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Silent Myocardial Ischemia

Proceedings of the Symposium on New Drugs and Devices October 15–16, 1987, Philadelphia, Pennsylvania

  • Conference proceedings
  • © 1988

Overview

Editors:
  1. Joel Morganroth

    1. Likoff Cardiovascular Institute, Hahnemann Medical College and Hospital, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. E. Neil Moore

    1. School of Veterinary Medicine, University of Pennsylvania, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 88)

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Table of contents (14 papers)

  1. Front Matter

    Pages i-xiii
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  2. Epidemiology, Pathophysiology, Classification

    1. Front Matter

      Pages 1-1
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    2. Epidemiology and Prevalence of Silent Myocardial Ischemia, and Prognosis in Asymptomatic Patients

      • Peter F. Cohn
      Pages 3-5

    3. Pathophysiology of Ischemia: Why are Some Episodes Silent?

      • Carl Pepine
      Pages 7-15

    4. Myocardial Ischemia as a Useful Functional Indicator of Risk in Patients with Coronary Artery Disease

      • Andrew P. Selwyn, Khether Raby, Joan Barry, Michael B. Rocco, Kimberely Meade, Charles Treasure
      Pages 17-23

    5. The Diagnostic and Prognostic Value of Exercise ECG and Radionuclide Markers of Ischemia in Asymptomatic and Symptomatic Populations

      • Robert S. Gibson
      Pages 25-38

    6. An Integrated Clinical Classification for Ischemic Heart Disease: A Combined Assessment of Severity of Coronary Disease, Left Ventricular Function and Myocardial Ischemia

      • Sidney O. Gottlieb
      Pages 39-54

  3. Back Matter

    Pages 55-74
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  5. Back Matter

    Pages 107-114
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  6. Trial Designs

    1. Front Matter

      Pages 115-115
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    2. Longitudinal (Natural History) Studies of Silent Myocardial Ischemia

      • J. Thomas Bigger Jr., The MSSMI Investigators
      Pages 117-130

    3. Silent Myocardial Ischemia and Sudden Cardiac Death

      • Leonard N. Horowitz
      Pages 131-138

  7. Back Matter

    Pages 139-143
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  8. Therapy and FDA Claims

    1. Front Matter

      Pages 145-145
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    2. Antianginal Drug Therapy for Silent Myocardial Ischemia: Adrenergic Blockers and Calcium Entry Blockers

      • William H. Frishman
      Pages 147-161

    3. Therapy For Silent Ischemia: Nitrates

      • Stephen Scheidt
      Pages 163-178
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Keywords

About this book

Although some investigators have questioned the importance and even the existence of silent myocardial ischemia, documentation presented at this two day symposium leaves little doubt about its existence and importance. It has been estimated that about 3 million of the estimated 4 million angina sufferers in the United states have frequent episodes of silent myocardial ischemia. Although it is not possible to define how many Americans die due to silent ischemia, it has been suggested that the mortality rate may exceed hundreds of thousands of victims annually. Unfortunately, there still remains a lack of definitive information as to why some ischemic events are painless. Some suggest the concept that the location and size of the myocardium at jeopardy relates to pain, that the pain threshold varies from patient to patient or that there are neurological deficits in the myocardium of some patients with silent ischemia. Abnormalities in myocardial perfusion and function can occur without pain. An interesting observation presented by several investigators has been that when a coronary artery is occluded in man, no ischemic pain is perceived for the first 30 seconds. Only after a 30 second period or so of occlusion does angina occur. An even more confusing observation is that some 30 second periods of occlusion of the same vessel in the same patient results in angina while the next occlusion can be a totally silent event.

Editors and Affiliations

  • Likoff Cardiovascular Institute, Hahnemann Medical College and Hospital, USA

    Joel Morganroth

  • School of Veterinary Medicine, University of Pennsylvania, USA

    E. Neil Moore

Bibliographic Information

  • Book Title: Silent Myocardial Ischemia

  • Book Subtitle: Proceedings of the Symposium on New Drugs and Devices October 15–16, 1987, Philadelphia, Pennsylvania

  • Editors: Joel Morganroth, E. Neil Moore

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-1-4613-1745-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers, Boston 1988

  • Hardcover ISBN: 978-0-89838-380-5Published: 30 June 1988

  • Softcover ISBN: 978-1-4612-8980-7Published: 22 January 2012

  • eBook ISBN: 978-1-4613-1745-6Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XIV, 242

  • Topics: Cardiology

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