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Natural Toxins 2

Structure, Mechanism of Action, and Detection

  • Book
  • © 1996

Overview

Editors:
  1. Bal Ram Singh

    1. University of Massachusetts, Dartmouth, North Dartmouth, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Anthony T. Tu

    1. Colorado State University, Fort Collins, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 391)

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Table of contents (43 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Overview of Toxins

    1. Marine Natural Products

      • Paul J. Scheuer
      Pages 1-8

    2. Plant Toxins

      • Gary D. Manners
      Pages 9-35

    3. Overview of Snake Venom Chemistry

      • Anthony T. Tu
      Pages 37-62

    4. Critical Aspects of Bacterial Protein Toxins

      • Bal Ram Singh
      Pages 63-84

  3. Origin, Stucture and Function

    1. Structure and Function of Cobra Neurotoxin

      • C. C. Yang
      Pages 85-96

    2. Structure and Function of Cobra Venom Factor, the Complement-Activating Protein in Cobra Venom

      • Carl-Wilhelm Vogel, Reinhard Bredehorst, David C. Fritzinger, Thomas Grunwald, Patrick Ziegelmüller, Michael A. Kock
      Pages 97-114

    3. A CASE STUDY OF CARDIOTOXIN III FROM THE TAIWAN COBRA (Naja naja atra) Solution Structure and Other Physical Properties

      • T. K. S. Kumar, C.-S. Lee, C. Yu
      Pages 115-129

    4. The Staphylococcal and Streptococcal Pyrogenic Toxin Family

      • Gregory A. Bohach, Cynthia V. Stauffacher, Douglas H. Ohlendorf, Young-In Chi, Gregory M. Vath, Patrick M. Schlievert
      Pages 131-154

    5. PRIMARY STRUCTURAL MOTIFS OFConus PEPTIDES

      • Lourdes J. Cruz
      Pages 155-167

    6. Hymenoptera Venom Proteins

      • Donald R. Hoffman
      Pages 169-186

    7. Structure and Functions of Coagulation Factor IX/Factor X-Binding Protein Isolated from the Venom of Trimeresurus flavoviridis

      • Takashi Morita, Hideko Atoda, Fujio Sekiya
      Pages 187-196

    8. Structure and Function Relationship of Crotoxin, a Heterodimeric Neurotoxic Phospholipase A2 from the Venom of a South-American Rattlesnake

      • V. Choumet, C. Bouchier, E. Délot, G. Faure, B. Saliou, C. Bon
      Pages 197-202

    9. Atroxase—A Fibrinolytic Enzyme Isolated from the Venuom of Western Diamond Back RattleSnake

      • Brenda J. Baker, Anthony T. Tu
      Pages 203-211

    10. Isolation of a Novel Lectin from the Globiferous Pedicellariae of the Sea Urchin Toxopneustes Pileolus

      • H. Nakagawa, H. Hashimoto, H. Hayashi, M. Shinohara, K. Ohura, E. Tachikawa et al.
      Pages 213-223

    11. Indian Catfish (Plotosus canius, Hamilton) Venom

      • B. Auddy, A. Gomes
      Pages 225-229

    12. Neurotoxin from Black Widow Spider Venom Structure and Function

      • E. V. Grishin
      Pages 231-236

    13. Structural and Fuctional Studies of Latrodectin from the Venom of Black Widow Spider (Latrodectus tredecimguttatus)

      • A. Grasso, M. Pescatori
      Pages 237-243

    14. Effects of Toxic Shock Syndrome Toxin-1 and a Site-Directed Mutant, H135A, in Mice

      • B. G. Stiles, T. Krakauer, P. F. Bonventre
      Pages 245-250

    15. The Relationship between Histidine Redidues and Various Biological Activities of Clostridium perfringens Alpha Toxin

      • Masahiro Nagahama, Sadayuki Ochi, Keiko Kobayashi, Jun Sakurai
      Pages 251-255
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Keywords

About this book

From beach encounters, aquaculture perils, and processed-food poisoning to snake bites and biological warfare, natural toxins seem never to be far from the public's sight. A better understanding of toxins in terms of their origin, structure, structure-function relation­ ships, mechanism of action, and detection and diagnosis is of utmost importance to human and animal food safety, nutrition, and health. In addition, it is now clear that many of the toxins can be used as scientific tools to explore the molecular mechanism of several biological processes, be it a mechanism involved in the function of membrane channels, exocytosis, or cytotoxicity. Several of the natural toxins have also been approved as therapeutic drugs, which has made them of interest to several pharmaceutical companies. For example, botulinum neurotoxins, which have been used in studies in the field of neurobiology, have also been used directly as therapeutic drugs against several neuromus­ cular diseases, such as strabismus and blepherospasm. Toxins in combination with modem biotechnological approaches are also being investigated for their potential use against certain deadly medical problems. For example, a combination of plant toxin ricin and antibodies is being developed for the treatment of tumors. The great potential of natural toxins has attracted scientists of varying backgrounds-pure chemists to cancer biologists-to the study of fundamental aspects of the actions of these toxins.

Editors and Affiliations

  • University of Massachusetts, Dartmouth, North Dartmouth, USA

    Bal Ram Singh

  • Colorado State University, Fort Collins, USA

    Anthony T. Tu

Bibliographic Information

  • Book Title: Natural Toxins 2

  • Book Subtitle: Structure, Mechanism of Action, and Detection

  • Editors: Bal Ram Singh, Anthony T. Tu

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4613-0361-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1996

  • Softcover ISBN: 978-1-4613-8016-0Published: 26 September 2011

  • eBook ISBN: 978-1-4613-0361-9Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: 548

  • Topics: Biochemistry, general, Pharmacy, Waste Management/Waste Technology, Ecotoxicology

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