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Comparative Chemical Mutagenesis

  • Book
  • © 1981

Overview

Editors:
  1. Frederick J. Serres

    1. National Institute of Environmental Health Sciences, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Michael D. Shelby

    1. National Institute of Environmental Health Sciences, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (37 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Introduction

    1. Introduction

      • Frederick J. de Serres
      Pages 1-4

  3. Analysis of Genetic Effects by Test System

    1. Mutagenicity of Selected Chemicals in Escherichia Coli DNA Repair Deficient Assays

      • Herbert S. Rosenkranz
      Pages 5-17

    2. Mutagenicity of Selected Chemicals in the Rec-Assay in Bacillus Subtilis

      • Tsuneo Kada
      Pages 19-26

    3. Mutagenicity of Selected Chemicals in the Salmonella/Microsome Mutagenicity Test

      • Lynne Haroun, Bruce N. Ames
      Pages 27-68

    4. Mutagenicity of Selected Chemicals in Escherichia Coli Test Systems

      • Georges R. Mohn
      Pages 69-107

    5. Mutagenicity of Selected Chemicals in Neurospora Crassa

      • H. E. Brockman, C. Y. Hung, F. J. de Serres, T. M. Ong
      Pages 109-138

    6. Mutagenicity of Selected Chemicals in Yeast: Mutation-Induction at Specific Loci

      • N. Loprieno
      Pages 139-150

    7. Mutagenicity of Selected Chemicals in Yeast: Mitotic Recombination, Gene Conversion, and Nondisjunction

      • F. K. Zimmermann
      Pages 151-174

    8. Mutagenicity of Selected Chemicals in Drosophila

      • E. Vogel, A. Schalet, W. R. Lee, F. Würgler
      Pages 175-255

    9. Mutagenicity of Selected Chemicals in Soybean Test Systems

      • B. K. Vig, Renee Sung
      Pages 257-290

    10. Mutagenicity of Selected Chemicals in Barley Test Systems

      • R. A. Nilan, J. Velemínský
      Pages 291-320

    11. Mutagenicity of Selected Chemicals in Barley: Repair and Recovery

      • J. Velemínský, T. Gichner
      Pages 321-327

    12. Mutagenicity of Ethyl Methanesulfonate, Mitomycin C, and Vinyl Chloride in the Tradescantia Test Systems

      • C. H. Nauman, W. F. Grant
      Pages 329-338

    13. Mutagenicity of Selected Chemicals in Vicia Faba and Allium Cepa Test Systems

      • R. Rieger, A. Michaelis, I. Schubert, B. Kaina, K. Heindorff
      Pages 339-351

    14. Mutagenicity of Selected Chemicals in the Host-Mediated Assay

      • R. Braun, J. Schöneich, M. S. Legator, D. B. McGregor, G. R. Mohn
      Pages 353-392

    15. Mutagenicity of Selected Chemicals in Specific Loci of Cultured Mammalian Cells

      • D. Clive, K. O. Johnson, A. G. Batson, J. F. S. Spector
      Pages 393-431

    16. Mutagenicity of Selected Chemicals in Mammalian in Vitro Cytogenetic Systems

      • J. G. Brewen, A. T. Natarajan, G. Obe
      Pages 433-485

    17. Mutagenicity of Selected Chemicals in the Mammalian Dominant Lethal Assay

      • B. J. Dean, D. Anderson, R. J. Å rám
      Pages 487-538

    18. Mutagenicity of Selected Chemicals in Sister Chromatid Exchange Assays

      • S. Wolff, P. Perry, A. T. Natarajan
      Pages 539-547
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Keywords

About this book

Frederick J. de Serres, Ph. D. Office of the Associate Director for Genetics National Institute of Environmental Health Sciences Research Triangle Park, North Carolina (U. S. A. ) 27709 The Workshop on Comparative Chemical Mutagenesis was orga­ nized to begin the process of problem identification and resolution concerning our needs to evaluate the data on test chemicals arising from assays for mutagenic activity on laboratory organisms. In the past, data on chemical mutagens has been generated and published in the scientific literature on a more or less random basis. Individual chemicals enjoy a brief period of "popularity" that leads to a burst of publications in the same or sometimes related assay systems. The incompleteness of the data base, in many of these cases, makes comparative mutagenesis difficult or impossible. In our attempts to compare the genetic effects of a given chemical over a wide range of assay systems, we are often interested in making quantitative as well as qualitative compari­ sons. To restate the first comparison: is the chemical under ques­ tion a weak, moderate or potent mutagen over a wide range of assay systems--or alternatively, does the level of response vary markedly? To make the second comparison, what is needed is information on the spectrum of genetic alterations produced as well as whether this spectrum is consistent over a wide range of organisms.

Editors and Affiliations

  • National Institute of Environmental Health Sciences, USA

    Frederick J. Serres, Michael D. Shelby

Bibliographic Information

  • Book Title: Comparative Chemical Mutagenesis

  • Editors: Frederick J. Serres, Michael D. Shelby

  • DOI: https://doi.org/10.1007/978-1-4613-3409-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1981

  • Hardcover ISBN: 978-0-306-40930-1Due: 01 March 1982

  • Softcover ISBN: 978-1-4613-3411-8Published: 12 November 2011

  • eBook ISBN: 978-1-4613-3409-5Published: 12 March 2013

  • Edition Number: 1

  • Number of Pages: VIII, 1117

  • Number of Illustrations: 12 b/w illustrations

  • Topics: Evolutionary Biology, Physics, general

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