Cancer Imaging with Radiolabeled Antibodies

1. Front Matter

   Pages i-xxi

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2. Historical and Theoretical Perspectives

   1. Front Matter

      Pages 1-1

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   2. Clinical radioimmunodetection: The second decade

      • David M. Goldenberg

      Pages 3-9

   3. Antibody targeting: Theoretical considerations

      • Arthur Bradwell, Peter Dykes, Gillian Thomas

      Pages 11-25

3. Model Systems

   1. Front Matter

      Pages 27-27

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   2. Experimental model systems for antibody targeting and radioimmunodetection

      • Rosalyn D. Blumenthal, Robert M. Sharkey, David M. Goldenberg

      Pages 29-52

   3. Preclinical models and methods for the study of radiolabeled monoclonal antibodies in cancer diagnosis and therapy

      • Sudhir A. Shah, Howard Sands

      Pages 53-96

   4. Physiology of monoclonal antibody accretion by tumors

      • Howard Sands, Peter L. Jones

      Pages 97-122

   5. Intraperitoneal delivery of monoclonal antibodies

      • Richard L. Wahl

      Pages 123-149

4. Radiochemistry

   1. Front Matter

      Pages 151-151

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   2. Chelates and antibodies: Current methods and new directions

      • Otto A. Gansow, Martin W. Brechbiel, Saed Mirzadeh, David Colcher, Mario Roselli

      Pages 153-171

   3. Radiolabeling antibodies via the cyclic anhydride of DTPA — Experiences of 5 years

      • D. J. Hnatowich

      Pages 173-181

   4. Bifunctional chelating agents for radiometal-labeled monoclonal antibodies

      • Ramaswamy Subramanian, Claude F. Meares

      Pages 183-199

   5. Optimization of biodistribution by introducing different chemical linkages between antibody and an indium-111 chelate

      • Syed M. Quadri, Chang H. Paik, Richard C. Reba, Won-Pyo Hong

      Pages 201-213

   6. Novel bifunctional linkers for antibody chelation with radiometals

      • Robert Sundoro Wu

      Pages 215-232

   7. Labeling of anti-tumor antibodies and antibody fragments with Tc-99m

      • Hans J. Hansen, Anastasia L. Jones, Ruth Grebenau, Arthur Kunz, David M. Goldenberg

      Pages 233-244

5. Clinical Studies

   1. Front Matter

      Pages 245-245

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   2. Requirements for the use of radioimmunodetection of cancer in clinical practice

      • Gianluigi Buraggi

      Pages 247-271

   3. In-vivo antibody imaging for the detection of human tumors

      • David M. Goldenberg, Hildegard Goldenberg, Robert M. Sharkey, Robert E. Lee, Jo Ann Horowitz, Thomas C. Hall et al.

      Pages 273-292

   4. In-111 monoclonal antibody immunoscintigraphy of colorectal cancer

      • Lamk M. Lamki, Yehuda Z. Patt, James L. Murray

      Pages 293-312

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology text­ books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

• Antigen
• Staging
• Tumor
• carcinoma
• diagnosis
• imaging
• interferon
• physiology
• surgery

` It is recommended for laboratory investigators who seek detailed information on many of the important issues in radioimmunodetection research and for clinical investigators active in this area, who will benefit from comparing a variety of viewpoints on the major problems that still need to be solved.'
Cancer Cells, 3:1, 1991

• Center for Molecular Medicine and Immunology, University of Medicine and Dentistry of New Jersey, Newark, USA

  David M. Goldenberg

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