Monoclonal Antibodies and Breast Cancer

1. Front Matter

   Pages i-xx

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2. Session I

   1. Front Matter

      Pages 1-1

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   2. Immunostaining of Estrogen Receptors in Paraffin Sections of Breast Cancers Using Anti-Estrophilin Monoclonal Antibodies

      • L. Ozzello, C. De Rosa, D. V. Habif, R. Lipton

      Pages 3-12

   3. Clinical Studies on Cell Surface Estrogen-Regulated Proteins

      • F. Hendler, W. Kingsley, D. Burns, D. House, K. Patrick, D. Yuan

      Pages 13-27

   4. MAM-6, a Carcinoma Associated Marker: Preliminary Characterisation and Detection in Sera of Breast Cancer Patients

      • J. Hilkens, V. Kroezen, F. Buijs, J. Hilgers, M. van Vliet, W. de Voogd et al.

      Pages 28-42

   5. Monoclonal Antibodies in the Study of Mammary Development and Neoplasia

      • Renato Dulbecco, W. Ross Allen, Christine White

      Pages 43-59

   6. Monoclonal Antibodies in the Study of Cell Lineage, Differentiation and Malignancy in the Human Breast

      • J. Taylor-Papadimitriou, J. Bartek, E. Durban, J. Burchell, R. C. Hallowes, E. B. Lane et al.

      Pages 60-79

   7. Studies with Monoclonal Antibodies to Breast Tumors

      • C. F. Lemaistre, D. P. Edwards, L. G. Dressler, B. Lathan, R. E. Mansel, W. L. McGuire

      Pages 80-85

3. Session II

   1. Front Matter

      Pages 87-87

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   2. Serological Dissection of Human Breast Cancer with Mouse and Human Monoclonal Antibodies

      • R. J. Cote, D. Morrissey, A. N. Houghton, T. M. Thomson, C. Cordon-Cardo, H. F. Oettgen et al.

      Pages 89-107

   3. Potential Clinical Application of a Monoclonal Antibody to a Tumor Associated Glycoprotein (TAG-72)

      • P. Horan Hand, M. O. Weeks, J. Greiner, A. Thor, D. Colcher, C. Szpak et al.

      Pages 108-118

   4. Immunocytochmistry for the Selection of Hybridomas and the Characterization of Monoclonal Antibodies: Problems, Solutions and Suggestions

      • R. Mesa-Tejada

      Pages 119-133

   5. Effector Cells in ADCC with Anti-Breast Cancer Monoclonal Antibodies

      • Z. Steplewski, M. Blaszczyk, D. Herlyn, M. Herlyn, H. Koprowski

      Pages 134-149

4. Session III

   1. Front Matter

      Pages 151-151

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   2. Use of Monoclonal Antibodies for Breast Cancer Diagnosis and Prognosis

      • M. I. Colnaghi, S. Canevari, G. Della Torre, R. Mariani-Costantini, S. Menard, S. Miotti et al.

      Pages 153-164

   3. Intracellular and Extracellular Keratins of Human Mammary Epithelial Cells

      • R. Chan, P. V. Rossitto, B. F. Edwards, R. D. Cardiff

      Pages 165-178

   4. Breast Cancer Antigens Detected with Human Monoclonal Antibodies

      • K. G. Burnett, E. Oh, J. Hayden

      Pages 179-189

   5. Monoclonal Antibodies Against Estrogen Receptor: Specificity, Sensitivity and Potential Applications

      • K. McCarty Jr., J. Snowhite, E. Cox, L. Miller, K. McCarty Sr.

      Pages 190-202

5. Session IV

   1. Front Matter

      Pages 203-203

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   2. Monoclonal Antibodies in the Characterization and Imaging of Human Breast Cancers

      • P. Furmanski

      Pages 205-217

Breast cancer, being a disease with very high prevalence in the female population, has permanently attracted the attention of biologists, biochemists, pathologists, surgeons, and oncologists. In the U.S. alone approximately 120,000 new cases are diagnosed and 37,000 deaths a year are recorded as an outcome. Early diagnosis, clear cut prognosis and the hope of new therapeutic approaches has spurred the enthusiasm of researchers, who with the advent of newer methodologies, tried to employ it in different approaches to the breast cancer patient. In spite of the efforts devoted towards the creation of new approaches, reagents and procedures taking advantage of special characteristics of the breast tissue were slow to come. In general, most diagnostic and prognostic techniques were those shared and applied to other carcinomas. In the early seventies we discovered the first sets of antigens associated with breast epithelial tissue both in the mouse and the human. The recognition of such group of molecules, present in the milk fat globule membrane, gave impetus to several studies in these areas. These mammary cell surface antigens proved useful in several diagnostic approaches such as radioimaging, histochemical and serum assay procedures. However, the apparently inherent limitations of polyclonal antibodies reduced the impact of these novel approaches.

• Antigen
• carcinoma
• cell
• imaging
• metastasis
• proteins
• tumor

• John Muir Cancer and Aging Research Insitute, Walnut Creek, USA

  Roberto L. Ceriani

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