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Protein Conformation as an Immunological Signal

  • Book
  • © 1983

Overview

Editors:
  1. Franco Celada

    1. University of Genoa, Genoa, Italy

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    You can also search for this editor in PubMed   Google Scholar

  2. Verne N. Schumaker

    1. University of California, Los Angeles, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Eli E. Sercarz

    1. University of California, Los Angeles, USA

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Table of contents (55 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Influence of Antigen upon Conformation of Antibody

    1. Introduction

      • Franco Celada, Verne N. Schumaker, Eli E. Sercarz
      Pages 1-2

    2. Antibody-Hapten Binding Kinetics, Conformational Transitions and Domains Interactions

      • Israel Pecht
      Pages 3-13

    3. Dynamic Aspects of Signal Transfer in Antibody Molecules

      • Péter Závodszky, Ferenc Kilár, Judit Török, György A. Medgyesi
      Pages 15-29

    4. Could Aggregation of Human Immunoglobulins Bring about Appearance of Novel Antigenic Sites?

      • B. Parodi, V. Dessi, P. Casali, R. Strom, F. Celada
      Pages 31-44

  3. Structure/Function Interrelationships in IgM and IgG

    1. Introduction

      • Franco Celada, Verne N. Schumaker, Eli E. Sercarz
      Pages 45-46

    2. Immunoglobulin M Conformational Change is a Signal for Complement Activation

      • A. Feinstein, N. E. Richardson, B. D. Gorick, N. C. Hughes-Jones
      Pages 47-57

    3. Expression of Fc Effector Function in Homogeneous Murine Anti-Ars IgM

      • Kathryn D. Crossland, Marian E. Koshland
      Pages 59-72

    4. The Localization of Effector Sites on Immunoglobulin G

      • Dennis R. Burton, Raymond A. Dwek, Jirí Novotný
      Pages 73-81

    5. Human Fcγ Fragment: Location of Acidic Residues Involved in Complement Activation

      • R. Bragado, J. A. López de Castro, F. Ortiz, F. Vivanco
      Pages 83-94

  4. Structure of C1, Interactions between Its Subunits and with Other Macromolecules

    1. Introduction

      • Franco Celada, Verne N. Schumaker, Eli E. Sercarz
      Pages 95-96

    2. Ultrastructure of the First Component Of Human Complement

      • Verne N. Schumaker, Pak H. Poon
      Pages 97-114

    3. Binding of Human I125 Fibronectin to C1q and to Human Monoclonal Myeloma IgG Subclasses

      • J. Cseh, L. Jakab, T. Pozsonyi, J. Fehér
      Pages 115-117

    4. Biochemical Specificity of Human Complement Component C1q

      • David H. Bing
      Pages 119-130

    5. Sequence Studies on Human Complement Subcomponent \( {\rm{C\bar 1r}} \)

      • Gérard J. Arlaud, Jean Gagnon, Rodney R. Porter
      Pages 131-135

  5. The Activation of the First Component of Complement

    1. Introduction

      • Franco Celada, Verne N. Schumaker, Eli E. Sercarz
      Pages 137-138

    2. Dissociation of C1 and Concentration Dependence of Its Activation Kinetics

      • Erich Kilchherr, Harald Fuchs, Jurg Tschopp, Jurgen Engel
      Pages 139-140

    3. Fluid Phase Activation of Proenzymic C1r

      • Maurice G. Colomb, Cristian L. Villers, Gérard J. Arlaud
      Pages 141-147

    4. Activation of Mammalian Complement by Chicken C1q

      • Else Marie Nicolaisen
      Pages 149-154

  6. The Importance of Antigen Conformation for Antigenicity and Immunogenicity

    1. Introduction

      • Franco Celada, Verne N. Schumaker, Eli E. Sercarz
      Pages 155-156
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Keywords

About this book

This volume is the collection of papers presented during a four day meeting, the EMBO workshop "Protein Conformation as an Immunological Signal" that took place at Portovenere (La Spezia), Italy, October 1-4, 1981. The motivation that drove us to organize this meeting was the feeling that distinct groups of researchers, active in key areas of modern immunology, sometimes fail to communicate with each other simply because of different traditional affiliations. Yet it is urgent that "molecular" and "cellular" people cooperate more if immunology is to continue the exportation of new concepts to other disciplines. In fact, the deep meaning of molecule-molecule and cell-cell interaction, the generation of signals and their effective transmission which results in elicitation, control or suppression of responses cannot be unraveled without the experts on antibody structure or complement activation sharing their views with the experts on T cell, B cell and macrophage membrane receptors as well as the experts on factors that carry the information released by these cells. Whether the meeting was scientifically fruitful, the reader can judge after having digested these pages. We, the organizers, are not sure whether the optimal amount·of interaction had taken place; especially considering how hard it is to overcome the scientist's catch 22: You have to know something quite well before you get really interested in it. In any event, we are convinced that Portovenere was one of the most successful attempts we have witnessed.

Editors and Affiliations

  • University of Genoa, Genoa, Italy

    Franco Celada

  • University of California, Los Angeles, USA

    Verne N. Schumaker, Eli E. Sercarz

Bibliographic Information

  • Book Title: Protein Conformation as an Immunological Signal

  • Editors: Franco Celada, Verne N. Schumaker, Eli E. Sercarz

  • DOI: https://doi.org/10.1007/978-1-4613-3778-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1983

  • Softcover ISBN: 978-1-4613-3780-5Published: 21 December 2011

  • eBook ISBN: 978-1-4613-3778-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 520

  • Number of Illustrations: 32 b/w illustrations

  • Topics: Biochemistry, general

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