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Aneuploidy

Etiology and Mechanisms

  • Book
  • © 1985

Overview

Editors:
  1. Vicki L. Dellarco

    1. U.S. Environment Protection Agency, USA

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  2. Peter E. Voytek

    1. U.S. Environment Protection Agency, USA

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  3. Alexander Hollaender

    1. Council for Research Planning in Biological Sciences, Inc., USA

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  4. B. R. Brinkley

    1. University of Alabama, Birmingham, USA

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  5. Ernest B. Hook

    1. New York State Department of Health, Albany, USA

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  6. Montrose J. Moses

    1. Duke University School of Medicine, Durham, USA

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  7. Frederick J. Serres

    1. National Institute of Environmental Health Sciences, USA

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  8. T. C. Hsu

    1. M. D. Anderson Hospital and Tumor Institute, Houston, USA

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  9. Liane B. Russell

    1. Oak Ridge National Laboratory, Oak Ridge, USA

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  10. Raymond R. Tice

    1. Brookhaven National Laboratory, Upton, USA

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  11. Michael D. Waters

    1. U.S. Environmental Protection Agency Research Triagle Park, USA

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Part of the book series: Basic Life Sciences (BLSC, volume 36)

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Table of contents (37 chapters)

  1. Front Matter

    Pages iii-xiv
    Download chapter PDF

  2. Introduction

    1. Introduction: Assessment of Health Risks

      • Peter E. Voytek
      Pages 1-6

  3. Human Aspects

    2. Etiological Aspects of Human Aneuploidy

      1. Meiotic Investigations of Aneuploidy in the Human
        • M. Hulten, N. Saadallah, B. M. N. Wallace, D. J. Cockburn
        Pages 75-90
      2. Chromosomal Abnormalities in Human Sperm
        • Renee H. Martin
        Pages 91-102
      3. The Origin of Aneuploidy in Humans
        • Terry J. Hassold
        Pages 103-115
      4. Maternal Age, Paternal Age, and Human Chromosome Abnormality: Nature, Magnitude, Etiology, and Mechanisms of Effects
        • Ernest B. Hook
        Pages 117-132
      5. Genetic Factors Influencing Aneuploidy Frequency
        • Dorothy Warburton
        Pages 133-148
      6. Environmental Causes of Aneuploidy: Why So Elusive?
        • Jennie Kline, Zena Stein
        Pages 149-164

    3. Neoplasia

      1. Neoplasia and Cytogenetic Abnormalities
        • H. J. Evans
        Pages 165-178

    4. Roundtable Discussion

      1. Roundtable Discussion: Human Aspects of Aneuploidy
        • Ernest B. Hook
        Pages 179-182

  4. Mechanisms Underlying Chromosome Disjunction/Nondisjunction

    1. Chromosome Movement and Distribution

      1. Mitosis in Eukaryotic Cells: An Overview of Chromosome Distribution
        • R. Bruce Nicklas
        Pages 183-195
      2. Spindle Structure and the Mechanisms of Chromosome Movement
        • J. Richard McIntosh
        Pages 197-229
      3. Characterization of a Tightly Centromere-Linked Gene Essential for Meiosis in the Yeast <u>Saccharomyces</u> <u>Cerevisiae</u>
        • Elaine Yeh, Kerry Bloom
        Pages 231-242
      4. The Kinetochore of Mammalian Chromosomes: Structure and Function in Normal Mitosis and Aneuploidy
        • B. R. Brinkley, A. Tousson, M. M. Valdivia
        Pages 243-267
      5. Microtubule Dynamics and the Mitotic Cycle: A Model
        • M. De Brabander, F. Aerts, J. De Mey, G. Geuens, M. Moeremans, R. Nuydens et al.
        Pages 269-278
      6. Aneuploidy Induction by Mitotic Arrestants in Animal Cell Systems: Possible Mechanisms
        • T. C. Hsu, K. L. Satya-Prakash
        Pages 279-289
      7. A Model for the Mechanism of Aneuploidy Involving Chromosome Displacement
        • Judith Helen Ford
        Pages 291-295
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Keywords

About this book

The "Symposium on Aneuploidy: Etiology and Mechanisms" was held at the Carnegie Institution of Washington Auditorium from March 25-29. 1985. This Symposium developed as a consequence of the concern of the Environmen­ tal Protection Agency with the support of the National Institute of Envi­ ronmental Health Sciences about human exposure to environmental agents that cause aneuploidy. The program was chosen to explore what is currently known about the underlying causes, the origins, and the extent of the prob­ lem of human aneuploidy, and whether exposure to environmental agents is assodated with an increased incidence of aneuploidy in humans. Basic research findings in the area of mitosis and meiosis were presented and related to possible mechanisms of how aneuploidy may be produced spontane­ ously and chemically. A survey of data regarding the chemical induction of aneuploidy in experimental organisms was presented. Outstanding scientists from different fields were invited to cover a broad perspective of aneu­ ploidy from the molecular aspects to the human situation. We hope that the publication of the proceedings will share the enthu­ siasm of the meeting and its scientific content. The topic of aneuploidy has received little attention and it is the purpose of this Volume to establish a scientific basis for assessing health risks posed by environ­ mental exposures to aneuploidy-inducing chemicals. Vicki L. DeJlarco Peter E. Voytek Alexander Hollaender vii ACKNOWLEDGEMENT The Editors of the proceedings of the "Symposium on Aneuploidy" wish to acknowledge the support of Dr. Elizabeth L.

Editors and Affiliations

  • U.S. Environment Protection Agency, USA

    Vicki L. Dellarco, Peter E. Voytek

  • Council for Research Planning in Biological Sciences, Inc., USA

    Alexander Hollaender

  • University of Alabama, Birmingham, USA

    B. R. Brinkley

  • New York State Department of Health, Albany, USA

    Ernest B. Hook

  • Duke University School of Medicine, Durham, USA

    Montrose J. Moses

  • National Institute of Environmental Health Sciences, USA

    Frederick J. Serres

  • M. D. Anderson Hospital and Tumor Institute, Houston, USA

    T. C. Hsu

  • Oak Ridge National Laboratory, Oak Ridge, USA

    Liane B. Russell

  • Brookhaven National Laboratory, Upton, USA

    Raymond R. Tice

  • U.S. Environmental Protection Agency Research Triagle Park, USA

    Michael D. Waters

Bibliographic Information

  • Book Title: Aneuploidy

  • Book Subtitle: Etiology and Mechanisms

  • Editors: Vicki L. Dellarco, Peter E. Voytek, Alexander Hollaender, B. R. Brinkley, Ernest B. Hook, Montrose J. Moses, Frederick J. Serres, T. C. Hsu, Liane B. Russell, Raymond R. Tice, … Michael D. Waters

  • Series Title: Basic Life Sciences

  • DOI: https://doi.org/10.1007/978-1-4613-2127-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1985

  • Softcover ISBN: 978-1-4612-9257-9Published: 08 October 2011

  • eBook ISBN: 978-1-4613-2127-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 562

  • Topics: Human Genetics

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