Application of Basic Neuroscience to Child Psychiatry

1. Front Matter

   Pages i-xx

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2. Introduction

   1. Introduction

      • Stephen I. Deutsch, Abraham Weizman, Ronit Weizman

      Pages 1-5

3. Basic Neuroscience Considerations

   1. Front Matter

      Pages 7-7

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   2. Molecular Neurobiology and Disorders of Brain Development

      • Roland D. Ciaranello, Dona Lee Wong, John L. R. Rubenstein

      Pages 9-32

   3. Neurotransmitter Assessment in Neuropsychiatric Disorders of Childhood

      • Ann M. Rasmusson, Mark A. Riddle, James F. Leckman, George M. Anderson, Donald J. Cohen

      Pages 33-59

   4. Role of the GABA—Benzodiazepine Receptor Complex in Stress

      • Stephen I. Deutsch, Abraham Weizman, Ronit Weizman, Frank J. Vocci Jr., Karin A. Kook

      Pages 61-76

   5. Brain Recognition Sites for Methylphenidate and the Amphetamines

      • Richard L. Hauger, Itzchak Angel, Aaron Janowsky, Paul Berger, Bridget Hulihan-Giblin

      Pages 77-100

   6. Neuropeptide Modulation of Development and Behavior

      • Curt A. Sandman, Abba J. Kastin

      Pages 101-124

   7. Drug Discrimination Studies in Animals

      • John Mastropaolo, Anthony L. Riley

      Pages 125-140

   8. The Platelet as a Peripheral Model of Serotonergic Function in Child Psychiatry

      • Moshe Rehavi, Ronit Weizman

      Pages 141-151

   9. Neuroendocrine Abnormalities in Autism and Schizophrenic Disorder of Childhood

      • Ronit Weizman, Lynn H. Deutsch, Stephen I. Deutsch

      Pages 153-160

   10. Autoimmune Dysfunction in Neurodevelopmental Disorders of Childhood

       • Abraham Weizman, Frank J. Vocci Jr.

       Pages 161-164

   11. Nonketotic Hyperglycinemia

       • Stephen I. Deutsch, Lynn H. Deutsch, Ronit Weizman

       Pages 165-180

4. Application to Specific Clinical Disorders

   1. Front Matter

      Pages 181-181

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   2. Genetic Causes of Autism and the Pervasive Developmental Disorders

      • J. Gerald Young, James R. Brasic, Len Leven

      Pages 183-216

   3. Biological Studies of Schizophrenia with Childhood Onset

      • Wayne H. Green, Stephen I. Deutsch

      Pages 217-229

   4. Biological Studies of Attention-Deficit Disorder

      • Ronit Weizman, Abraham Weizman, Stephen I. Deutsch

      Pages 231-239

   5. Biochemical and Genetic Studies of Tourette’s Syndrome

      • Phillip B. Chappell, James F. Leckman, David Pauls, Donald J. Cohen

      Pages 241-260

   6. Obsessive-Compulsive Disorder

      • Elizabeth V. Koby

      Pages 261-274

   7. Neurochemical and Neuroendocrine Considerations of Obsessive-Compulsive Disorders in Childhood

      • Susan E. Swedo, Judith L. Rapoport

      Pages 275-284

The idea for this book developed during the course of several discussions among the editors while we were working together as staff scientists in the laboratories of the Clinical Neuro­ science Branch of the National Institute of Mental Health. It was a happy coincidence that the three of us, child psychiatrists with predominantly clinical interests, selected a collaborative bench research project involving neurotransmitter receptor characterization and regulation. We appreciated the relevance of our work to child psychiatry and wished for a forum to share the excitement we enjoyed in the laboratory with our clinical colleagues. Moreover, it seemed to us that much of the pharmacological research in child psychiatry proceeded on an empirical basis, often without a compelling neurochemical rationale. This could reflect the paucity of neurochemical data that exists in child psychiatry and the very limited understanding of the pathophysiology in most psychiatric disorders that occur in childhood. Also, we bemoaned the fact that there was a virtual absence of meaningful interchange between clinical investigators in child psychiatry and their colleagues in the neurosciences. We believed that an edited book appealing to clinicians and basic scientists could serve as an initial effort to foster interchange between them. The editors wish to emphasize that this book is viewed as only a beginning in the process of interchange that must take place.

• Assessment
• Depression
• Intervention
• Methylphenidat
• Nervous System
• Neuroscience
• Syndrom
• attention
• genetics
• neuropsychology
• psychiatry
• maternal and child health

• Veterans Administration Medical Center, USA

  Stephen I. Deutsch

• Georgetown University School of Medicine, USA

  Stephen I. Deutsch

• Tel Aviv University, Tel Aviv, Israel

  Abraham Weizman, Ronit Weizman

Policies and ethics