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Chemical Mutagens

Principles and Methods for Their Detection Volume 8

  • Book
  • © 1983

Overview

Editors:
  1. Frederick J. Serres

    1. National Institute of Environmental Health Sciences, Research Triangle Park, USA

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Detection of Effects of Mutagens in Human Populations

    • George R. Hoffmann
    Pages 1-53

  3. The Use of Intact Cellular Activation Systems in Genetic Toxicology Assays

    • Robert Langenbach, Linda Oglesby
    Pages 55-93

  4. The Mouse Spot Test As a Predictor of Heritable Genetic Damage and Other Endpoints

    • Liane B. Russell
    Pages 95-110

  5. The Bone Marrow Micronucleus Assay: Rationale for a Revised Protocol

    • Michael F. Salamone, John A. Heddle
    Pages 111-149

  6. Relationships between the Chemical Structure and Mutagenic Activity of Monocyclic Aromatic Amines

    • Majdi M. Shahin, A. Bugaut, G. Kalopissis
    Pages 151-181

  7. The Measurement of Recessive Lethal Mutations in the Mouse

    • William Sheridan
    Pages 183-199

  8. Chemically Induced Changes in Sperm in Animals and Humans

    • John C. Topham
    Pages 201-234

  9. Mutational Analysis in Cultured Human-Hamster Hybrid Cells

    • C. A. Waldren
    Pages 235-260

  10. Genetic Toxicology of Some Known or Suspected Human Carcinogens

    • Michael D. Waters, Barry E. Howard, Neil E. Garrett, H. Frank Stack, Christine M. Covone-de Serres
    Pages 261-341

  11. Control of Commercial Chemicals: The Sixth Amendment to the Directive on Dangerous Chemical Substances (79/831/EEC) Adopted by the Council of the European Communities

    • Nicola Loprieno
    Pages 343-366

  12. Back Matter

    Pages 367-386
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Keywords

About this book

Volume 8 of Chemical Mutagens covers a wide range of topics in this continuously changing field. This volume includes chapters on the detection of genetic damage in mammalian sperm both at specific loci and over the entire genome. The discussion of in vitro techniques for working with mammalian cells covers not only specific locus assays but also cellular activation systems. Another chapter extensively discusses the need for a revised protocol for the micronucleus assay. Structure­ activity relationships are investigated in a chapter dealing with hair dye constituents. One of the most comprehensive chapters deals with problems associated with the detection of mutagenic effects in defined human populations. Finally, there is a detailed presentation of a comprehensive study tabulating the genetic bioassay data on some known or suspected human carcinogens. In keeping with our policy of publishing important legislation in the area of chemical mutagens, we have also included the Council of the European Communities Directive of 18 September 1979. Frederick J. de Serres Research Triangle Park, North Carolina vii Contents Chapter 1 Detection of Effects of Mutagens in Human Populations George R. Hoffmann 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Monitoring Progeny for Evidence of Germ-Cell Mutations. . . . . 3 2. 1. The Classical Approach: Phenotypic Monitoring . . . . . . . 3 2. 2. Monitoring for Changes in Gene Products . . . . . . . . . . . 7 3. Detection of Gene Mutations in Somatic Cells. . . . . . . . . . . . . 9 3. 1. Drug-Resistant Lymphocytes . . . . . . . . . . . . . . . . . . . . . . 9 3. 2. Hemoglobin Variants . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4. Nongenetic Indicators of Mutagen Exposure . . . . . . . . . . . . . 21 4. 1. Alkylation of Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 4. 2. DNA Damage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Editors and Affiliations

  • National Institute of Environmental Health Sciences, Research Triangle Park, USA

    Frederick J. Serres

Bibliographic Information

  • Book Title: Chemical Mutagens

  • Book Subtitle: Principles and Methods for Their Detection Volume 8

  • Editors: Frederick J. Serres

  • DOI: https://doi.org/10.1007/978-1-4613-3694-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1983

  • Hardcover ISBN: 978-0-306-41336-0Due: 01 September 1983

  • Softcover ISBN: 978-1-4613-3696-9Published: 30 November 2011

  • eBook ISBN: 978-1-4613-3694-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 386

  • Topics: Pharmacology/Toxicology, Chemistry/Food Science, general

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