Overview
- Editors:
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Elliot Elson
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Washington University School of Medicine, St. Louis, USA
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William Frazier
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Washington University School of Medicine, St. Louis, USA
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Luis Glaser
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University of Miami, Coral Gables, USA
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Table of contents (8 chapters)
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Front Matter
Pages i-xiii
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- Jean-Loup Duband, Thierry Darribère, Jean-Claude Boucaut, Habib Boulekbache, Jean Paul Thiery
Pages 1-53
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- Richard A. Majack, Paul Bornstein
Pages 55-77
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- Gregory J. Cole, Richard W. Bond
Pages 79-111
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- Barry R. Ganong, Carson R. Loomis, Yusuf A. Hannun, Robert M. Bell
Pages 183-214
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- James R. Woodgett, Tony Hunter, Kathleen L. Gould
Pages 215-340
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- Chitra Biswas, Bryan P. Toole
Pages 341-363
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- Paul L. McNeil, D. Lansing Taylor
Pages 365-405
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Back Matter
Pages 407-417
About this book
This volume assembles reviews on topics in two major related areas. One of these concerns the interactions of cells with substrata and with other cells, which are mediated by the extracellular matrix and soluble molecules. As described in this volume, these interactions are responsible for controlling cell functions ranging from embryogenesis and neural development to blood clotting. More over, important properties of the extracellular matrix can be modulated by the interdependent actions of tumor cells and fibroblasts. The other major area of interest concerns the response of cells to extracellular signals. Recent work has begun to reveal how a remarkable diversity of cellular functions, including neuronal, proliferative, membrane--cytoskeletal, and many other kinds of re sponses, are elicited through the mediation of a relatively small and interdepen dent set of second messenger systems. These include both changes in cytoplasmic ionic balances and activation of various kinds of protein kinases. Both subjects are covered in this volume. The two areas are linked by the common theme of cellular response to an external environment that is sensed through cellular interactions with informational molecules, which are soluble agents, as well as those that are components of insoluble matrices. It is only recently that we have come to appreciate the complex interplay between the matrix surrounding a cell and the cell's response to hormones and growth factors. Thus, we have tried to select examples in which this type of extracellular integration may playa role.
