Overview
- Editors:
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Karoly Lapis
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I. Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Budapest, Hungary
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Lance A. Liotta
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Laboratory of Pathology National Cancer Institute, National Institutes of Health, Bethesda, USA
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Alan S. Rabson
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Laboratory of Pathology National Cancer Institute, National Institutes of Health, Bethesda, USA
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Table of contents (25 papers)
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Front Matter
Pages i-xvii
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Biochemistry and Molecular Biology Aspects
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- C. H. Damsky, K. A. Knudsen, A. F. Horwitz, M. J. Wheelock, P. Gruber, C. A. Buck
Pages 25-42
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- L. Furcht, M. Basara, A. Norden-Skubitz, S. Palm, J. McCarthy, D. Sas
Pages 43-53
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- U. P. Thorgeirsson, T. Turpeenniemi-Hujanen, M. E. Sobel, J. E. Talmadge, L. A. Liotta
Pages 55-63
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- G. E. Gallick, R. Kurzrock, J. U. Gutterman
Pages 65-72
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- Lee J. Helman, Carol J. Thiele, W. Marston Linehan, Mark A. Israel
Pages 73-82
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- R. S. Kerbel, P. Frost, R. G. Liteplo
Pages 83-99
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- G. L. Nicolson, V. Rotter, D. Wolf, T. Irimura, C. L. Reading, M. Blick et al.
Pages 115-127
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- Peter C. Nowell, Gloria Balaban
Pages 129-136
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- B. U. Pauli, R. S. Weinstein
Pages 137-150
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Immunologic Mechanisms
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Front Matter
Pages 165-165
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- L. Eisenbach, S. Katzav, G. Hammerling, S. Segal, M. Feldman
Pages 167-184
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- P. de Baetselier, E. Roos, L. Brys, L. Remels, M. Feldman
Pages 185-198
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- Ronald B. Herberman, Robert H. Wiltrout, Raoul R. Salup, John R. Ortaldo, Elieser Gorelik
Pages 213-224
About this book
The success rate for treatment of primary neoplasms has improved sig nificantly due to improved surgical, radiotherapy, and chemotherapy methods, and by supportive patient care. In contrast, the treatment of cancer metastases, the cause of most cancer deaths, has not been very successful. Approximately 50% or more of patients with primary malignant neoplasms already have established metastases. Consequently, the most important problem in cancer treatment is the destruction or prevention of metastases. Metastases research has obvious clinical importance. Yet it has only been recently that investigators have attempted to study the mechanisms in volved in this process. This is in part due to the complexity of metastases formation. A metastatic colony is the result of a complicated series of steps involving mUltiple tumor host interactions. It is expected that multiple biochemical factors and gene products derived both from the host and the tumor cell may be required for the metastasizing tumor cell to invade, survive host defenses, travel in the circulation, arrest and adhere in the target organ, invade out, and grow as a metastatic colony. Some of these factors have recently been identified by investigators who have focused on individual steps in the metastatic process and have employed new technologies in immunology, biochemistry and molecular biology. The purpose of this volume is to capture some of the excitement in the field of metastases based on such new discoveries.