Biology of Brain Tumour

1. Front Matter

   Pages I-XI

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2. Molecular Neurooncology

   1. Front Matter

      Pages 1-1

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   2. Molecular biology of cancer

      • John Paul

      Pages 3-6

   3. Two-dimensional gel electrophoretic protein patterns in high-grade human astrocytomas

      • Raj K. Narayan, William E. Heydorn, G. Joseph Creed, Paul L. Kornblith, David M. Jacobowitz

      Pages 7-14

   4. Biochemical studies of primary cultures from human astrocytomas: observations on cell growth and regulation of glutamine synthetase

      • Ambrish J. Patel, Mary D. Weir, John L. Darling, David G. T. Thomas, Antony Hunt

      Pages 15-25

   5. Dibutyryl adenosine 3′:5′-cyclic monophosphate (db-cAMP) induced growth inhibition and morphologic changes in human medulloblastoma cell line TE671

      • Fumiaki Sasaki, Sandra L. Schneider, Paul M. Zeltzer

      Pages 27-34

   6. Phenotypic modification of human glioma

      • R. I. Freshney, Margaret C. Frame, P. F. T. Vaughan, D. I. Graham

      Pages 35-41

   7. Chromosomes and chromosomal progression of malignant human gliomas: theoretical and practical implications

      • S. H. Bigner, J. Mark, P. C. Burger, D. E. Bullard, S. C. Schold Jr, M. S. Mahaley Jr et al.

      Pages 43-49

   8. Differential expression of neuron specific enolase and creatine phosphokinase-BB by human medulloblastoma and glioma tumors and neuroectodermal cell lines

      • Paul M. Zeltzer, Sandra L. Schneider, Paul J. Marangos, Mark H. Zweig

      Pages 51-59

   9. Neovascularisation of intracranial tumours

      • R. H. Lye, S. F. Elstow, J. B. Weiss

      Pages 61-66

   10. Red blood cell polyamines in malignant glioma patients. Spermidine and spermine blood levels and tumour evolution

       • J. Ph Moulinoux, V. Quemener, H. Hercouet, F. Darcel, M. Chatel

       Pages 67-74

3. Modem Neuropathology

   1. Front Matter

      Pages 75-75

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   2. Pathological classification of tumours of the central nervous system

      • R. O. Barnard

      Pages 77-79

   3. Modern neuropathological investigative techniques of brain tumours

      • P. L. Lantos

      Pages 81-84

   4. Adenylate cyclase activity and cyclic AMP content in human central nervous system tumors and in cerebrospinal fluid of patients bearing brain tumors

      • Giorgio Racagni, Emilio Iuliano, Giovanni Sangiovanni, Pietro Paoletti

      Pages 85-90

   5. Non-nuclear cytotoxic actions of DNA cross-linking and/or alkylating agents in glioma-derived cell lines

      • B. H. Smith, M. A. Greenwood, C. J. Cummins, J. Ellis, C. Gibson, P. L. Kornblith

      Pages 91-96

   6. Intracerebral transplantation of D-54 MG human glioma line in immunosuppressed rats

      • Carol Adams, Dennis E. Bullard, Sandra H. Bigner, Darell D. Bigner

      Pages 97-105

   7. In vivo characterization of a human neuroectodermal tumor cell line

      • Mohsen Rahman, Herman Yeger, Laurence E. Becker

      Pages 107-114

   8. Carbonic anhydrase C as a marker antigen in the diagnosis of choroid plexus papillomas and other tumours: an immunoperoxidase study.

      • Roy O. Weiler, Philip V. Steart, Isabella E. Moore

      Pages 115-120

   9. Transplacental ENU tumors of the rat: immunohistochemical contribution to the recognition of cell types

      • Maria Teresa Giordana, Davide Schiffer, Alessandro Mauro, Antonio Migheli

      Pages 121-129

This volume contains the proceedings of the Second International Symposium on Biology of Brain Tumour. The first Symposium was held in 1979 at Gardonne Riviera, Italy. This meeting was planned in order to coincide with the lOOth Anniversary of the first reported operation for glioma in London on November 25, 1884. Since the first meeting, the field of neuro-oncology has made remarkable progress in understanding both basic and clinical factors of significance to patients with brain tumor. While the earlier meeting dealt to a large extent with clinically oriented studies, this symposium was more heavily weighted toward the biology of brain tumour and improving our understanding at the physiologic, biochemical, pharmacologic, and cellular level. The meeting was divided according to scientific content into presentations and discussions as well as posters for more leisurely viewing, so as to allow the main themes of the meeting to sequentially develop. The first session dealt extensively with neuro-oncology at the molecular level and included considerable discus­ sion of material related to the babic biochemical milieu in which tumors originate, proliferate, and eventually destroy the brain. Classic neuropathology has been the mainstay of tumor identification and characteriza­ tion, however, the process of classification has become much more complex. The availability of a variety of new tools has allowed investigation into the validity of the more traditional classification systems as well as the development of newer biologically related concepts.

• Carcinom
• Staging
• brachytherapy
• classification
• glioma
• microsurgery
• neuropathology
• radiotherapy
• surgery

• National Institutes of Health, Bethesda, USA

  Michael D. Walker

• Institute of Neurology, University of London, London, England

  David G. T. Thomas

Policies and ethics