Cellular and Molecular Biology of Mammary Cancer

1. Front Matter

   Pages i-ix

   PDF

2. Mammary Epithelial Markers and Cell Lineages of Mammary Neoplasia

   1. Changes in Antigen Patterns During Development of the Mouse Mammary Gland: Implications for Tumorigenesis

      • J. Daams, A. Sonnenberg, T. Sakakura, J. Hilgers

      Pages 1-8

   2. Stem Cells in Mammary Development and Cancer

      • Philip S. Rudland

      Pages 9-28

   3. Structural Components as Markers of Differentiation and Neoplastic Progression in Mammary Epithelial Cells

      • Bonnie B. Asch, Harold L. Asch

      Pages 29-45

   4. Chromosomes in Breast Cancer

      • Sandra R. Wolman

      Pages 47-65

3. Extra Cellular Matrix and Cell-Cell Interaction

   1. Epithelium — Mesenchyme Interaction in the Fetal Mammary Gland

      • Klaus Kratochwil

      Pages 67-80

   2. Extracellular Matrix Effects on Mammary Cell Behavior

      • Elisa M. Durban

      Pages 81-104

   3. Extracellular Matrix: Structure, Biosynthesis, and Role in Mammary Differentiation

      • Joanne L. Blum, Mary E. Zeigler, Max S. Wicha

      Pages 105-128

   4. Adipocyte, Preadipocyte and Mammary Epithelial Cell Interaction

      • Frank E. Stockdale, Darrell Wiens

      Pages 129-140

   5. Interaction of Mammary Tumor Subpopulations

      • Fred R. Miller, Gloria H. Heppner

      Pages 141-162

4. Hormones and Growth Factors

   1. Rodent Models To ExamineIn Vivo Hormonal Regulation of Mammary Gland Tumorigenesis

      • Clifford W. Welsch

      Pages 163-179

   2. Primary Culture Systems for Mammary Biology Studies

      • Brett K. Levay-Young, Walter Imagawa, Jason Yang, James E. Richards, Raphael C. Guzman, Satyabrata Nandi

      Pages 181-203

   3. Prolactin Effects and Regulation of its Receptors in Human Mammary Tumor Cells

      • Barbara K. Vonderhaar, Ratna Biswas

      Pages 205-219

   4. Regulation of Growth and Secretion of Growth Factors by 17 B-Estradiol and V-RASH Oncogene in Human Mammary Carcinoma Cell Lines

      • Robert B. Dickson, Marc E. Lippman

      Pages 221-237

   5. Growth Factor Production by Mammary Tumor Cells

      • William R. Kidwell, S. Mohanam, David S. Salomon

      Pages 239-252

   6. Prostaglandins in Breast Cancer

      • Amy M. Fulton

      Pages 253-273

5. MMTV and Gene Expression

   1. Exogenous and Endogenous Mouse Mammary Tumor Viruses: Replication and Cell Transformation

      • Betty L. Slagle, Janel S. Butel

      Pages 275-306

   2. On the Mechanism of Carcinogenesis by Mouse Mammary Tumor Virus

      • Gordon Peters, Clive Dickson

      Pages 307-319

   3. Hormonal Control of Mouse Mammary Tumor Virus Transcription

      • N. E. Hynes, B. Groner, A. Cato, H. Ponta

      Pages 321-333

   4. Overt and Cryptic Functions of the Mouse Mammary Tumor Virus Long Terminal Repeat DNA Sequence

      • Gilbert H. Smith

      Pages 335-351

The idea for this book arose during the 1985 Gordon Conference on "Mammary Gland Biology". New developments in the methodology of cell biology and the explosive growth of molecular biology had begun to impact upon our understanding of mammary gland growth and function. It seemed a propitious time for summarizing the current status of knowledge of the cell and molecular biology of mammary cancer and for attempting to outline future areas of concern and interest. The reviews presented here were completed by the Fall of 1986. Although new insights will surely continue to emerge, it is hoped that the material in this volume will form not only a current update but a basic core of information for future experiments. We have not attempted to cover all areas of mammary gland transformation. Those areas where recent detailed reviews are already available have been omitted. Also, the areas of normal gland development, cell ultrastructure, hormone responsiveness, chemotherapy and clinical aspects of mammary cancer have not been included. Instead, we have selected those areas where the development of new methodology, reagents and results have led to new ideas about mammary gland function and development as they are related to neoplasia.

• biology
• cell
• cell biology
• development
• growth
• hormones
• molecular biology

• Baylor College of Medicine, Houston, USA

  Daniel Medina

• National Cancer Institute, Bethesda, USA

  William Kidwell, Elizabeth Anderson

• Michigan Cancer Foundation, Detroit, USA

  Gloria Heppner

Policies and ethics