The Cerebrospinal Fluid

1. Front Matter

   Pages i-xiv

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2. A Brief History of the Understanding of Cerebrospinal Fluid

   • Robert M. Herndon

   Pages 1-13

3. Anatomic and Physiologic Aspects of the Cerebrospinal Fluid Space

   • Roger A. Brumback

   Pages 15-43

4. Abnormalities of Cerebrospinal Fluid Production and Flow and Hydrocephalus

   • Richard W. Leech

   Pages 45-96

5. Collecting Cerebrospinal Fluid

   • Roger A. Brumback

   Pages 97-130

6. The Medical Uses of Injection into the Cerebrospinal Fluid Space (Intrathecal and Intraventricular Injection)

   • Robert M. Herndon

   Pages 131-141

7. Cerebrospinal Fluid Infections

   • Michael Graves

   Pages 143-165

8. Nonimmunoglobulin Proteins in Human Cerebrospinal Fluid

   • Benjamin Rix Brooks

   Pages 167-178

9. Human Cerebrospinal Fluid Immunology

   • John L. Trotter, Robert S. Rust

   Pages 179-226

10. Light Microscopic Cytology of Cerebrospinal Fluid

    • Claire E. Meena, William H. Olson, Lung T. Yam

    Pages 227-244

11. The Cytology of Cerebrospinal Fluid: Methods and Normal Constituents

    • Robert M. Herndon, Roger A. Brumback

    Pages 245-260

12. Cytopathology of the Cerebrospinal Fluid

    • Robert M. Herndon, Roger Brumback

    Pages 261-300

13. Back Matter

    Pages 301-306

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For centuries the great minds of medical science puzzled over the importance of the cerebrospinal fluid. As far back as Hippocrates, it was thought that this "phlegm" that flooded the intracranial contents had pathological significance. However, not until the late 1800s, when Quincke introduced and popularized lumbar puncture, did physicians take an interest in the study of this fluid in relation to clinical illness. Since then a variety of techniques for obtaining cerebrospinal fluid from various sites have developed, and the relationship of cerebrospinal fluid to a variety of disease processes has received considerable study. In this volume, we have attempted to assemble reviews of some of these important developments during the past century. Chapter 1 contains a historical review of key investigations that helped shape our concepts of cerebrospinal fluid from the earliest recorded description by the author of the Edwin Smith Surgical Papyrus in the seventeenth century B. C. to contemporaries such as Kabat, Glusman, and Knaub, who introduced quantitative determinations of cerebrospinal fluid gamma globulin levels. In Chapter 2 there is a description of our current understanding of the anatomical compartment for the cerebrospinal fluid and the physiology of its formation, circulation, and absorption. Dr. Richard Leech in Chapter 3 contributes a comprehensive description of the disorders associated with excessive quanti­ ties of cerebrospinal fluid-commonly referred to as hydrocephalus. A variety of techniques for properly collecting and evaluating cerebrospinal fluid are detailed in Chapter 4.

• Hydrocephalus
• cytology
• cytopathology
• infection
• infections
• infectious diseases

• Oregon Health Sciences University, Portland, USA

  Robert M. Herndon

• Good Samaritan Hospital, Portland, USA

  Robert M. Herndon

• University of Oklahoma College of Medicine, Oklahoma City, USA

  Roger A. Brumback

• Laboratory Service, Veterans Administration Medical Center, Oklahoma City, USA

  Roger A. Brumback

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