Nutritional Elements and Clinical Biochemistry

1. Front Matter

   Pages i-xiii

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2. Clinical Correlates in Nutritional Disease

   • Donald E. Hill

   Pages 1-13

3. Clinical Significance of Riboflavin Deficiency

   • Surat Komindr, George E. Nichoalds

   Pages 15-68

4. Role of Vitamin C in Health and Disease

   • Herbert K. Naito

   Pages 69-115

5. Vitamin A and Retinol Binding Protein Alterations in Disease

   • Raymond J. Shamberger

   Pages 117-130

6. Vitamin D — Its Excessive Use in the U.S.A.

   • C. Bruce Taylor, Shi-Kaung Peng

   Pages 131-138

7. The Clinical Implications of Lipid Antioxidant Nutrition

   • Jeffrey Bland

   Pages 139-167

8. Vitamin B12 and Folic Acid: Clinical and Pathophysiological Considerations

   • Ruth C. Steinkamp

   Pages 169-240

9. Trace Metals in Health and Disease

   • Raymond J. Shamberger

   Pages 241-275

10. Role of Specific Nutritional Components on Plasma Lipids, Lipoproteins and Coronary Heart Disease

    • Herbert K. Naito

    Pages 277-316

11. Dietary Management of Hyperlipidemia: The Prudent Polyunsaturated Fat Diet

    • Francine M. Hoerrmann, Donna B. Rosenstock, Herbert K. Naito

    Pages 317-356

12. Effects of Hypoproteinemia on Serum Lipoprotein Composition of Dogs and Rats

    • Lena A. Lewis, Herbert K. Naito, Irvine H. Page, Bruce A. Sebek

    Pages 357-382

13. Dietary Fiber and Disease

    • Jon A. Story

    Pages 383-396

14. Some Manifestations of Malabsorption in Disease

    • James D. Jones, Mary A. Jones

    Pages 397-408

15. Amino Acids in Health and Disease

    • Paul M. Tocci

    Pages 409-419

16. Aminograms in Various Types of Liver Disease

    • Alvin Dubin, Shibban Ganju, Paul B. Szanto, Ann Poulos, Frederick Steigmann

    Pages 421-435

17. The Role of Erythrocyte Amino Acids in Energy Metabolism

    • John E. Sherwin

    Pages 437-450

18. Back Matter

    Pages 451-463

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The important role that the nutritional status exerts in determining the course of life from birth to death in the human being and especially its impact in disease states is only par­ tially appreciated at this time. Nutritional deficiencies are usually considered to be major problems only in under-privileged or developing populations, except for those occurring in specific diseases. This attitude is incorrect as indicated by reports of Bestrian et al (1974, 1976) and Merritt and Suskin (1979) and others who found evidence of nutritional depletion in as much as 50% of the patients in varied groups of hospitalized patients in the United States. Other studies, some of which are included in this book, emphasized the existence of deficiencies of certain specific nutrients. Despite evidence of nutritional deficiencies occurring more frequently than previously appreciated, there is no well established protocol of laboratory studies that the clinical chemist or scientist should provide to help the physician detect lack of essential nutrients before extensive and possibly irreparable damage has occurred to the individual patient. Considerable research data are needed to determine the best biologic material (i.e., erythrocytes, leucocytes, plasma, serum, urine, cerebrospinal fluid, lymph) for analysis to determine accurately at an early stage metabolic deficiencies due to a specific nutritional element. Improved techniques for analysis of key metabolites and nutrients are available in the research labora­ tory and many of them can be adapted to the clinical laboratory.

• Metabolite
• Retinol
• Riboflavin
• Vitamin A
• Vitamin C
• Vitamin D
• Vitamin E
• amino acid
• diabetes
• diabetes mellitus
• genetics
• health
• intestinal microflora
• metabolism
• nutrition

• Departments of Pathology, Biochemistry, and Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA

  Marge A. Brewster

• Metabolic Laboratory, Arkansas Children’s Hospital, Little Rock, USA

  Marge A. Brewster

• Department of Biochemistry, Division of Laboratory Medicine, Department of A therosclerosis and Thrombosis Research, Division of Research, Cleveland Clinic Foundation, Cleveland, USA

  Herbert K. Naito

• Department of Chemistry, Cleveland State University, Cleveland, USA

  Herbert K. Naito

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