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Drug Resistance

  • Book
  • © 1996

Overview

Editors:
  1. William N. Hait

    1. The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, USA
      Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, USA
      Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, USA

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Part of the book series: Cancer Treatment and Research (CTAR, volume 87)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Membrane Transport Mechanisms

    1. Front Matter

      Pages 1-1
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    2. P-Glycoprotein-Mediated Multidrug Resistance: Experimental and Clinical Strategies for its Reversal

      • James M. Ford, Jin-Ming Yang, William N. Hait
      Pages 3-38

    3. Multidrug Resistance Associated with Overexpression of MRP

      • Susan P. C. Cole, Roger G. Deeley
      Pages 39-62

  3. Resistance to Alkylating Agents

    1. Front Matter

      Pages 63-63
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    2. Mechanisms of Resistance to Alkylating Agents

      • Philip G. Penketh, Krishnamurthy Shyam, Alan C. Sartorelli
      Pages 65-81

    3. Glutathione S-Transferases

      • Abhijit Raha, Kenneth D. Tew
      Pages 83-122

    4. Role of DNA Repair in Resistance to Drugs that Alkylate O6 of Guanine

      • Omer N. Koç, Weldon P. Phillips Jr, Keunmyoung Lee, Lili Liu, Nasir H. Zaidi, James A. Allay et al.
      Pages 123-146

  4. Resistance to Microtubule Active Drugs

    1. Front Matter

      Pages 147-147
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    2. Paclitaxel (Taxol®) Mechanisms of Resistance

      • Anna M. Casazza, Craig R. Fairchild
      Pages 149-171

  5. Resistance to Antimetabolites

    1. Front Matter

      Pages 173-173
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    2. Mechanisms of Clinical Resistance to 5-Fluorouracil Chemotherapy

      • Edward Chu, Carmen J. Allegra
      Pages 175-195

    3. Antifolates: Current Developments

      • Elizabeth A. Rayl, Giuseppe Pizzorno
      Pages 197-223

    4. Human Immunodeficiency Virus Replication in the Presence of Antiretroviral Drugs: Analogies to Antineoplastic Drug Resistance

      • Roger K. Strair, Daniel J. Medina
      Pages 225-239

  6. Topoisomerases

    1. Front Matter

      Pages 241-241
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    2. Cellular Resistance to Topoisomerase Poisons

      • Eric H. Rubin, Tsai-Kun Li, Pu Duann, Leroy F. Liu
      Pages 243-260

  7. Resistance to Endocrine Therapies

    1. Front Matter

      Pages 261-261
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    2. Acquisition of an Antiestrogen-Resistant Phenotype in Breast Cancer: Role of Cellular and Molecular Mechanisms

      • Robert Clarke, Todd Skaar, Fabio Leonessa, Brenda Brankin, Mattie James, Nils Brünner et al.
      Pages 263-283

    3. Androgen Receptor Mutations in Prostate Cancer

      • Edward P. Gelmann
      Pages 285-302

  8. Resistance to Retinoids

    1. Front Matter

      Pages 303-303
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Keywords

About this book

Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time.
In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.

Editors and Affiliations

  • The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, USA

    William N. Hait

  • Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, USA

    William N. Hait

  • Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, USA

    William N. Hait

Bibliographic Information

  • Book Title: Drug Resistance

  • Editors: William N. Hait

  • Series Title: Cancer Treatment and Research

  • DOI: https://doi.org/10.1007/978-1-4613-1267-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1996

  • Hardcover ISBN: 978-0-7923-4022-5Published: 30 September 1996

  • Softcover ISBN: 978-1-4612-8540-3Published: 16 September 2011

  • eBook ISBN: 978-1-4613-1267-3Published: 06 December 2012

  • Series ISSN: 0927-3042

  • Series E-ISSN: 2509-8497

  • Edition Number: 1

  • Number of Pages: XVIII, 418

  • Topics: Oncology, Pharmacology/Toxicology

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