Molecular, Cellular, and Clinical Aspects of Angiogenesis

1. Front Matter

   Pages i-ix

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2. Heterogeneity of Endothelial Cells

   1. On the Possible Role of Endothelial Cell Heterogeneity in Angiogenesis

      • Peter I. Lelkes, Vangelis G. Manolopoulos, Matthew Silverman, Shaosong Zhang, Soverin Karmiol, Brian R. Unsworth

      Pages 1-17

   2. Gene Expression and Endothelial Cell Differentiation

      • D. S. Grant, J. L. Kinsella, H. K. Kleinman

      Pages 19-29

3. Role of Extracellular Matrix in Angiogenesis

   1. Co-Expression of the α2-Subunit of Laminin and the Metastatic Phenotype in Melanoma Cells

      • Jing Han, Nicholas A. Kefalides

      Pages 31-36

   2. Plasminogen Activators in Fibrinolysis and Pericellular Proteolysis. Studies on Human Endothelial Cells in Vitro

      • Victor W. M. van Hinsbergh, Pieter Koolwijk, Roeland Hanemaaijer

      Pages 37-49

   3. The Effect of Ionizing Radiation on Endothelial Cell Differentiation and Angiogenesis

      • S. K. Williamson, R. W. Rose, M. O’Hara, D. S. Grant

      Pages 51-60

4. Angiogenic Factors and Their Receptors

   1. Basic Fibroblast Growth Factor Expression in Endothelial Cells: An Autocrine Role in Angiogenesis?

      • Anna Gualandris, Marco Rusnati, Patrizia Dell’Era, Daniela Coltrini, Elena Tanghetti, Emanuele Nelli et al.

      Pages 61-72

   2. The Biology of Vascular Endothelial Growth Factor

      • Napoleone Ferrara

      Pages 73-83

   3. Scatter Factor As a Potential Tumor Angiogenesis Factor

      • Eliot M. Rosen, Itzhak D. Goldberg

      Pages 85-94

   4. The Role of Thrombin in Angiogenesis

      • Michael E. Maragoudakis

      Pages 95-103

   5. The Role of Thrombospondin in Angiogenesis

      • Luisa A. DiPietro, Peter J. Polverini

      Pages 105-113

   6. Signal Transduction Pathways and the Regulation of Angiogenesis

      • Michael E. Maragoudakis

      Pages 115-123

5. Physiological Angiogenesis

   1. Angiogenesis in the Female Reproductive Organs

      • Lawrence P. Reynolds, Dale A. Redmer, Anna T. Grazul-Bilska, S. Derek Killilea, R. M. Moor

      Pages 125-139

   2. Angiogenesis in Skeletal Muscle

      • O. Hudlicka, M. D. Brown, S. Egginton

      Pages 141-150

   3. Wound Healing Angiogenesis: The Metabolic Basis of Repair

      • James S. Constant, David Y. Suh, M. Zamirul Hussain, Thomas K. Hunt

      Pages 151-159

   4. Wound Healing, Fibrin and Angiogenesis

      • W. Douglas Thompson, Stephen J. McNally, Naren Ganesalingam, Deirdre S. E. McCallion, Christina M. Stirk, William T. Melvin

      Pages 161-172

6. Pathological Angiogenesis

   1. Tumor Oxygenation and Tumor Vascularity: Evidence for Their Clinical Relevance in Cancer of the Uterine Cervix and Considerations on Their Potential Biological Role in Tumor Progression

      • Michael Höckel, Karlheinz Schienger, Margarete Mitze

      Pages 173-179

   2. Role of Scatter Factor in Pathogenesis of Aids-Related Kaposi Sarcoma

      • Eliot M. Rosen, Peter J. Polverini, Brian J. Nickoloff, Itzhak D. Goldberg

      Pages 181-189

   3. Role of the Early Response Gene Cyclooxygenase (Cox)-2 in Angiogenesis

      • Timothy Hla, Ari Ristimäki, Kirsi Narko, Pazit Ben-Av, Menq-Jer Lee, Mark Evans et al.

      Pages 191-198

7. Inhibitors of Angiogenesis

   1. A Heparanase-Inhibitory, bFGF-Binding Sulfated Oligosaccharide that Inhibits Angiogenesis Ex Ovo has Potent Antitumor and Antimetastatic Activity in Vivo

      • Robert J. Tressler, J. Wee, N. Storm, P. Fugedi, C. Peto, R. J. Stack et al.

      Pages 199-211

There has been an explosion of research activity related to angiogenesis in recent years, and hundreds of laboratories worldwide are actively involved in many aspects of angiogenesiS. The literature on angiogenesis increases exponentially every year, and more than 16,000 peer-reviewed articles have been published the past 25 years, which are scattered in basic science and clinical journals. The complexity of the cascade of events leading to new vessel formation from preexisting ones has challenged scientists in cell biology, biochemistry, physiology, pharmacology, molecular biology, developmental biology, and other fields. With their multidisciplinary approach and the powerful new techniques that have been developed, the progress in understanding angiogenesis has been impressive indeed. Only 12 years ago the mention of an angiogenic factor caused skepticism. Today we have the complete amino-acid fiequence and their genes cloned for at least 9 angiogenic factors. Many laboratories are studying their role in angiogenesis, and several biotechnology firms have a keen interest in commercial developments relative to these molecules. The role of extracellular matrix components in angiogenesis and the interaction of endothelial cells with other cell types such as pericytes, smooth muscle cells, and inflammatory cells have been studied by other groups. This rapid expansion is the result of a realization that in many disease states a common underlying pathology is a derangement in angiogenesis.

• Oligosaccharid
• biochemistry
• biology
• biotechnology
• cancer
• cell biology
• development
• developmental biology
• growth
• molecular biology
• pharmacology
• physiology
• receptor
• research

• University of Patras Medical School, Patras, Greece

  Michael E. Maragoudakis

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