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Biology of Endothelial Cells

  • Book
  • © 1984

Overview

Editors:
  1. Eric A. Jaffe

    1. Department of Medicine, Division of Hematology-Oncology, Cornell University Medical College, USA

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Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 27)

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Table of contents (44 chapters)

  1. Front Matter

    Pages I-XV
    Download chapter PDF

  2. Tissue Culture of Endothelial Cells

    1. Culture and identification of large vessel endothelial cells

      • Eric A. Jaffe
      Pages 1-13

    2. Culture of capillary endothelial cells

      • Bruce R. Zetter
      Pages 14-26

    3. Culture of endothelial cells from neural capillaries

      • Phillip D. Bowman, A. Lorris Betz, Gary W. Goldstein
      Pages 27-33

    4. Culture of pulmonary endothelial cells on microcarrier beads

      • Una S. Ryan
      Pages 34-50

    5. Construction of an artificial blood vessel wall from cultured endothelial cells

      • Robert F. Taylor
      Pages 51-58

  3. Determinants of Endothelial and Smooth Muscle Cell Growth

    1. Growth requirements for bovine aortic endothelium in vitro

      • Corinne M. Gajdusek, Stephen M. Schwartz
      Pages 59-65

    2. Contact inhibition in the endothelium

      • Stephen M. Schwartz, Corinne M. Gajdusek
      Pages 66-73

    3. Endothelial cell motility

      • Christian C. Haudenschild, Sandra Harris-Hooker
      Pages 74-86

    4. Factors which stimulate the growth of human umbilical vein endothelial cells in vitro

      • T. Maciag, G. A. Hoover, M. B. Stemerman, R. Weinstein
      Pages 87-96

    5. Macrophages, neovascularization, and the growth of vascular cells

      • Michael A. Gimbrone Jr.
      Pages 97-107

    6. The limited life-span of bovine endothelial cells

      • Elliot M. Levine, Stephen N. Mueller, Judith B. Grinspan, James P. Noveral, Eliot M. Rosen
      Pages 108-117

    7. Endothelium, heparin, and the regulation of vascular smooth muscle cell growth

      • John J. Castellot Jr., Robert D. Rosenberg, Morris J. Karnovsky
      Pages 118-128

  4. Morphology of Cultured Endothelial Cells

    1. Morphology of vascular endothelial cells in culture

      • Christian C. Haudenschild
      Pages 129-140

    2. The endothelial cytoskeleton

      • Stephen H. Blose
      Pages 141-154

  5. Synthesis of Connective Tissue Elements by Endothelial Cells

    1. Metabolism of thrombospondin and fibronectin by endothelial cells

      • Deane F. Mosher, Eliot C. Williams, Paula J. McKeown-Longo
      Pages 155-160

    2. Collagen synthesis by endothelial cells in culture

      • Helene Sage
      Pages 161-177

    3. Sulfated glycosaminoglycans and vascular endothelial cells

      • P. Christer Busch
      Pages 178-188

    4. Elastin synthesis by endothelial cells

      • Jerome O. Cantor, Mary S. Parshley, Ines Mandl, Gerard M. Turino
      Pages 189-193

    5. Gene mapping using hybrids of human endothelial cells and rodent fibroblasts

      • Nicholas A. Kefalides
      Pages 194-199
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Keywords

About this book

The participation of endothelial cells in various physiologic and pathologic processes has been hypothesized since before the turn of the century. However, until recently, direct evidence for endothelial involvement in these processes has been extremely difficult to obtain due to the inability to study endothelial cell function in vitro. Though the possibility of using cultured endothelial cells to study endothelial cell function in vitro was recognized many years ago, the inability to culture unambiguously identifiable endothelial cells limited investigators in their studies of endothelial function. As a result, the field of endothelial cell biology lay relatively fallow for many years. The development in the early 1970's of routine and easily implemented methods for culturing human endothelial cells and the demonstration that cultured endothelial cells synthesized a physiologically relevant protein, Factor VIII/von Willebrand Factor, quickly changed this state of affairs. Over the following decade the scope of endothelial cell research rapidly widened, spreading in a number of directions. First, methods were developed to culture endothelial cells from a variety of species. Second, methods were developed to culture endothelial cells from different organs and types of blood vessels (arteries, veins, and capillaries) within a single species. Third, and most important, investigators began using cultured endothelial cells as tools to study the potential involvement of endothelial cells in a wide assortment of biologically interesting processes. The net result has been a tremendous increase in our understanding of endothelial cell function.

Editors and Affiliations

  • Department of Medicine, Division of Hematology-Oncology, Cornell University Medical College, USA

    Eric A. Jaffe

Bibliographic Information

  • Book Title: Biology of Endothelial Cells

  • Editors: Eric A. Jaffe

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-1-4613-2825-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishers, Boston 1984

  • eBook ISBN: 978-1-4613-2825-4Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: 460

  • Number of Illustrations: 144 b/w illustrations, 1 illustrations in colour

  • Topics: Cardiology

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