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Breast Cancer: Scientific and Clinical Progress

Proceedings of the Biennial Conference for the International Association of Breast Cancer Research, Miami, Florida, USA — March 1–5, 1987

  • Conference proceedings
  • © 1988

Overview

Editors:
  1. Marvin A. Rich

    1. AMC Cancer Research Center, Denver, USA

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  2. Jean C. Hager

    1. AMC Cancer Research Center, Denver, USA

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  3. Diana M. Lopez
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Part of the book series: Developments in Oncology (DION, volume 56)

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Table of contents (25 papers)

  1. Front Matter

    Pages i-xix
    Download chapter PDF

  2. Oncogenes/Growth Factors—Their Role in Breast Cancer

    1. An Analysis of Three Proto-Oncogenes in Primary Human Breast Tumor DNAs: The c-mos, the c-erbB-2 and the Epidermal Growth Factor Receptor Genes

      • N. E. Hynes, S. Kozma, S. Saurer, B. Groner, G. Locher
      Pages 1-10

    2. Proviral Activation of Potential Oncogenes in Tumors Induced by Mouse Mammary Tumor Virus

      • Gordon Peters, Clive Dickson
      Pages 11-23

    3. Quantitative and Qualitative Changes in Oncogene Expression During Carcinogenesis

      • D. A. Spandidos, A. Pintzas, A. Kakkanas, M. Yiagnisis, N. J. Agnantis
      Pages 24-41

    4. Mammary Tumor-Associated Growth Factors Origins and Possible Functions

      • W. R. Kidwell, D. S. Salomon
      Pages 42-54

    5. The Oestrogen-Induced pS2 Gene and the Oestrogen Receptor in Breast Cancer

      • P. Chambon, G. Stack, M. C. Rio, M. Berry, A. M. Nunez, V. Kumar et al.
      Pages 55-67

    6. Synopsis of Workshop IV: Oncogenes and Chemical Effectors of Neoplastic Transformation

      • M. R. Banerjee, S. Nandi
      Pages 68-87

  3. Mammary Gland Development, Differentiation and Pathology in Relationship to Malignancy

    1. Immunological Markers in the Study of the Development of the Mouse Mammary Gland and Its Tumors

      • A. Sonnenberg, J. Daams, F. Delemarre, P. Lens, J. Hilgers
      Pages 88-111

    2. Cloning the Polymorphic Gene for the Mammary Mucin Abnormally Glycosylated in Carcinomas

      • S. Gendler, J. Burchell, A. Girling, R. Millis, T. Duhig, J. Taylor-Papadimitriou
      Pages 112-126

    3. Regulation of Tissue-Specific Gene Expression in the Mammary Gland: The Role of the Extracellular Matrix

      • Mina J. Bissell, Judith Aggeler
      Pages 127-141

    4. The Possible Role of Abnormal Fibroblasts in the Pathogenesis of Breast Cancer

      • S. L. Schor, A. M. Schor, A. Howell, J. Haggie
      Pages 142-157

    5. Myoepithelial and Endocrine Differentiation in Breast Carcinoma

      • G. Bussolati, M. Papotti, A. Sapino, P. Gugliotta, L. Macri’
      Pages 158-173

    6. Human Monoclonal Antibodies Directed Against Viral Antigens

      • N. I. Smorodinsky, I. Tsarfaty, Y. Ghendler, R. Lupu, I. Keydar, S. Argov et al.
      Pages 174-184

    7. Cytotoxic Effector Mechanisms Involved in the Immunity Against Mammary Tumors

      • Diana M. Lopez, Ranga R. Padmanabhan, Lourdes M. Rivera, Ronald D. Paul, Lynn Herbert, Carolyn Cray et al.
      Pages 185-205

    8. Mesenchymal-Epithelial Interactions in Normal and Malignant Mammary Cells

      • Adeline J. Hackett, Helene S. Smith, Robert Stern
      Pages 206-212

    9. Breast Cancer Differentiation and Progression: Analysis with Monoclonal Antibodies Flow Cytometry

      • J. Hilgers, J. Taylor-Papadimitriou
      Pages 213-222

  4. New Developments in Clinical Applications

    1. Mammary Epithelial Antigens as a Breakthrough in Breast Cancer Research: Now Where to?

      • Roberto L. Ceriani
      Pages 223-261

    2. CA15-3 and Related Antigens as Serum Markers for Monitoring Breast Cancer

      • D. W. Kufe, D. Hayes, M. Abe, T. Ohno
      Pages 262-273

    3. Nuclear DNA Content and Prognosis in Breast Cancer

      • A. Fallenius, G. Auer
      Pages 274-284

    4. Perspectives for the Clinical Use of Aromatase Inhibitors

      • Richard J. Santen
      Pages 285-298
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Keywords

About this book

Effective control of breast cancer depends on three types of research accomplishment -- understanding the disease's origins and progression: successfully applying this knowledge to methods of detection, diagnosis and treatment: and finding ways to make these advances truly available to the public as effectively as possible. The significant progress that is occurring across this entire spectrum of pioneering investigation is reflected in these proceedings of the 1987 biennial conference of the International Association for Breast Cancer Research. The first section of the book focuses on oncogenes and chemical effectors that may play key roles in early cell transformation leading to breast cancer. Research discussed includes identification of specific oncogenes which appear to be involved in the disease, study of their activation and expression, examination of the biological effects of various growth factors isolated from breast cancer cell lines, and investigation of the molecular mechanisms by which estrogens promote and stimulate growth of breast cancers. The second group of chapters deals with several other complex factors and phenomena which may influence tumor formation in the breast, for example, expression of abnormalities by fibroblasts, disruption of epithelial-mesenchymal interactions, and loss of ability nili to synthesize normal basal lamina resulting in alterations in the extracellular matrix. Clarification of the processes of normal mammary gland development and differentiation is central to much of this work.

Editors and Affiliations

  • AMC Cancer Research Center, Denver, USA

    Marvin A. Rich, Jean C. Hager

Bibliographic Information

  • Book Title: Breast Cancer: Scientific and Clinical Progress

  • Book Subtitle: Proceedings of the Biennial Conference for the International Association of Breast Cancer Research, Miami, Florida, USA — March 1–5, 1987

  • Editors: Marvin A. Rich, Jean C. Hager, Diana M. Lopez

  • Series Title: Developments in Oncology

  • DOI: https://doi.org/10.1007/978-1-4613-1753-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers, Boston 1988

  • Hardcover ISBN: 978-0-89838-387-4Published: 31 August 1988

  • Softcover ISBN: 978-1-4612-8984-5Published: 05 October 2011

  • eBook ISBN: 978-1-4613-1753-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIX, 389

  • Topics: Oncology, Cancer Research

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