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Myocardial Ischemia

Proceedings of a Satellite Symposium of the Thirtieth International Physiological Congress July 8–11, 1986, Winnipeg, Canada

  • Conference proceedings
  • © 1987

Overview

Editors:
  1. Naranjan S. Dhalla

    1. Youville Research Institute, St. Boniface General Hospital, and Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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  2. Ian R. Innes

    1. Youville Research Institute, St. Boniface General Hospital, and Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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  3. Robert E. Beamish

    1. Youville Research Institute, St. Boniface General Hospital, and Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 67)

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Table of contents (28 papers)

  1. Front Matter

    Pages i-xiv
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  2. Myocardial Cell Damage and Arrhythmias

    1. Front Matter

      Pages 1-1
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    2. Ultrastructural Abnormalities in Ischemic Heart Disease

      • Jutta Schaper
      Pages 3-9

    3. Preconditioning with Ischemia: A Means to Delay Cell Death in Ischemic Myocardium

      • Charles E. Murry, Robert B. Jennings, Keith A. Reimer
      Pages 11-20

    4. Modification of the Thromboxane/Prostacyclin Balance as an Approach to Antiarrhythmic Therapy During Myocardial Ischaemia and Reperfusion; The Concept of Endogenous Antiarrhythmic Substances

      • James R. Parratt
      Pages 21-35

    5. Mechanisms of Coupled Arrhythmias in Guinea Pig Perfused Heart and Isolated Ventricular Tissue Models of Ischemia-Reperfusion

      • Gregory R. Ferrier, C. M. Guyette
      Pages 37-51

    6. The Preventive Effect of Sodium Selenite Against Ischemic Ventricular Arrhythmia and Some Clues to its Mechanisms

      • Y. A. Mei, Y. Q. Xu, H. D. Zhang
      Pages 53-63

  3. Pathophysiologic Aspects of Ischemic Injury

    1. Front Matter

      Pages 65-65
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    2. Molecular Events Occurring During Post-Ischaemic Reperfusion

      • R. Ferrari, C. Ceconi, S. Curello, A. Cargnoni, A. Albertini, E. O. Visioli
      Pages 67-84

    3. Oxidation of Methionine in Proteins of Isolated Rat Heart Myocytes and Tissue Slices by Neutrophil-Generated Oxygen Free Radicals

      • H. Fliss, G. Docherty
      Pages 85-98

    4. Phospholipid Metabolism in Heart Membranes

      • K. J. Kako, M. Kato
      Pages 99-112

    5. Models of Injury of Cardiovascular Membranes by Amphiphiles and Free Radicals

      • W. B. Weglicki, I. T. Mak, B. F. Dickens, J. H. Kramer
      Pages 113-122

    6. Inability of Superoxide Dismutase and Catalase to Inhibit Calcium Influx on Reoxygenation of Rabbit Myocardium

      • P. A. Poole-Wilson, M. A. Tones
      Pages 123-131

    7. Catecholamine Release in Myocardial Ischemia and Its Clinical Implications

      • W. Kübler, R. Dietz, W. Mäurer, A. Schömig
      Pages 133-143

    8. Coronary Blood Flow in Myocardial Stress with Catecholamine Administration in the Dog

      • R. M. Berne, J. M. Gidday, H. E. Hill, R. Rubio
      Pages 145-148

    9. Morphometric Analysis of Regional Myocardial Perfusion in Rats as Measured by Non-Radioactive Microspheres

      • M. Korpan, K. Rakusan
      Pages 149-161

    10. Prostaglandins and Defects in Vascular Function

      • Dennis B. McNamara, John A. Bellan, Philip R. Mayeux, Morris D. Kerstein, Albert L. Hyman, Philip J. Kadowitz et al.
      Pages 163-170

    11. Endothelium Dependent Relaxation and Atherosclerosis

      • N. Sreeharan, R. Jayakody, M. Senaratne, A. Thomson, T. Kappagoda
      Pages 171-182

  4. Metabolic Aspects of Cell Damage

    1. Front Matter

      Pages 183-183
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    2. Energy Metabolism in Myocardial Ischemia and Reperfusion

      • Robert B. Jennings, Keith A. Reimer, Charles Steenbergen, Charles E. Murry
      Pages 185-198
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Keywords

About this book

Whenever the coronary flow is inadequate to provide enough oxygen to meet the energy demands of the tissue, the heart becomes ischemic. Manifestations of myocardial ischemia include depression in contractile activity, changes in metabolic pattern, abnormalities in ultrastructure, and alterations in membrane potential. Ischemic changes during the early phase are reversible but as the period of ischemia is extended, the injury becomes irreversible. The transition from reversible to irreversible ischemic injury is usually associated with some membrane defects. It is worthwhile to consider that the irreversible damage to the ischemic myocardium occurs when the sarcolemmal membrane is altered in suoh a way that it would promote 2 a net gain of ca + in the cardiac cell upon reinstitution of blood flow. Suoh a lesion could result when mechanisms for the entry as well as removal 2 of ca + from the myocardial oell become defective. In this regard, 2 depression of the sarcolemmal ca + pump would favour the oocurrenoe of 2 intracellular ca + overload. Furthermore, inhibition of the Na+-K+ pump would lead to elevation of myoplasmic Na+ which oould then increase the 2 2 intracellular concentration of ca + through the sarcolemmal Na+-ca + exchange mechanism. In faot recent studies have revealed an inhibition of 2 the sarcolemmal Na+-ca + exchange mechanism in the ischemic heart and this 2 change could also contribute towards the occurrence of intracellular ca + 2 overload.

Editors and Affiliations

  • Youville Research Institute, St. Boniface General Hospital, and Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla, Ian R. Innes, Robert E. Beamish

Bibliographic Information

  • Book Title: Myocardial Ischemia

  • Book Subtitle: Proceedings of a Satellite Symposium of the Thirtieth International Physiological Congress July 8–11, 1986, Winnipeg, Canada

  • Editors: Naranjan S. Dhalla, Ian R. Innes, Robert E. Beamish

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-1-4613-2055-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 1987

  • Softcover ISBN: 978-1-4612-9221-0Published: 28 August 2013

  • eBook ISBN: 978-1-4613-2055-5Published: 11 November 2013

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XIV, 353

  • Number of Illustrations: 48 b/w illustrations

  • Topics: Cardiology

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