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Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk

  • Book
  • © 1983

Overview

Editors:
  1. Frederick J. Serres

    1. National Institute of Environmental Health Sciences, Research Triangle Park, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. William Sheridan

    1. National Institute of Environmental Health Sciences, Research Triangle Park, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Environmental Science Research (ESRH, volume 28)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-ix
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  2. Introduction

    1. How Much Progress this Time?

      • James V. Neel
      Pages 1-10

  3. Detection of Specific Locus Mutations in Somatic Cells

    1. Human Mutagenicity Monitoring: Studies with 6-Thioguanine Resistant Lymphocytes

      • Richard J. Albertini
      Pages 11-27

    2. Detection of Somatic Mutants of Hemoglobin

      • George Stamatoyannopoulos, Peter E. Nute
      Pages 29-38

    3. Counting of RBC Variants Using Rapid Flow Techniques

      • William L. Bigbee, Elbert W. Branscomb, Ronald H. Jensen
      Pages 39-54

    4. Biochemical Approaches to Monitoring Human Populations for Germinal Mutation Rates: II. Enzyme Deficiency Variants as a Component of the Estimated Genetic Risk

      • Harvey W. Mohrenweiser
      Pages 55-69

  4. Human Monitoring — Detection of Specific Locus Mutations in Germ Cells

    1. Biochemical Approaches to Monitoring Human Populations for Germinal Mutation rates: I. Electrophoresis

      • James V. Neel, Harvey Mohrenweiser, Samir Hanash, Barnett Rosenblum, Stanley Sternberg, Karl-Hans Wurzinger et al.
      Pages 71-93

  6. Utilization of Model Systems in Mice: Part II

    1. Using Inversions to Detect and Study Recessive Lethals and Detrimentals in Mice

      • Thomas H. Roderick
      Pages 135-167

    2. Cataracts — Indicators for Dominant Mutations in Mice and Man

      • Udo H. Ehling
      Pages 169-190

    3. Applications in Genetic Risk Estimation of Data on the Induction of Dominant Skeletal Mutations in Mice

      • Paul B. Selby
      Pages 191-210

    4. Detection of Enzyme Activity Variants in Mice

      • Daniel A. Casciano, Jack B. Bishop, Robert R. Delongchamp, Ritchie J. Feuers
      Pages 211-226

    5. Some Factors Affecting the Mutagenic Response of Mouse Germ Cells to Chemicals

      • Walderico M. Generoso, Katherine T. Cain, April J. Bandy
      Pages 227-239

  8. Future Directions

    1. Some Ideas on Future Test Systems

      • Anthony G. Searle
      Pages 279-288

    2. Problems in Extrapolation of Animal Data to Humans

      • Mary F. Lyon
      Pages 289-305
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Keywords

About this book

The magnitude of the threat to the human genetic material posed by environmental agents has not as yet been fully determined. Never­ theless, the potential hazards of many chemicals have been identi­ fied by studies on lower organisms. However, too little is known regarding the comparability or lack of it between the metabolic pathways available in such organisms and those in man. Although at present there is great public concern for what is considered by some as the excessive use of laboratory animals in toxicological testing, it seems clear that the usage of mammalian systems may be deemed necessary. It has been proposed that cell culture systems might suffice to meet this need, however, such approaches cannot match the complexity of physiological occurances that are present in the intact animal. For studies of genetic effects, some non-invasive human test systems are presently available. These do not, however, meet the re­ quirements for extensive laboratory studies. In order to assess the risks to humans of environmental factors such laboratory investiga­ tions are essential. Therefore, for the forseeable future reliance on experiments using laboratory animals will be necessary. This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations. It covers the most well developed human systems, as well as the most widely used animal tests.

Editors and Affiliations

  • National Institute of Environmental Health Sciences, Research Triangle Park, USA

    Frederick J. Serres, William Sheridan

Bibliographic Information

  • Book Title: Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk

  • Editors: Frederick J. Serres, William Sheridan

  • Series Title: Environmental Science Research

  • DOI: https://doi.org/10.1007/978-1-4613-3739-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1983

  • Hardcover ISBN: 978-0-306-41380-3Due: 01 August 1983

  • Softcover ISBN: 978-1-4613-3741-6Published: 13 October 2011

  • eBook ISBN: 978-1-4613-3739-3Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 341

  • Topics: Physics, general

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