Intracellular Protein Catabolism

1. Front Matter

   Pages i-xiii

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2. The Metzincin-Superfamily of Zinc-Peptidases

   • W. Bode, F. Grams, P. Reinemer, F.-X. Gomis-Rüth, U. Baumann, D. B. McKay et al.

   Pages 1-11

3. Structure and Biosynthesis of Meprins

   • P. Marchand, J. S. Bond

   Pages 13-22

4. Involvement of Tissue Inhibitors of Metalloproteinases (TIMPS) During Matrix Metalloproteinase Activation

   • H. Nagase, K. Suzuki, Y. Itoh, C.-C. Kan, M. R. Gehring, W. Huang et al.

   Pages 23-31

5. Structure and Function of a Novel Arginine-Specific Cysteine Proteinase (Argingipain) as a Major Periodontal Pathogenic Factor From Porphyromonas Gingivalis

   • Kenji Yamamoto, Tomoko Kadowaki, Kuniaki Okamoto, Masahiro Yoneda, Koji Nakayama, Yoshio Misumi et al.

   Pages 33-42

6. Discovery of a New Type of Proteinase Inhibitor Family Whose Members Have an Anchoring Sequence

   • S. Hirose, M. Furukawa, I. Tamechika, M. Itakura, A. Kato, Y. Suzuki et al.

   Pages 43-49

7. Proposed Role of a γ-Interferon Inducible Proteasome-Regulator in Antigen Presentation

   • C. A. Realini, M. C. Rechsteiner

   Pages 51-61

8. Novel Members of Mammalian Kexin Family Proteases, Pace 4C, Pace 4D, PC 7A and PC 7B

   • Y. Matsuda, A. Tsuji, H. Nagamume, T. Akamatsu, C. Hine, K. Muramatsu et al.

   Pages 63-71

9. Phytocystatins and Their Target Enzymes-Molecular Cloning, Expression and Possible Functions

   • S. Arai, K. Abe, Y. Emori

   Pages 73-78

10. Horseshoe Crab Factor G: A New Heterodimeric Serine Protease Zymogen Sensitive to (1→3)-β-D-Glucan

    • Tatsushi Muta, Noriaki Seki, Yoshie Takaki, Ryuji Hashimoto, Toshio Oda, Atsufumi Iwanaga et al.

    Pages 79-85

11. The 43 kDa Papain-Inhibiting Protein in Psoriatic Epidermis is Identical to Squamous Cell Carcinoma Antigen (SCC-Antigen)

    • M. Järvinen, N. Kalkkinen, A. Rinne, V. K. Hopsu-Havu

    Pages 87-93

12. Alpha-Mercaptoacrylic Acid Derivatives as Novel Selective Calpain Inhibitors

    • Kevin K. W. Wang, Avigail Posner, Kadee J. Raser, Michelle Buroker-Kilgore, Rathna Nath, Iradj Hajimohammadreza et al.

    Pages 95-102

13. Structural Aspects of Autophagy

    • Per O. Seglen, Trond Olav Berg, Henrietta Blankson, Monica Fengsrud, Ingunn Holen, Per Eivind Strømhaug

    Pages 103-111

14. Mechanism of Autophagy in Permeabilized Hepatocytes

    • Motoni Kadowaki, Rina Venerando, Giovanni Miotto, Glenn E. Mortimore

    Pages 113-119

15. Lysosomal Proteinosis Based on Decreased Degration of a Specific Protein, Mitochondrial ATP Synthase Subunit C

    • J. Ezaki, L. S. Wolfe, K. Ishidoh, D. Muno, T. Ueno, E. Kominami

    Pages 121-128

16. The Neuronal Ceroid Lipofuscinoses (Batten Disease)

    • D. N. Palmer, J. M. Hay

    Pages 129-136

17. Energy-Dependent Degration of a Mutant Serine:Pyruvate/Alanin: Glyoxylate Aminotransferase in a Primary Hyperoxaluria Type 1 C

    • Toshiaki Suzuki, Kozo Nishiyama, Tsuneyoshi Funai, Keiji Tanaka, Akira Ichihara, Arata Ichiyama

    Pages 137-140

18. Endopeptidase-24.11 (Neprilysin) and Relatives

    • A. J. Turner, L. J. Murphy, M. S. Medeiros, K. Barnes

    Pages 141-148

19. Function of Calpains

    • M. Hayashi, M. Inomata, S. Kawashima

    Pages 149-154

20. Cleavage of the Human C5A Receptor by Protienases Derived from Porphyromonas Gingivalis

    • Mark A. Jagels, Julia A. Ember, James Travis, Jan Potempa, Robert Pike, Tony E. Hugli

    Pages 155-164

The Tenth International Conference on Intracellular Protein Catabolism was held in Tokyo Japan, October 30-November 3, 1994. under the auspices of the International Committee on Proteolysis (lCOP). ICOP meetings have been held biennially in the USA, Europe, and Japan in turn. The previous three ICOP meetings (7th to 9th) were held in Shimoda, Japan, in 1988. in WildbadKreuth, Germany, in 1990, and in Williamsburg. Virginia, in 1992. Previous meetings were held in resort areas, this was the first meeting held in a large city. Attendance has grown every year so that nearly 400 participants from 19 different countries attended the Tokyo meeting. At the meeting, novel and updated results on the structure-function. physiology, biology, and pathology of proteases and inhibitors were discussed, together with cellular aspects of proteolysis and protein turnover. Thirty-nine invited papers and eight selected posters were presented orally and 171 poster presentations were discussed. This book documents almost all of the lectures and some selected posters. Since the world of proteolysis and protein turnover is expanding very rapidly. far beyond our expectations, it is impossible to cover all the new aspects of this field. However, this book will give an idea of the current status, trends. and directions of the field, and information necessary to understand what is and will be important in this field. Further. the editors hope that the novel ideas, approaches. methodologies, and important findings described in this book will stimulate further study on proteolysis and protein turnover.

• ATP
• HIV
• biology
• gene
• immunodeficiency
• mitochondria
• molecular aspects
• mutation
• physiology
• protein
• synthesis
• tissue

• University of Tokyo, Tokyo, Japan

  Koichi Suzuki

• College of Medicine, Penn State University, Hershey, USA

  Judith S. Bond

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