Mutation, Cancer, and Malformation

1. Front Matter

   Pages i-xiv

   PDF

2. Genetic Factor in Human Deseases

   1. Environmental Mutagenesis and Disease in Human Populations

      • Arno G. Motulsky

      Pages 1-11

   2. Clinical Genetics of Human Cancer

      • John J. Mulvihill

      Pages 13-34

   3. Chromosome Abnormalities in Cancer Development

      • Masao S. Sasaki

      Pages 35-59

   4. Mutations of Cellular Oncogenes as a Basis for Neoplastic Change

      • Harold E. Varmus

      Pages 61-77

   5. Human Gene Mapping in the Analysis of Oncogenes

      • Fa-Ten Kao

      Pages 79-95

3. Basic Concepts in Mutagenesis and Carcinogenesis

   1. Relationship between Mutagenesis and Carcinogenesis

      • Claes Ramel

      Pages 97-112

   2. Theoretical Basis of Mutagenesis

      • F. E. Würgler

      Pages 113-155

   3. DNA Repair Processes

      • Tomas Lindahl

      Pages 157-166

   4. The Role of DNA Repair in Mutation Induction

      • F. E. Würgler

      Pages 167-196

   5. Use of the Bacillus Subtilis Rec-Assay in Environmental Mutagen Studies

      • Tsuneo Kada, Yoshito Sadaie, Yutaka Sakamoto, Koichi Hirano

      Pages 197-216

   6. Mutagenesis in Yeasts

      • Nicola Loprieno

      Pages 217-232

   7. A Comparison of Genotoxic Activity in Somatic Tissue and in Germ Cells of Drosophila Melanogaster

      • Ekkehart W. Vogel

      Pages 233-255

   8. The P-Factor: A Transposable Element in Drosophila

      • James F. Crow

      Pages 257-273

   9. Silkworm Genetics and Chemical Mutagenesis

      • Y. Tazima

      Pages 275-283

   10. Mutation Induction and Detection in Arabidopsis

       • G. P. Rédei, Gregoria N. Acedo, S. S. Sandhu

       Pages 285-313

   11. Mutagenesis Studies with Cultured Mammalian Cells: Problems and Prospects

       • Ernest H. Y. Chu, I-Chian Li, Jiliang Fu

       Pages 315-346

   12. The Control of Cell Transformation, Mutagenesis, and Differentiation by Chemicals that Initiate or Promote Tumor Formation

       • Eliezer Huberman

       Pages 347-367

   13. Dominant-Lethal Mutations and Heritable Translocations in Mice

       • Walderico M. Generoso

       Pages 369-388

   14. Recessive and Dominant Mutations in Mice

       • U. H. Ehling, J. Favor

       Pages 389-428

During the early 1930s, when I was a graduate student and later a post-doctoral researcher at the National Research Council for the University of Wisconsin at Madison, we had the opportunity to get acquainted with many graduate students from China who were sent to the University for training in modern basic sciences as well as social sciences. The University of Wisconsin continues to graduate a large number of Chinese students. Economic conditions in the 1930s were very precarious for the United States and other parts of the world. Many of us students grew closer together because we were living on similarly tight budgets. As a matter of fact, we subleased a part of our apartment in Madison to some Chinese graduate students. This was a very nice opportunity for us to learn about the scientific and cultural back­ ground of our Chinese friends. Many of them came from the interior of China and had had very little opportunity to become acquainted with people from a western culture. Living with these students was a very pleasant and educational experience which gave us a good pic­ ture of the cultural life and educational system of China at that time--an intimate picture that one normally would not see without travelling in that country.

• DNA
• carcinogenesis
• cell
• fertility
• genetics
• mutagen
• tumor

• University of Michigan Medical School, Ann Harbor, USA

  Ernest H. Y. Chu

• Oak Ridge National Laboratory, Oak Ridge, USA

  Walderico M. Generoso

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