Biochemistry and Molecular Genetics of Cancer Metastasis

1. Front Matter

   Pages i-xvii

   PDF

2. Biochemistry and Molecular Biology Aspects

   1. Front Matter

      Pages 1-1

      PDF

   2. Biochemical and Molecular Biology Approaches to Study Cancer Metastases

      • Lance A. Liotta

      Pages 3-10

   3. Use of the Chick Embryo in Studying the Molecular Genetics of Metastasis

      • A. F. Chambers

      Pages 11-23

   4. Integral Membrane Adhesion Glycoproteins: What is their Fate During Metastasis?

      • C. H. Damsky, K. A. Knudsen, A. F. Horwitz, M. J. Wheelock, P. Gruber, C. A. Buck

      Pages 25-42

   5. Peptide Fragments of Fibronectin and Laminin: Role in Cell Adhesion and Inhibition of Experimental Tumor Metastasis

      • L. Furcht, M. Basara, A. Norden-Skubitz, S. Palm, J. McCarthy, D. Sas

      Pages 43-53

   6. Role of ras Oncogenes in Experimental Models of Metastasis

      • U. P. Thorgeirsson, T. Turpeenniemi-Hujanen, M. E. Sobel, J. E. Talmadge, L. A. Liotta

      Pages 55-63

   7. Expression of p21ras Gene Products in Fresh Primary and Metastatic Human Tumor Tissue

      • G. E. Gallick, R. Kurzrock, J. U. Gutterman

      Pages 65-72

   8. A Role for Differentiation Arrest in the Development of Neural Crest Tumors

      • Lee J. Helman, Carol J. Thiele, W. Marston Linehan, Mark A. Israel

      Pages 73-82

   9. Genetic and Epigenetic Regulation of the Metastatic Phenotype: A Basis for Resolving the Controversy Regarding its Selective or Random Nature and Variable Phenotypic Stability

      • R. S. Kerbel, P. Frost, R. G. Liteplo

      Pages 83-99

   10. Cytochemical Cell Typing of Metastatic Tumors According to their Cytoskeletal Proteins

       • R. Moll, W. W. Franke

       Pages 101-114

   11. Biochemistry and Molecular Biology Raw117 Large Cell Lymphoma

       • G. L. Nicolson, V. Rotter, D. Wolf, T. Irimura, C. L. Reading, M. Blick et al.

       Pages 115-127

   12. Karyotypic Progression and Metastasis Formation of Human Tumors

       • Peter C. Nowell, Gloria Balaban

       Pages 129-136

   13. Morphological and Functional Alterations of Occludens, Adherens, and Gap Junctions in Cancer

       • B. U. Pauli, R. S. Weinstein

       Pages 137-150

   14. Pattern of Basement Membrane Degradation by Metastatic Tumor Cell Enzymes

       • K. Tryggvason

       Pages 151-163

3. Immunologic Mechanisms

   1. Front Matter

      Pages 165-165

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   2. Gene Products of the Major Histocompatibility Complex Control the Metastatic Phenotype of Tumor Cells

      • L. Eisenbach, S. Katzav, G. Hammerling, S. Segal, M. Feldman

      Pages 167-184

   3. Generation of Metastatic Cells via Somatic Cell Fusion: A Possible Mechanism for Tumor Progression In-Vivo

      • P. de Baetselier, E. Roos, L. Brys, L. Remels, M. Feldman

      Pages 185-198

   4. The Recognition and Destruction of Metastatic Cells by Tumoricidal Macrophages

      • I. J. Fidler

      Pages 199-212

   5. Biological Response Modifiers for the Therapy of Metastases

      • Ronald B. Herberman, Robert H. Wiltrout, Raoul R. Salup, John R. Ortaldo, Elieser Gorelik

      Pages 213-224

The success rate for treatment of primary neoplasms has improved sig­ nificantly due to improved surgical, radiotherapy, and chemotherapy methods, and by supportive patient care. In contrast, the treatment of cancer metastases, the cause of most cancer deaths, has not been very successful. Approximately 50% or more of patients with primary malignant neoplasms already have established metastases. Consequently, the most important problem in cancer treatment is the destruction or prevention of metastases. Metastases research has obvious clinical importance. Yet it has only been recently that investigators have attempted to study the mechanisms in­ volved in this process. This is in part due to the complexity of metastases formation. A metastatic colony is the result of a complicated series of steps involving mUltiple tumor host interactions. It is expected that multiple biochemical factors and gene products derived both from the host and the tumor cell may be required for the metastasizing tumor cell to invade, survive host defenses, travel in the circulation, arrest and adhere in the target organ, invade out, and grow as a metastatic colony. Some of these factors have recently been identified by investigators who have focused on individual steps in the metastatic process and have employed new technologies in immunology, biochemistry and molecular biology. The purpose of this volume is to capture some of the excitement in the field of metastases based on such new discoveries.

• Colon
• biochemistry
• enzymes
• genes
• genetics
• metastatic disease
• proteins
• regulation
• tissue

• I. Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Budapest, Hungary

  Karoly Lapis

• Laboratory of Pathology National Cancer Institute, National Institutes of Health, Bethesda, USA

  Lance A. Liotta, Alan S. Rabson

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