Drug Resistance in Cancer Therapy

1. Front Matter

   Pages i-xiii

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2. Drug resistance: The clinical problem

   • Robert C. Young

   Pages 1-12

3. Mathematical models of drug resistance and chemotherapy effects

   • James H. Goldie

   Pages 13-26

4. Multidrug resistance in human tumors

   • Antonio T. Fojo

   Pages 27-36

5. Structure and function of P-glycoprotein

   • James H. Gerlach

   Pages 37-53

6. Anthracycline resistance

   • Alok Bhushan, John C. Kermode, James Posada, Thomas R. Tritton

   Pages 55-72

7. Circumvention of drug resistance with calcium channel blockers and monoclonal antibodies

   • Takashi Tsuruo

   Pages 73-95

8. P-glycoprotein in breast cancer

   • Douglas E. Merkel, Suzanne A. W. Fuqua, William L. McGuire

   Pages 97-105

9. Phosphoprotein, protein kinase C, and second-messenger system changes in human multidrug-resistant cancer cells

   • Robert L. Fine, Marti Jett, Jitendra Patel, James Carmichael, Change-Ho Ahn

   Pages 107-123

10. Alkylating agent resistance

    • Margie L. Clapper, Kenneth D. Tew

    Pages 125-150

11. Mechanisms of resistance to cisplatin and alkylating agents

    • Thomas C. Hamilton, Gi-Ming Lai, Mace L. Rothenberg, Antonio T. Fojo, Robert C. Young, Robert F. Ozols

    Pages 151-169

12. Glutathione S—transferase and drug resistance

    • Lorraine A. Cazenave, Jeffrey A. Moscow, Charles E. Myers, Kenneth H. Cowan

    Pages 171-187

13. Tumor cell drug and radiation resistance: Does an interrelationship exist?

    • James B. Mitchell, Angelo Russo, John A. Cook, Eli Glatstein

    Pages 189-203

14. Back Matter

    Pages 205-210

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Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfor­ tunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung can­ cer, genitourinary cancer, and pediatric oncology; second, by asking emi­ nent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

• Staging
• Tumor
• breast cancer
• calcium
• cancer
• cancer therapy
• cancer treatment
• cell
• chemotherapy
• diagnosis
• drug
• drug resistance
• radiation
• research
• resistance
• Radiaton Oncology

`This book would be a helpful text for basic researchers, clinical investigators, and medical housestaff. It is well written and can be read in a relatively short period.'
Breast Cancer Research and Treatment, 19, 1991
` The book is an exciting survey of the potential application of laboratory data. It is a good example of interdisciplinary research collaboration. It is recommended reading for those engaged in the development of new treatment strategies.'
Oncology, 48/1

• Fox Chase Cancer Center, Philadelphia, USA

  Robert F. Ozols

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