Breast Cancer: Origins, Detection, and Treatment

1. Front Matter

   Pages i-xvii

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2. Growth and Development of Normal and Malignant Mammary Epithelium

   1. The Importance of Epithelial-Stromal Interaction in Mammary Gland Development

      • K. Kratochwil

      Pages 1-12

   2. The Importance of Matrix Interactions and Tissue Topography for the Growth and Differentiation of Mammary Epithelial Cells in Vitro

      • Elisa M. Durban, Janet S. Butel, Jiri Bartek, Joyce Taylor-Papadimitriou

      Pages 13-30

   3. Regulation of Mammary Epithelial Cell Proliferation: An In Vitro Mouse Mammary Epithelial Cell Model System

      • W. Imagawa, G. Bandyopadhyay, M. Spencer, J. Li, S. Nandi

      Pages 31-41

   4. Polypeptide Growth Factors and the Growth of Mammary Epithelial Cells

      • D. Salomon, M. Bano, W. R. Kidwell

      Pages 42-56

   5. Estrogen-Regulated Proteins and Autocrine Control of Cell Growth in Breast Cancer

      • H. Rochefort, F. Capony, G. Cavalie-Barthez, M. Chambon, M. Garcia, O. Massot et al.

      Pages 57-68

3. Biology of Breast Cancer

   1. New Concepts and Approaches in the Analysis of Mammary Preneoplasia and Tumor Progression

      • Francesco Squartini, Ian Hart

      Pages 69-74

   2. Cell Culture Studies: A Perspective on Malignant Progression of Human Breast Cancer

      • H. S. Smith, S. R. Wolman, G. Auer, A. J. Hackett

      Pages 75-89

   3. Workshop on In Vitro Culture Systems

      • R. Hallowes, M. Stampfer

      Pages 90-96

   4. New Approaches to the Pathology of Breast Cancer; Can Immunohistochemistry Add New Information?

      • PH. Hageman, J. L. Peterse

      Pages 97-111

   5. New Developments in Breast Cancer Immunology

      • Diana M. Lopez

      Pages 112-130

   6. Molecular Markers and the Manifestation of Metastasis

      • Zoltan A. Tokes

      Pages 131-155

4. Molecular Basis of Mammary Carcinogenesis

   1. MuMTV Genotype, Protoneoplasia, and Tumor Progression

      • R. D. Cardiff, D. W. Morris, L. J. T. Young, R. Strange

      Pages 156-166

   2. Structural and Biological Properties of the INT-1 Mammary Oncogene

      • R. Nusse, A. Van Ooyen, E. Schuuring, M. Van Lohuizen, F. Rijsewijk

      Pages 167-177

   3. The Role of Specific Regions for Proviral Integration in Mouse Mammary Tumor Virus (MMTV) Induced Tumors

      • H. Diggelmann

      Pages 178-181

   4. Novel Endogenous Retroviral Genomes in Human Genomic DNA

      • J. D. Fetherston, Toby Horn, Renato Mariani-Costantini, Iqbal Ali, Jeffrey Schlom, Robert Callahan

      Pages 182-189

   5. Expression of the Human Harvey RAS Oncogene in Breast Cancer

      • Niki J. Agnantis, Demetrios A. Spandidos

      Pages 190-194

   6. The Search for Oncogenes in Breast Cancer

      • B. Groner, S. Kozma, N. E. Hynes, S. Redmond, R. Jaggi, W. Gunzburg et al.

      Pages 195-204

   7. In Vitro Transformation of Human Breast Epithelial Cells

      • Sidney E. Chang

      Pages 205-226

   8. Of Mice and Women: Genetic Analysis of Breast Cancer In Families

      • Mary Claire King

      Pages 227-236

The control of breast cancer, a leading cause of cancer death in women, will depend ultimately on our understanding of the disease--its origin, and progression which in turn will permit the effective management of its treatment, its detection, and perhaps even its prevention. It is for a better understanding of this spectrum of biological processes crossing back and forth across scientific and clinical disciplines that this volume strives. Several broad topics have been addressed in organizing a large mass of work representing state of the art updates from many of the major breast cancer research groups around the world. The chapters in the first section speak to the factors affecting the growth and development of normal and malignant mammary epithelium. Special emphasis is placed on insights drawn from developmental biology, the cellular interactions that occur in the mammary gland during growth and differentiation; and the study of hormones and growth factors in the regulation of growth and differentiation of normal and malignant breast tissues. In the section on the biology of breast cancer, there is a characterization of relevant model systems for the study of breast cancer and their contribution to our understanding of preneoplasia and progression in mammary cancer. Included as well is the current status of major studies on the immunological aspects of breast cancer and the latest efforts in the development of markers for metastasis in breast cancer.

• breast cancer
• cancer
• cancer research
• hormones
• metastasis
• prevention

• AMC Cancer Research Center, Denver, USA

  Marvin A. Rich, Jean Carol Hager

• Imperial Cancer Research Fund, London, UK

  Joyce Taylor-Papadimitriou

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