matsumoto
      Pages 81-93

    8. Metabolism in Rat, Dog and Man of Difenpiramide, a New Anti-Inflammatory Drug

      • E. Grassi, G. L. Passetti, A. Trebbi, A. Frigerio
      Pages 95-110

    9. Potential Drugs from Propolis

      • E. L. Ghisalberti, P. R. Jefferies, R. Lanteri
      Pages 111-130

  3. Quantitation of Drugs and Drug Metabolites

    1. Mass Fragmentography (Single and Multiple Ion Monitoring) in Drug Research

      • A. Frigerio, E. L. Ghisalberti
      Pages 131-149

    2. Mass Spectrometric Identification and Quantification of Compounds Involved in the Metabolism of Pyrazofurin

      • J. Roboz, T. Ohnuma
      Pages 151-165

    3. Mass Spectrometry Applied to Metabolism Studies of Org GC 94, a New Anti-Migraine Drug

      • J. Vink, J. J. de Ridder, C. J. Timmer, H. de Nijs
      Pages 167-178

    4. The Identification and Measurement in Urine of Dihydrodigoxin, a Cardioinactive Metabolite of Digoxin

      • H. Greenwood, W. Snedden
      Pages 179-189

    5. Determination of Dimethylnitrosamine in Extracts from Cultures of Trichomonas Vaginalis, Using Gas Chromatography and Mass Spectrometry

      • M. Caramia, G. Poli, M. Landi, L. F. Zerilli
      Pages 191-199

    6. Blood Concentrations of Monoacylcadaverines in Schizophrenia

      • H. Dolezalova, M. Stepita-Klauco, J. Kucera, H. Uchimura, M. Hirano
      Pages 201-213

    7. MHPG, Amitriptyline and Depression: A Collaborative Study

      • E. Sacchetti, E. Smeraldi, E. Allaria, M. Cagnasso, P. A. Biondi
      Pages 215-224

    8. Drugs and Drug Metabolites as Environmental Contaminants: Detection of Chlorophenoxyisobutyrate and Salicylic Acid by GC-MS

      • C. Hignite, D. L. Azarnoff
      Pages 225-235
Back to top

Keywords

About this book

When a dose of drug is administered, three main phases of drug action may be distingushed. In the "pharmaceutical" phase the dosage form disintegrates, the active substance dissolves and becomes available for absorption. The second phase ("pharmaco­ kinetic" phase) includes absorption, distribution, metabolism, and excretion. That fraction of the dose which finally reaches the circulation after absorption will be available for biological action in the third, or "pharmacodynamic" phase when the drug reaches the target tissues and a drug-receptor interaction takes place. The objectives in studies of drug metabolism are: (a) to identify the pathways by which drugs are transformed in the body; (b) to ascertain quantitatively the importance of each pathway and intermediate; (c) to identify and quantify endogenous constituents influenced by the drug or its metabolites which may interfere with common metabolic processes. Since metabolites usually differ from their precursors by only a single chemical group, the resulting metabolic pathways generally consist of a series of closely related compounds. Mass spectrometry is uniquely suited for the analysis of drugs and metabolites for several reasons: only a minimal amount of sample preparation is needed, closely related compounds can be analyzed in a single step, structures can often be deduced directly from the mass spectra without the need for pure reference spectra, and constituents can be quantified with relative ease even when present in fractional nanogram quantity.

Editors and Affiliations

  • “Mario Negri” Institute for Pharmacological Research, Milan, Italy

    Alberto Frigerio

  • Department of Organic Chemistry, University of Western Australia, Nedlands, Australia

    Emilio L. Ghisalberti

Bibliographic Information

  • Book Title: Mass Spectrometry in Drug Metabolism

  • Editors: Alberto Frigerio, Emilio L. Ghisalberti

  • DOI: https://doi.org/10.1007/978-1-4613-4151-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1977

  • Softcover ISBN: 978-1-4613-4153-6Published: 09 October 2011

  • eBook ISBN: 978-1-4613-4151-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 532

  • Topics: Mass Spectrometry, Pharmacology/Toxicology, Life Sciences, general, Medical Biochemistry

Publish with us

Policies and ethics

Back to top

Search

Navigation