Handbook of Psychopharmacology

1. Front Matter

   Pages i-xv

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2. Monoamine Oxidase Inhibitors: Animal Pharmacology

   • Richard F. Squires

   Pages 1-58

3. Monoamine Oxidase, Monoamine-Oxidase-Inhibiting Drugs, and Human Behavior

   • Dennis L. Murphy

   Pages 59-82

4. Tricyclic and Monoamine Oxidase Inhibitor Antidepressants: Structure-Activity Relationships

   • Robert A. Maxwell, Helen L. White

   Pages 83-155

5. Tricyclic Antidepressants: Animal Pharmacology (Biochemical and Metabolic Aspects)

   • Fridolin Sulser

   Pages 157-197

6. Tricyclic and Monoamine-Oxidase-Inhibitor Antidepressants: Clinical Use

   • David J. Kupfer, Thomas P. Detre

   Pages 199-232

7. Lithium Pharmacology and Physiology

   • Nelson Howard Hendler

   Pages 233-273

8. Lithium: Clinical Considerations

   • Baron Shopsin, Samuel Gershon

   Pages 275-325

9. Lithium Prophylaxis and Experimental Rubidium Therapy in Affective Disorders

   • R. R. Fieve, H. L. Meltzer

   Pages 327-369

10. Back Matter

    Pages 371-379

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Underlying the design of the Handbook of Psychopharmacology is a prejudice that the study of drug influences on the mind has advanced to a stage where basic research and clinical application truly mesh. These later volumes of the Handbook are structured according to this conception. In certain volumes, groups of drugs are treated as classes with chapters ranging from basic chemistry to clinical application. Other volumes are assembled around topic areas such as anxiety or affective disorders. Thus, besides chapters on individual drug classes, we have included essays addressing broad areas such as "The Limbic-Hypothalamic-Pituitary-Adrenal System and Human Be­ havior" and "Peptides and the Central Nervous System. " Surveying these diverse contributions, one comes away with a sentiment that, far from being an "applied" science borrowing from fundamental brain chemistry and physiology, psychopharmacology has instead provided basic researchers with the tools and conceptual approaches which now are advancing neurobiology to a central role in modern biology. Especially gratifying is the sense that, while contributing to an understanding of how the brain functions, psychopharmacology is a discipline whose fruits offer genuine help to the mentally ill with promises of escalating benefits in the future. L. L. 1. S. D. 1. S. H. S. VB CONTENTS CHAPTER 1 Monoamine Oxidase Inhibitors: Animal Pharmacology RICHARD F. SQUIRES 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1. 1. Localization. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1. 2. Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1. 3. Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. Inhibition of 5-HT and Catecholamine Synthesis. . . . . . . . 5 3. Inhibition of Spontaneous Firing of 5-HT Neurons. . . . . .

• brain
• chemistry
• drug
• physiology
• psychopharmacology
• research

• Department of Pharmacology, University of Cambridge, UK

  Leslie L. Iversen

• Department of Psychology, University of Cambridge, UK

  Susan D. Iversen

• Departments of Pharmacology and Psychiatry, The Johns Hopkins University School of Medicine, USA

  Solomon H. Snyder

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