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Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors

  • Book
  • © 1990

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Editors:
  1. Anil B. Mukherjee

    1. National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 279)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Phospholipases, Enzymes That Share a Substrate Class

    • Moseley Waite
    Pages 1-22

  3. Comparative Anatomy of Phospholipase A2 Structures

    • K. B. Ward, N. Pattabiraman
    Pages 23-36

  4. A Novel Bifunctional Mechanism of Surface Recognition by Phospholipase A2

    • Robert L. Heinrikson, Ferenc J. Kézdy
    Pages 37-47

  5. Activation, Aggregation, Inhibition and The Mechanism of Phospholipase A2

    • Theordore L. Hazlett, Raymond A. Deems, Edward A. Dennis
    Pages 49-64

  6. Probing the Mechanism of Pancreatic Phospholipase A2 with the Aid of Recombinant DNA Techniques

    • O. P. Kuipers, C. J. van den Bergh, H. M. Verheij, G. H. de Haas
    Pages 65-84

  7. Molecular Aspects of Phospholipase A2 Activation

    • Rodney L. Biltonen, Thomas R. Heimburg, Brian K. Lathrop, John D. Bell
    Pages 85-103

  8. Stimulation of Phospholipases A2 by Transglutaminases

    • Eleonora Cordella-Miele, Lucio Miele, Simone Beninati, Anil B. Mukherjee
    Pages 105-123

  9. Functional Consequences of Phospholipase A2 Activation in Human Monocytes

    • Thomas Hoffman, Clara Brando, Elaine F. Lizzio, Crystal Lee, Michael Hanson, Karen Ting et al.
    Pages 125-136

  10. Inhibition of Phospholipase A2 by Uteroglobin and Antiflammin Peptides

    • Lucio Miele, Eleonora Cordella-Miele, Antonio Facchiano, Anil B. Mukherjee
    Pages 137-160

  11. Antiflammins Inhibit Synthesis of Platelet-Activating Factor and Intradermal Inflammatory Reactions

    • Giovanni Camussi, Ciro Tetta, Corrado Baglioni
    Pages 161-172

  12. Isolation and Characterization of cDNA Clones from Human Placenta Coding for Phospholipase A2

    • Robert Crowl, Cheryl Stoner, Tim Stoller, Yu-Ching Pan, Robert Conroy
    Pages 173-184

  13. G Protein Regulation of Phospholipase A2: Partial Reconstitution of the System in Cells

    • Ronald M. Burch
    Pages 185-195

  14. Lipocortins as Antiphospholipase A2 and Anti-Inflammatory Proteins

    • Françoise Russo-Marie
    Pages 197-210

  15. Biology of Phospholipase Inhibitory Proteins

    • Fusao Hirata, Aiko Hirata
    Pages 211-218

  16. Inhibition Of Human Phospholipases A2 by CIS-Unsaturated Fatty Acids and Oligomers Of Prostaglandin B1

    • R. Franson, R. Raghupathi, M. Fry, J. Saal, B. Vishwanath, S. S. Ghosh et al.
    Pages 219-230

  17. Activation Of Phospholipase A2 in Rheumatoid Arthritis

    • John S. Bomalaski, Mike A. Clark
    Pages 231-238

  18. Soluble Phospholipase A2 in Human Pathology: Clinical-Laboratory Interface

    • W. Pruzanski, P. Vadas
    Pages 239-251

  19. Back Matter

    Pages 253-264
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Keywords

About this book

During the past decade there has been a dramatic expansion of our knowledge on phospholipases in general, and phospholipase A2 (PLA2) in particular. Progress in this field has been evident on many fronts, with novel information rapidly accumulating in the literature regarding the chemistry and molecular biology of this enzyme and its role in many important physiological processes. These include cellular signal transduction via the G-protein cycle, and in the generation of many cellular mediators, such as the platelet activating factor (PAF) and the eicosanoids that participate in the initiation and propagation of inflammation, to mention a few. This symposium was organized to obtain an overview of current investigations on this enzyme from the standpoint of its chemistry, molecular biology and physiology. Another important focus of this symposium concerns the regulation of PLA2, including endogenous and synthetic inhibitors and activators of this enzyme. To review these important areas in PLA2 research we invited scientists who made significant contributions in this field. The papers in this volume are organized to emphasize the recent advances in several areas of investigation, including: (I) the structure and mechanism of action of PLA2, (2) mechanism of activation of PLA2, (3) molecular biology, physiology and endogenous inhibitors of this enzyme and finally, (4) clinical investigations emphasizing the pathophysiological role of this enzyme in human diseases. The first article in this volume is by Dr.

Editors and Affiliations

  • National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, USA

    Anil B. Mukherjee

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