Pathophysiology and Pharmacology of Heart Disease

1. Front Matter

   Pages i-xiii

   PDF

2. The Newborn Pig Heart, a Superior Animal Model of Cardiac Hypertrophy

   • Howard E. Morgan

   Pages 1-7

3. Subcellular Alterations in Hypertrophied Pig Heart Due to Pressure Overload

   • N. S. Dhalla, V. Panagia, C. E. Heyliger, V. Elimban, K. S. Dhalla, P. K. Singal

   Pages 9-17

4. Cardiac Sarcolemmal Vesicles: ATP-Dependent Ca Ion Transport and Inhibition of Protein Kinase Reactions by Amrinone

   • Roland Vetter, Hannelore Haase, Liane Will-Shahab

   Pages 19-33

5. Transient Changes in Cyclic AMP and in Protein Kinase and Phosphorylase Activity During the Cardiac Cycle in the Canine Myocardium and the Effect of Propranolol

   • E.-G. Krause, Sabine Bartel, Inge Beyerdorfer, W. Freier, K. Gerber, D. Obst

   Pages 35-44

6. The Role of Creatine Kinase and Adenylate Systems in the Integration of Oxidative Phosphorylation and Contractile Function in the Heart

   • V. V. Kupriyanov, V. L. Lakamkin, A. Ya. Steinschneider, N. A. Novikova, V. A. Saks, V. I. Kapelko

   Pages 45-56

7. The Action of Calcium Channel Agonists on the Mammalian Ventricular Myocardium

   • D. Bose, L. V. Hryshko, J. K. Saha, R. A. Bouchard, T. Chau

   Pages 57-68

8. Calcium and Reperfusion Damage in Heart Muscle

   • Philip A. Poole-Wilson

   Pages 69-79

9. Cardioplegia and Cellular Calcium Homeostasis

   • J. S. Juggi, A. M. Yousof, Hani J. Shuhaiber, A. G. H. Abdulla, K. S. Bhatia

   Pages 81-90

10. Role of Oxygen in Myocardial Ischaemia and Reperfusion Damage

    • R. Ferrari, C. Ceconi, S. Curello, A. Cargnoni, F. De Giuli, G. M. Boffa et al.

    Pages 91-107

11. Calcium Channel Blockers in Experimental Myocardial Infarction

    • S. D. Seth, S. K. Maulik

    Pages 109-123

12. New Trends in Protection from Life-Threatening Arrhythmias

    • L. Szekeres, M. Németh, J. Gy. Papp, Z. Szilvássy, É. Udvary, Á. Végh

    Pages 125-134

13. The Role of the Blood Pressure in the Mechanism of Congestive Cardiac Failure

    • P. Harris

    Pages 135-143

14. Untreated Congestive Heart Failure Studies of Mechanisms

    • I. S. Anand, R. Ferrari, G. S. Kalra, P. L. Wahi, P. A. Poole-Wilson, P. Harris

    Pages 145-156

15. Hyponatremia in Congestive Heart Failure

    • C. T. G. Flear

    Pages 157-169

16. Dietary N-3 Fatty Acids and Ischaemic Heart Disease

    • J. M. J. Lamers, L. M. A. Sassen, J. M. Hartog, P. D. Verdouw

    Pages 171-181

17. Atherosclerosis in a Monkey Model

    • R. N. Chakravarti

    Pages 183-196

18. Abnormalities of Adrenergic Mechanisms in Diabetic Cardiomyopathy

    • P. K. Ganguly, R. E. Beamish, I. R. Innes, N. S. Dhalla

    Pages 197-203

19. Circulatory Response to High Altitude

    • S. C. Manchanda

    Pages 205-213

20. Reversible Effects of Focused Ultrasound on Myocardium

    • K. Yu Bogdanov, S. I. Zakhrov, L. V. Rosenshtraukh

    Pages 215-223

Research at the molecular and the cellular level has greatly enhanced our understanding of the pathogenesis and management of heart disease. Valuable contributions, towards this end, have been made by scientists from different dis­ ciplines including biochemistry, physiology, pathology, molecular biology and biophysics. We felt that it would be of interest and value to bring together ex­ perts from diverse specialities to present their work and to discuss the common problems encountered in their endeavours. In accordance, a symposium was organised in February 1988 at the Postgraduate Institute of Medical Education & Research, Chandigarh. It was held during the annual meeting of the Indian section of the International Society for Heart Research. This book is a compila­ tion of some of the papers presented at the symposium. The symposium was sponsored by the Council on Cardiac Metabolism of the International Society and Federation of Cardiology. A number of Indian or­ ganisations gave generous financial help. These included the National Academy of Medical Sciences, Indian Council of Medical Research, Council of Scientific and Industrial Research and Department of Science and Technology. Desktop publishing was used to prepare this volume. In doing so we came to appreciate the remarkable qualities, skills and help rendered by Professor Dharam Vir. For typing the manuscripts and for other secretarial assistance we gratefully acknowledge the help of Ravinder and Sawtantar. PATHOPHYSIOLOGY AND PHARMACOLOGY OF HEART DISEASE 1 THE NEWBORN PIG HEART, A SUPERIOR ANIMAL MODEL OF CARDIAC HYPERTROPHY Howard E.

• atherosclerosis
• biochemistry
• blood pressure
• calcium
• heart
• metabolism
• pathophysiology
• physiology
• research
• ultrasound

• Postgraduate Institute of Medical Education & Research, Chandigarh, India

  Inder S. Anand, Purshotam L. Wahi

• St. Boniface General Hospital Research Center, Winnipeg, Canada

  Naranjan S. Dhalla

Policies and ethics