Overview
- Editors:
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Udho Thadani
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Health Sciences Center, University of Oklahoma, Oklahoma City, USA
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Lionel H. Opie
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University of Cape Town, Cape Town, South Africa
Division of Cardiology, Stanford University Medical Center, Stanford, USA
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Table of contents (11 chapters)
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- Kristina E. Torfgård, Johan Ahlner
Pages 21-56
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- Ho-Leung Fung, John Anthony Bauer
Pages 57-79
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- Udho Thadani, Raymond J. Lipicky
Pages 94-116
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- Udho Thadani, Raymond J. Lipicky
Pages 117-133
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- Udho Thadani, Lionel H. Opie
Pages 134-149
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- Henry Purcell, David Mulcahy, Kim Fox
Pages 175-190
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Back Matter
Pages 217-224
About this book
Nitrates remain among the most commonly used therapeutic agents in cardiology. That they can re lieve pain in angina pectoris has been known at least since 1867, when Lauder Brunton described their clinical use. Now, almost 130 years later, we are constantly learning more about their optimal use in anginal syndromes. For example, there is no doubt that nitrate tolerance occurs, but equally no doubt that certain drug dosages help to attenuate such toler ance. Thus, our understanding of nitrate tolerance has been taken further by the advent of new nitrate preparations and by studies at a basic science level. The current intense interest in nitrates has been rekindled by the growing emphasis on the role of the endothelium in the production of nitric oxide, a basic cardiovascular regulator. If nitric oxide is vasodilator and protects the vascular endothelium, then nitrates should also have similar properties. Hence this book starts off with the role of the endothelium and ni trates in vasodilation. Next, the mechanisms of ac tion of nitrates are considered with emphasis on the role of cyclic GMP. The chief limitation to the use of nitrates lies in nitrate tolerance. After carefully looking at all the evidence, the authors of the third chapter conclude that the mechanism is likely to be multifactorial. The mechanism responsible for the tolerance still remains unknown. In vitro tolerance may be due to enhanced production of vascular superoxide [1].
Editors and Affiliations
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Health Sciences Center, University of Oklahoma, Oklahoma City, USA
Udho Thadani
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University of Cape Town, Cape Town, South Africa
Lionel H. Opie
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Division of Cardiology, Stanford University Medical Center, Stanford, USA
Lionel H. Opie
