Pathobiology of Cardiovascular Injury

1. Front Matter

   Pages i-xvi

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2. Neural Components in Control of Cardiac Structure/Function

   1. Front Matter

      Pages 1-1

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   2. Myofilament Protein Phosphorylation and Neural Regulation of Cardiac Contractility

      • R. J. Solaro, J. L. Garvey

      Pages 3-13

   3. The Effects of Chronic Infusion of Norepinephrine on Cardiac Structure, Function and Biochemistry — Physiological vs. Pathological Hypertrophy

      • M. M. Laks

      Pages 14-30

   4. Load Regulation of Cardiac Muscle

      • G. Cooper

      Pages 31-47

   5. Cardiocardiac Reflexes — The Role of the Spinoreticular Tract

      • R. D. Foreman

      Pages 48-59

3. Electrophysiology and Arrhythmias

   1. Front Matter

      Pages 61-61

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   2. The Ionic Currents Underlying Pacemaker Activity

      • Dario DiFrancesco

      Pages 63-83

   3. Cytosolic Sodium Ion Activity in Heart Cells

      • H. A. Fozzard

      Pages 84-97

   4. The Basis of Triggered Activity

      • M. R. Rosen, J. P. Moak, B. P. Damiano

      Pages 98-105

4. Myocyte Models of Ischemia

   1. Front Matter

      Pages 107-107

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   2. Regulation of Calcium Slow Channel Function by Metabolism and Cyclic Nucleotides

      • N. Sperelakis, G. Bkaily

      Pages 109-144

   3. Cultured Heart Cells as a Model for Studying Myocardial Ischemia

      • M. Lieberman, A. Lefurgey, E. Murphy, S. Liu

      Pages 145-155

   4. Membrane Potential of Neonatal Rat Myocytes: A Microelectrode and Patch Clamp Study

      • O. F. Schanne, M. Le Floch, R. Sauvé, M. D. Payet

      Pages 156-163

   5. Metabolic Changes in Isolated Myocytes Following Hypoxia

      • K. H. McDonough, R. E. Shepherd, J. J. Spitzer

      Pages 164-174

5. Ionic and Metabolic Response of the Heart to Ischemia

   1. Front Matter

      Pages 175-175

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   2. Ionic and Metabolic Responses of the Heart to Ischemia

      • G. A. Langer

      Pages 177-179

   3. Alterations of Ionic Permeability during Ischemia

      • K. I. Shine, J. Weiss, M. Bersohn

      Pages 180-189

   4. Carbohydrate and Lipid Metabolism in Ischemia

      • A. J. Liedtke, J. E. Orie, E. J. Toggart

      Pages 190-201

6. Sarcolemma Structure and Function

   1. Front Matter

      Pages 203-203

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This volume represents a part of the scientific proceedings of the Sixth Annual Meeting of the American Section of the International Society for Heart Research that was held in Oklahoma City from September 13-15, 1984. The chapters have been grouped according to the content of invited symposia on cardiovascular topics ranging from electrophysiology, autonomic control of the circulation, aging of the myocardium, mechanisms of cardiovascular injury, cultured heart cell studies, etc. Abstracts of all the papers presented at this meeting are included in Volume 16 (Supp. 1) of the Journal of Molecular and Cellular Cardiology. Since our understanding of the pathobiology of cardiovascular injury requires integrating knowledge from both basic and clinical sciences, the information presented in this volume extends from fundamental biochemical processes to pharmacological agents required to treat complex cardiac arrhythmias. At the molecular level, the structural lipids of the sarcolemma may be altered during myocardial ischemia; the role of free radicals in this process is one emerging area of active study. At the subcellular level, plasma membranes provide the anatomical basis for maintenance of optimal potentials of excitable cells; the anatomy and physiology of the sarcolemma ultimately determines the response to drugs and metabolic perturbants. At the cellular level, much progress has been made in our understanding of cultured and adult myocytes during ischemia and hypoxia; in particular, the electrophysiology of these model systems is well understood and several chapters address this approach.

• anatomy
• cardiovascular
• cardiovascular function
• circulation
• electrophysiology
• heart

• Health Sciences Center, University of Oklahoma, USA

  H. Lowell Stone

• Cardiovascular Research Program, Oklahoma Medical Research Foundation, USA

  William B. Weglicki

Policies and ethics