Antioxidant Nutrients and Immune Functions

1. Front Matter

   Pages i-xi

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2. Antioxidant Nutrients and Immune Functions - Introduction

   • Adrianne Bendich

   Pages 1-12

3. Cellular and Molecular Basis of Nutrition-Immunity Interactions

   • Ranjit Kumar Chandra

   Pages 13-18

4. The Role of Antioxidants in Modulating Neutrophil Functional Responses

   • Laurence A. Boxer

   Pages 19-33

5. Antioxidant Vitamins and Their Functions in Immune Responses

   • Adrianne Bendich

   Pages 35-55

6. Antioxidants and the Aging Immune Response

   • Simin Nikbin Meydani, Mohsen Meydani, Jeffrey B. Blumberg

   Pages 57-67

7. Anti-Inflammatory Systems in Human Milk

   • Armond S. Goldman, Randall M. Goldblum, Lars Å. Hanson

   Pages 69-76

8. The Administration of Beta Carotene to Prevent and Regress Oral Carcinoma in the Hamster Cheek Pouch and the Associated Enhancement of the Immune Response

   • Joel L. Schwartz, Gerald Shklar, Evelyn Flynn, Diane Trickler

   Pages 77-93

9. Studies on Membrane Lipid Peroxidation in Omega-3 Fatty Acid-Fed Autoimmune Mice: Effect of Vitamin E Supplementation

   • Serge Laganiere, Byung P. Yu, Gabriel Fernandes

   Pages 95-102

10. Immunity and Disease Resistance in Farm Animals Fed Vitamin E Supplement

    • Robert P. Tengerdy

    Pages 103-110

11. Possible Roles for Zinc in Destruction of Trypanosoma Cruzi by Toxic Oxygen Metabolites Produced by Mononuclear Phagocytes

    • J. M. Cook-Mills, J. J. Wirth, P. J. Fraker

    Pages 111-121

12. Effects of Copper Deficiency on the Immune System

    • Joseph R. Prohaska, Omelan A. Lukasewycz

    Pages 123-143

13. Selenium and Glutathione Peroxidase: Essential Nutrient and Antioxidant Component of the Immune System

    • Julian E. Spallholz

    Pages 145-158

14. Epilogue

    • Robert P. Tengerdy

    Pages 159-161

15. Back Matter

    Pages 163-171

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The detenmnation of optimal nutritional status has traditionally been based upon generalized parameters such as weight gain and body fat levels. Vitamin and mineral requirements were often related to the intakes needed to prevent overt signs of deficiency diseases such as beriberi or scurvy. However, in the past decade or so, there have been intensive investigations to determine the subtle changes in physiological functions associated with marginal micronutrient intakes. There is a growing consensus that immune system activities are very sensitive indicators of micronutrient status. During this decade, there has also been a rapid expansion of research in the role of free radicals and antioxidants in the major chronic diseases which afflict mankind( i.e. cancer, cardiovascular disease,and autoimmune disease). The main function of antioxidant nutrients in an appropriate diet is the prevention of oxidative damage to cells and their physiological functions. Antioxidant nutrients counteract free radicals and damaging oxidative actions on cell membranes. Since the cells of the immune system are rapidly differentiating and proliferating, such dividing and transforming cells are particularly susceptible to damage by oxidation. The interactions of antioxidant nutrition and immune system activities and disease resistance are therefore logical areas for research. Thus, the objective of this symposium was to bring together the leading investigators who have examined the immunological effects of dietary essential nutrients which share the capacity to act as antioxidants.

• Oxidation
• Vitamin
• antioxidant
• cancer
• cell membrane
• fat
• nutrition
• prevention

• Hoffmann LaRoche, Inc., Nutley, USA

  Adrianne Bendich

• Agricultural Research Service, USDA, NADC, Ames, USA

  Marshall Phillips

• Colorado State University, Fort Collins, USA

  Robert P. Tengerdy

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