Gynecologic Oncology

1. Front Matter

   Pages i-xiv

   PDF

2. Evidence for a Viral Etiology of Squamous Cell Carcinoma of the Cervix

   • Laure Aurelian

   Pages 1-62

3. Tumor Markers in Gynecologic Malignancies

   • John R. van Nagell

   Pages 63-79

4. Hormonal Receptors in Endometrial and Ovarian Neoplasia

   • George S. Richardson, David T. Maclaughlin

   Pages 81-101

5. Germ Cell Tumors of the Ovary: Pathology, Behavior and Treatment

   • Robert J. Kurman, Edmund S. Petrilli

   Pages 103-153

6. Treatment of Advanced Trophoblastic Disease

   • Richard H. J. Begent, Kenneth D. Bagshawe

   Pages 155-186

7. The Immunobiology of Ovarian Carcinoma

   • Robert C. Bast Jr., Robert C. Knapp

   Pages 187-226

8. Lymph Node Metastases from Gynecologic Cancer - Biological Concepts and Therapeutic Implications

   • Arlan F. Fuller Jr.

   Pages 227-261

9. Radiation Therapy of Ovarian Carcinoma

   • Alon J. Dembo, Raymond S. Bush

   Pages 263-298

10. Heavy Particle Radiation Therapy in Gynecological Malignancies

    • Robert D. Hilgers, Steven E. Bush, Francisco Ampuero

    Pages 299-311

11. Growth of Gynecologic Neoplasms in Tissue Culture and as Heterografts

    • Charles E. Welander, John L. Lewis Jr.

    Pages 313-342

12. Clinical Trials in Gynecologic Oncology: Cooperative Group Research

    • George C. Lewis Jr., John Blessing, John R. Kellner

    Pages 343-384

13. Back Matter

    Pages 385-389

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At the turn of the century gynecology had achieved independence from surgery in most medical schools; although gynecologists were surgeons, their interests were turning toward nonsurgical aspects of their specialty. In 1900, merely two years after the Curies' discovery, radium was first used as a treatment for carcinoma of the cervix. In that day cervical cancer claimed more women's lives than any other malignancy and was described by Wil­ liam P. Graves, the second professor of gynecology at Harvard as follows: 'Cancer of the cervix may rightly be termed of all tumors one of the most deadly and most ghastly. It kills by slow torture, causing in later stages months of agonizing pain and producing a discharge of such a foul and nauseating character as to repel proper medical assistance. Nurses declined to care for these cases, while many public hospitals closed their wards to them as patients. ' In late twentieth century parlance the dramatic results of radium therapy would indeed have been called a 'breakthrough'? and radium techniques, later combined with external irradiation, were devel­ oped by gynecologists, no longer just surgeons. Pathology was the basic science of gynecology and gynecologists with a special interest in pathology served as pathologist to the departments of gynecology. As late as 1970 six months of the three-year residency program in obstetrics and gynecology at Harvard were devoted to formal training in pathology.

• carcinoma
• cell
• clinical trial
• gynecology
• metastasis
• pain
• pathology
• surgery
• tumor

• Harvard Medical School, Brigham and Women’s Hospital, Boston, USA

  C. Thomas Griffiths

• Harvard Medical School, Massachusetts General Hospital, Boston, USA

  Arlan F. Fuller

Policies and ethics