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Myocardial Protection and the KATP Channel

  • Book
  • © 1995

Overview

Editors:
  1. Derek M. Yellon

    1. University College London Medical School & Hospitals, London, UK

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    You can also search for this editor in PubMed   Google Scholar

  2. Garrett J. Gross

    1. Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 179)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-ix
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  2. The Biology of KATP Channels

    • Nicholas B. Standen
    Pages 1-30

  3. Vascular Pathology and The KATP Channel

    • Ulrich Quast, Stefan Glocker
    Pages 31-50

  4. Activation of ATP-Sensitive Potassium Channels: A Novel Pharmacological Approach to Myocardial Protection?

    • David J. Hearse
    Pages 51-98

  5. The Relationship between The KATP Channel and Myocardial Preconditioning

    • Garret J. Gross, Derek M. Yellon
    Pages 99-120

  6. Potassium Channel Activation and Arrhythmogenicity

    • Michiel J. Janse, Arthur A. M. Wilde
    Pages 121-139

  7. Clinical Exploitation of the KATP Channel

    • Henry Purcell, Kim Fox
    Pages 141-159

  8. Is There a Potential Role for KATP Openers in the Treatment of Angina?

    • Lionel H. Opie
    Pages 161-177

  9. KATP Channel Exploitation for Treating Myocardial Ischemia-Future Directions

    • Gary J. Grover
    Pages 179-207

  10. Back Matter

    Pages 209-214
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Keywords

About this book

The ATP-sensitive potassium channel (KATP) was discovered in 1983. Since then, an enormous amount of research has been undertaken to characterize it in detail. This volume consolidates both the current knowledge and most recent advances on the subject, and its relationship to myocardial protection. To this end, the editors have assembled investigators at the forefront of ongoing basic and clinical research to provide scholarly and candid comments concerning each of the pertinent issues, including: a comprehensive review of the biology of the channel with respect to the structure-activity relationship as well as overall chemistry of the channel; the role of opening this channel and its effect on smooth muscle (covering both the effects on myocardial stunning and its ability to protect against myocardial infarction); the relationship of KATP channel opening and the protection to the myocardium afforded by the phenomenon of ischemic preconditioning; the relationship between the KATP channel and electrophysiological consequences with specific reference to arrhythmogenicity; and the clinical implications of the use of agents that mimic the opening of this channel, with reference to its protective nature and its use in the treatment of angina.
Audience: Clinicians and basic scientists who have a direct interest in the KATP channel as well as those groups who are interested in the entire concept of myocardial protection and its relationship to academic and clinical medicine.

Editors and Affiliations

  • University College London Medical School & Hospitals, London, UK

    Derek M. Yellon

  • Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, USA

    Garrett J. Gross

Bibliographic Information

  • Book Title: Myocardial Protection and the KATP Channel

  • Editors: Derek M. Yellon, Garrett J. Gross

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-1-4613-0453-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1995

  • Hardcover ISBN: 978-0-7923-3791-1Published: 31 December 1995

  • Softcover ISBN: 978-1-4613-8055-9Published: 27 September 2011

  • eBook ISBN: 978-1-4613-0453-1Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: X, 214

  • Topics: Cardiology

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