Calcium and Ion Channel Modulation

1. Front Matter

   Pages i-xxii

   PDF

2. Voltage-Activated Calcium Channels

   1. Front Matter

      Pages 1-1

      PDF

   2. Calcium Channel Diversity

      • Lou Byerly, Susumu Hagiwara

      Pages 3-18

   3. Multiple Types of Calcium Channels: Is their Function Related to their Localization?

      • Joachim W. Deitmer

      Pages 19-32

   4. Calcium Channels Incorporated into Planar Lipid Bilayers: Phenomenology, Pharmacology, and Phylogeny

      • Barbara E. Ehrlich, Michael Forte

      Pages 33-41

   5. Modulation of Ionic Selectivity of Ca Channels in the Neuronal Membrane by Ca Ions

      • Sergei L. Mironov

      Pages 43-51

   6. Proton-Induced Transformation of Ca2+ Channel in Dorsal Root Ganglion Neurons

      • Martin Morad, Hans Dieter Lux

      Pages 53-62

   7. Physiology of Multiple Calcium Channels

      • A. P. Fox, L. D. Hirning, D. V. Madison, E. W. McCleskey, R. J. Miller, M. C. Nowycky et al.

      Pages 63-74

   8. Expression of Presynaptic Calcium Channels in Xenopus Oocytes

      • Joy A. Umbach, Cameron B. Gundersen

      Pages 75-86

3. Intracellular Calcium and Cell Function: Sensory Transduction, Modulation of Excitability, and Neurosecretion

   1. Front Matter

      Pages 87-87

      PDF

   2. Control of a Light Emitting Photoprotein by Calcium Channels in a Hydrozoan Coelenterate

      • Kathleen Dunlap, Paul Brehm

      Pages 89-101

   3. Calcium in Photoreceptors

      • Gordon L. Fain, Walter H. Schrüder

      Pages 103-118

   4. Small Conductance Ca Activated K Channels in Mollusks

      • A. Hermann, C. Erxleben, D. Armstrong

      Pages 119-131

   5. Ca²⁺ Diffusion in the Cytoplasm of Aplysia Neurons: Its Relationship to Local Concentration Changes

      • Douglas Tillotson, Enrico Nasi

      Pages 133-146

   6. Fura-2 Imaging of Localized Calcium Accumulation Within Squid ‘Giant’ Presynaptic Terminal

      • Stephen J. Smith, Luis R. Osses, George J. Augustine

      Pages 147-155

   7. Toward a Molecular Understanding of Synaptic Transmitter Release: Physiological Clues from the Squid Giant Synapse

      • George J. Augustine, Milton P. Charlton, Stephen J. Smith

      Pages 157-168

   8. Quantal Classes and Subunits of Quanta in the Neuromuscular Junction

      • Mahlon E. Kriebel

      Pages 169-184

4. Ion Channel Modulation by Neurotransmitters and Second Messengers

   1. Front Matter

      Pages 185-185

      PDF

   2. Cytoplasmic Modulation of Ion Channel Functioning in the Neuronal Membrane

      • Platon G. Kostyuk

      Pages 187-195

   3. Control of the Generation and Removal of Calcium-Mediated Inactivation of the Calcium Current in Helix Aspersa Neurons

      • John Chad

      Pages 197-213

Cellular neurobiology has been transformed in the past decade by new technologies and fundamental discoveries. One result is an enormous increase in our understanding of how ion channels function in nerve and muscle cells and a widening perspective on the role of ion channels in non-neuronal cell physiology and development. Patch clamp techniques now permit direct observation of the transitions between functional confor­ mations of individual ion channels in their native membrane. Recombinant DNA techniques are being used to determine the primary structure of ion channel proteins and to test hypotheses about channel conformations, sites of grating and modulation, and the basis of ion selectivity. At the same time, biochemical techniques have revealed intricate signalling systems in­ side cells, involving second messengers such as calcium, phospholipids and cyclic nucleotides, which interface with the external milieu through GTP binding proteins and regulate cell metabolism by altering protein phos­ phorylation. This panorama of second messenger systems has greatly increas­ ed our application for their potential role in regulating ion channel function. We now recognize that ion channels are much more complicated than we once thought, and more interesting. They are not simply isolated macro­ molecules in the membrane, gated directly by depolarization or trans­ mitter binding to open briefly at a fixed conductance and then close or inactivate. Instead, individual channels now appear to have many open and closed states that are regulated independently by voltage and transmitters.

• DNA
• activation
• biology
• cell
• cell physiology
• escherichia coli
• growth
• membrane
• metabolism
• neurobiology
• neurotransmitter
• physiology
• proteins
• receptor
• regulation

• UCLA School of Medicine, Los Angeles, USA

  Alan D. Grinnell

• National Institute of Environmental Health Sciences, Research Triangle, USA

  David Armstrong

• University of California, Los Angeles, Los Angeles, USA

  Meyer B. Jackson

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